SAITO SHINICHIRO

Research field (3)： Cell biology , Experimental pathology , Immunology

Research keywords (5)： Autoimmune Disease , plasmacytoid DC (pDC) , Dendritic Cell (DC) , Nucleic Acid-Sensing TLR , Toll-like Receptor (TLR)

Research theme for competitive and other funds (14)：

2020 - 2023 Elucidation of the onset mechanism of Type 2 Autoimmune Hepatitis and related liver diseases
2020 - 2022 Elucidation of the mechanisms using different response zones in endosome and lysosome by nucleic acid-sensing Toll-like receptors
2018 - 2020 Elucidation of response zones for nucleic acid-sensing Toll-like receptors
2016 - 2018 Elusidation of regulatory mechanism for regulatory Tcells by Arl8b
2014 - 2018 A role of Arl8b for the development of SLE

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Papers (64)：

Ryota Sato, Tatjana Reuter, Ryosuke Hiranuma, Takuma Shibata, Ryutaro Fukui, Yuji Motoi, Yusuke Murakami, Hiroki Tsukamoto, Satoshi Yamazaki, Kaiwen Liu, et al. The impact of cell maturation and tissue microenvironments on the expression of endosomal Toll-like receptors in monocytes and macrophages. International immunology. 2020. 32. 12. 785-798
Takuma Shibata, Masato Taoka, Shin-Ichiroh Saitoh, Yoshio Yamauchi, Yuji Motoi, Mayumi Komine, Etsuko Fujita, Ryota Sato, Hiroshi Sagara, Takeshi Ichinohe, et al. Nucleosides drive histiocytosis in SLC29A3 disorders by activating TLR7. 2019
Miyake K, Saitoh SI, Sato R, Shibata T, Fukui R, Murakami Y. Endolysosomal compartments as platforms for orchestrating innate immune and metabolic sensors. Journal of leukocyte biology. 2019. 106. 4. 853-862
Saitoh Shin-ichiroh, Mori Saitoh Yoshiko, Kontani Kenji, Sato Katsuaki, Miyake Kensuke. ADPリボシル化因子様8bは全身性エリテマトーデスのマウスモデル開発に必要である(ADP-ribosylation factor-like 8b is required for the development of mouse models of systemic lupus erythematosus). International Immunology. 2019. 31. 4. 225-237
Furusho Katsuhiro, Shibata Takuma, Sato Ryota, Fukui Ryutaro, Motoi Yuji, Zhang Yun, Saitoh Shin-ichiroh, Ichinohe Takeshi, Moriyama Masafumi, Nakamura Seiji, et al. シチジンデアミナーゼはシチジンやシチジンアナログによるToll様受容体8活性化を可能にする(Cytidine deaminase enables Toll-like receptor 8 activation by cytidine or its analogs). International Immunology. 2019. 31. 3. 167-173

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MISC (116)：

Furusho Katsuhiro, Shibata Takuma, Sato Ryota, Fukui Ryutaro, Motoi Yuji, Saitoh Shin-ichiroh, Miyake Kensuke. 自然免疫自然認識とシグナル伝達 Cytidineはcytidineまたはその類似物質によりトル様受容体8の活性化を可能にする(Innate immunity(1)- innate recognition and signalings Cytidine deaminase enables Toll-like receptor 8 activation by cytidine or its analogs). 日本免疫学会総会・学術集会記録. 2019. 48. Proceedings. 1-O/P
Saitoh Shin-ichiroh, Miyake Kensuke. 臓器特異的自己免疫疾患 Rab7a欠損樹状細胞による交差抗原提示の増加は2型自己免疫性肝炎を引き起こす(Organ-specific autoimmune diseases Increased cross-presentation by Rab7a deficient dendritic cells causes type 2 autoimmune hepatitis). 日本免疫学会総会・学術集会記録. 2019. 48. Proceedings. 3-P
FURUSHO Katsuhiro, SHIBATA Takuma, SATO Ryota, FUKUI Ryutaro, MOTOI Yuji, SAITOH Shin-ichiroh, MIYAKE Kensuke. Cytidine deaminase enables Toll-like receptor 8 activation by cytidine or its analogs. 日本免疫学会総会・学術集会記録(CD-ROM). 2019. 48
齋藤伸一郎. 形質細胞様樹状細胞のTLR7による1型インターフェロン産生誘導機構の解明. 感染・炎症・免疫. 2019. 49. 1. 31-41
齋藤伸一郎. ウイルス感染防御と免疫反応制御のためのエンドソーム・ライソソームゾーン. 日本生化学会大会(Web). 2019. 92nd. [1S16a-05]

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Books (5)：

Toll-Like Receptors and Their Regulatory Mechanisms.
2011
TLR4の病原体認識におけるアクセサリー分子の役割
秀潤社 2006
LPSの認識とTLR4/MD-2の多量体形成 (自然免疫)
中山書店 2005
エンドトキシン(LPS)の認識機構とTLR4の活性化機構
羊土社 2004
自然免疫とToll-like receptor(TLR)のシグナル伝達
羊土社 2004

Lectures and oral presentations (20)：

ADP-ribosylation factor-like 8b is required for the pathogenesis of mouse models of Systemic Lupus Erythematosus
(2017)
Arl8bは全身性エリテマトーデスモデルマウスBXSB.Yaaの病気の発症に関わっている.
(第23回日本エンドトキシン・自然免疫研究会 2017)
Metabolic permission for IFNa induction is connected by Toll-like Receptor 7 trafficking
(第45回日本免疫学会学術集会 2016)
Toll-like receptor 7の移動は代謝センサーmTorC1による1型インターフェロン産生の制御と結びついている.
(第22回日本エンドトキシン・自然免疫研究会 2016)
The Arf-like GTPase Arl8b drives TLR7 into type I interferon-mediated inflammation
(2013)

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Professional career (1)：

医学博士 (大阪大学)

Committee career (1)：

2018/12 - 現在日本エンドトキシン・自然免疫研究会理事

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