SAITO SHINICHIRO

Research field (3)： Cell biology , Experimental pathology , Immunology

Research keywords (5)： Autoimmune Disease , plasmacytoid DC (pDC) , Dendritic Cell (DC) , Nucleic Acid-Sensing TLR , Toll-like Receptor (TLR)

Research theme for competitive and other funds (15)：

2024 - 2027 自己免疫性溶血性貧血の発生機序及び自己抗体産生メカニズムの解明
2020 - 2023 Elucidation of the onset mechanism of Type 2 Autoimmune Hepatitis and related liver diseases
2020 - 2022 Elucidation of the mechanisms using different response zones in endosome and lysosome by nucleic acid-sensing Toll-like receptors
2018 - 2020 Elucidation of response zones for nucleic acid-sensing Toll-like receptors
2016 - 2018 Elusidation of regulatory mechanism for regulatory Tcells by Arl8b

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Papers (70)：

Shiori Kaji, Izumi Sasaki, Satoko Kunimoto, Naoko Wakaki-Nishiyama, Emi Tosuji, Ayano Kurara, Takashi Kato, Chisako Mutsukawa, Daisuke Okuzaki, Chizuyo Okamoto, et al. Immunological characterization of peritoneal exudate cells in liver cirrhosis patients. 2025
Daisuke Aki, Taeko Hayakawa, Tanakorn Srirat, Shigeyuki Shichino, Minako Ito, Shin-Ichiroh Saitoh, Setsuko Mise-Omata, Akihiko Yoshimura. The Nr4a family regulates intrahepatic Treg proliferation and liver fibrosis in MASLD models. The Journal of clinical investigation. 2024. 134. 23
Izumi Sasaki, Yuri Fukuda-Ohta, Chihiro Nakai, Naoko Wakaki-Nishiyama, Chizuyo Okamoto, Daisuke Okuzaki, Shuhei Morita, Shiori Kaji, Yuki Furuta, Hiroaki Hemmi, et al. A stress sensor, IRE1α, is required for bacterial-exotoxin-induced interleukin-1β production in tissue-resident macrophages. Cell Reports. 2024. 43. 4. 113981-113981
Takuma Shibata, Ryota Sato, Masato Taoka, Shin-Ichiroh Saitoh, Mayumi Komine, Kiyoshi Yamaguchi, Susumu Goyama, Yuji Motoi, Jiro Kitaura, Kumi Izawa, et al. TLR7/8 stress response drives histiocytosis in SLC29A3 disorders. The Journal of experimental medicine. 2023. 220. 9
Sajid Iftekhar Chowdhury, Masanori Inui, Tatsuya Yamazaki, Susumu Tomono, Hidekazu Takagi, Mrityunjoy Biswas, Shin-Ichiroh Saitoh, Kensuke Miyake, Sachiko Akashi-Takamura. The anti-TLR4 monoclonal antibody Sa15-21 enhances inflammatory cytokine production in LPS-stimulated macrophages. FEBS letters. 2023. 597. 9. 1246-1260

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MISC (127)：

齋藤伸一郎. Roles of small G protein Arl8b in the pathogenesis of systemic lupus erythematosus mediated by Toll-like receptor (TLR)7. エンドトキシン・自然免疫研究(Web). 2024. 25
齋藤伸一郎. TLR7, Unc93b1, and senescence-associated T cells mediate the pathogenesis of systemic lupus erythematosus. 和歌山医学. 2024. 75. 4
齋藤伸一郎, 齋藤良子. 全身性エリテマトーデスモデルマウスMRL/lprの発症におけるArl8bの役割. 日本エンドトキシン・自然免疫研究会プログラム・抄録集. 2023. 28th
Saitoh Shin-ichiroh, Harada Kenichi, Mori-Saitoh Yoshiko, Sun-Wada Ge-Hong, Denda Tamami, Ota Yasunori, Sagara Hiroshi, Watanabe Yuji, Wada Yoh, Miyake Kensuke. 樹状細胞とマクロファージ-1 免疫制御とdisease perspectives 樹状細胞のエンドソーム異常が自己免疫性肝疾患を引き起こす(Dendritic cells and macrophages-1:Immune regulation and disease perspectives Endosomal abnormalities in dendritic cells cause autoimmune liver diseases). 日本免疫学会総会・学術集会記録. 2022. 51. Proceedings. WS04-O/P
Shibata Takuma, Sato Ryota, Saitoh Shin-ichiroh, Miyake Kensuke. 自然免疫(2) Innate recognitionおよびシグナル伝達 SLC29A3障害においてTLR7ストレス応答が組織球増殖症を促進する(Innate immunity(2) Innate recognition and signaling TLR7 stress response drives histiocytosis in SLC29A3 disorders). 日本免疫学会総会・学術集会記録. 2022. 51. Proceedings. WS30-P

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Books (5)：

Toll-Like Receptors and Their Regulatory Mechanisms.
2011
TLR4の病原体認識におけるアクセサリー分子の役割
秀潤社 2006
LPSの認識とTLR4/MD-2の多量体形成 (自然免疫)
中山書店 2005
エンドトキシン(LPS)の認識機構とTLR4の活性化機構
羊土社 2004
自然免疫とToll-like receptor(TLR)のシグナル伝達
羊土社 2004

Lectures and oral presentations (20)：

ADP-ribosylation factor-like 8b is required for the pathogenesis of mouse models of Systemic Lupus Erythematosus
(2017)
Arl8bは全身性エリテマトーデスモデルマウスBXSB.Yaaの病気の発症に関わっている.
(第23回日本エンドトキシン・自然免疫研究会 2017)
Metabolic permission for IFNa induction is connected by Toll-like Receptor 7 trafficking
(第45回日本免疫学会学術集会 2016)
Toll-like receptor 7の移動は代謝センサーmTorC1による1型インターフェロン産生の制御と結びついている.
(第22回日本エンドトキシン・自然免疫研究会 2016)
The Arf-like GTPase Arl8b drives TLR7 into type I interferon-mediated inflammation
(2013)

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Professional career (1)：

医学博士 (大阪大学)

Work history (1)：

2023/04 - 現在 Institute of Advanced Medicine, Wakayama Medical University Department of Intractable Disorders Professor

Committee career (1)：

2018/12 - 現在日本エンドトキシン・自然免疫研究会理事

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