Shirasaki Takayoshi

シラサキタカヨシ | Shirasaki Takayoshi

Affiliation and department：

Research field (1)： Virology

Research theme for competitive and other funds (4)：

2016 - 2019 Molecular mechanisms and biological, clinical significance of IFNL4
2016 - 2017 Elucidation of the mechanisms of HBV infection using single cell transcriptome analysis
2014 - 2016 Establishment new HCC derived cell lines that support efficient hepatitis virus replication.
2013 - 2016 Elucidation of the mechanisms of non-response to antiviral treatment in chronic hepatitis C

Papers (43)：

Junyan Lyu, Hikari Okada, Hajime Sunagozaka, Kazunori Kawaguchi, Tetsuro Shimakami, Kouki Nio, Kazuhisa Murai, Takayoshi Shirasaki, Mika Yoshida, Kuniaki Arai, et al. Potential utility of l-carnitine for preventing liver tumors derived from metabolic dysfunction-associated steatohepatitis. Hepatology communications. 2024. 8. 5
Ryogo Shimizu, Kazuhisa Murai, Kensuke Tanaka, Yuga Sato, Naho Takeda, Saki Nakasyo, Takayoshi Shirasaki, Kazunori Kawaguchi, Tetsuro Shimakami, Kouki Nio, et al. Nucleos(t)ide analogs for hepatitis B virus infection differentially regulate the growth factor signaling in hepatocytes. Hepatology Communications. 2024. 8. 1
Ryu Imamura, Hiroki Sato, Dominic Chih-Cheng Voon, Takayoshi Shirasaki, Masao Honda, Makoto Kurachi, Katsuya Sakai, Kunio Matsumoto. Met receptor is essential for MAVS-mediated antiviral innate immunity in epithelial cells independent of its kinase activity. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 40. e2307318120
Takayoshi Shirasaki, Kazuhisa Murai, Atsuya Ishida, Kazuyuki Kuroki, Kazunori Kawaguchi, Ying Wang, Souma Yamanaka, Rio Yasukawa, Narumi Kawasaki, Ying-Yi Li, et al. Functional involvement of endothelial lipase in hepatitis B virus infection. Hepatology communications. 2023. 7. 9
Ying-Yi Li, Kazuyuki Kuroki, Tetsuro Shimakami, Kazuhisa Murai, Kazunori Kawaguchi, Takayoshi Shirasaki, Kouki Nio, Saiho Sugimoto, Tomoki Nishikawa, Hikari Okada, et al. Hepatitis B virus utilizes a retrograde trafficking route via the trans-Golgi network to avoid lysosomal degradation. Cellular and molecular gastroenterology and hepatology. 2022. 15. 3. 533-558

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MISC (68)：

Kazuhisa Murai, Masao Honda, Takayoshi Shirasaki, Shuichi Kaneko. IDENTIFICATION OF A HOST FACTOR FOR THE IMPROVEMENT OF IMMUNE CHECKPOINT BLOCKADE THERAPY FOR HEPATOCELLULAR CARCINOMA. HEPATOLOGY. 2019. 70. 808A-809A
Souma Yamanaka, Masao Honda, Takayoshi Shirasaki, Tetsuro Shimakami, Ryosuke Shimizu, Kazuhisa Murai, Miwako Narita, Hirofumi Misu, Toshinari Takamura, Taro Yamashita, et al. A LIVER-DERIVED SECRETORY PROTEIN, LECT2, RESTORES THE IMPAIRED PLASMACYTOIDDENDRITIC CELLS FUNCTION BY HBV AND PROTECTS HEPATOCYTES AGAINST HBV INFECTION. HEPATOLOGY. 2019. 70. 616A-617A
Takayoshi Shirasaki, Masao Honda, Kazuhisa Murai, Tetsuro Shimakami, Hirofumi Misu, Toshinari Takamura, Shuichi Kaneko. A Liver-Derived Secretory Protein, LECT2, Enhances the Innate Immune Response and Suppresses RIG-I Mediated Virus Infection. HEPATOLOGY. 2018. 68. 588A-589A
Kazuhisa Murai, Masao Honda, Tetsuro Shimakami, Takayoshi Shirasaki, Hirofumi Misu, Toshinari Takamura, Shuichi Kaneko. mRNA for selenoprotein P, a hepatokine, binds RIG-I protein and inhibits the RIG-I-mediated type I interferon response. CYTOKINE. 2017. 100. 76-76
Kazuhisa Murai, Masao Honda, Tetsuro Shimakami, Takayoshi Shirasaki, Shiho Tanaka, Shuichi Kaneko. IFN-lambda 3 induces dendritic cell maturation independently of type I IFN. CYTOKINE. 2017. 100. 117-117

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Patents (3)：

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