Research keywords (3)：
Multidrug resistant bacteria
, effector
, type III secretion system
Research theme for competitive and other funds (20)：
2022 - 2024 Development of a screening system that inhibits bacterial regulatory factor A, which contributes to multi-drug resistance
2019 - 2022 Functional analysis of Bcr4 involved in activation of the Bordetella type III secretion system
2019 - 2022 新たな百日咳ワクチンの開発に向けて-外膜ベシクルと宿主細胞の相互作用
2020 - 2022 Verification of the effect of gene A on drug-resistant bacteria
2016 - 2019 Functional analysis of the Bordetella secreted regulator BspR
2014 - 2017 Analyses of the functions of Bordetella BopC that induce actin-dependent necrotic cell death.
2013 - 2015 Dual effector BspR that functions in Bordetella and host cells
2012 - 2015 Directing of decdritic cells by Bordetella type III effectors
2009 - 2011 Comprehensive analysis of Bordetella type III effectors
2009 - 2010 ボルデテラ属細菌の定着における宿主応答抑制機構の解析
2007 - 2008 ボルデテラ属細菌のエフェクターの機能解析
2006 - 2008 Comprehensive analyses of the type III effectors in pathogenic Escherichia coli
2004 - 2005 Functional analyses of the type III effectors in pathogenic E.coli
2003 - 2005 Ultrastructural Analysis of Mechanism of Protein-Domain-Assembly on Cell Membrane of Specific Lipid-Binding Toxin.
2002 - 2002 病原細菌のタイプIII分泌装置の機能とその超微形態学的解析
2001 - 2001 病原細菌のタイプIII分泌装置の超微形態学的解析
1999 - 2000 病原性大腸菌の病原性発揮に関与する宿主細胞因子の解析
1994 - 1994 細菌感染時におけるマクロファージ遺伝子の発現機構
1993 - 1994 Cellular Localization, qurification, and function of plasmud-determinedrirulence proteins of Salmonella
1992 - 1992 サルモネラのプラスミド性病原遺伝子の転写制御
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Papers (58)：
Yoshihiro Watanabe, Takeshi Haneda, Aoi Kimishima, Asaomi Kuwae, Takuya Suga, Takahiro Suzuki, Yoshiharu Iwabuchi, Masako Honsho, Sota Honma, Masato Iwatsuki, et al. PurA is the main target of aurodox, a type III secretion system inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 2024. 121. 17. e2322363121
Yuta Kikuchi, Mariko Yoshida, Asaomi Kuwae, Yukihiro Asami, Yuki Inahashi, Akio Abe. Correlation between the spread of IMP-producing bacteria and the promoter strength of blaIMP genes. The Journal of antibiotics. 2024
Masataka Goto, Akio Abe, Tomoko Hanawa, Masato Suzuki, Asaomi Kuwae. Bcr4 Is a Chaperone for the Inner Rod Protein in the Bordetella Type III Secretion System. Microbiology Spectrum. 2022. 10. 5
Yuta Kikuchi, Hidehito Matsui, Yukihiro Asami, Asaomi Kuwae, Yuki Inahashi, Hideaki Hanaki, Akio Abe. Landscape of blaNDM genes in Enterobacteriaceae. The Journal of Antibiotics. 2022. 75. 10. 559-566
Aoi Kimishima, Daichi Hagimoto, Masako Honsho, Yoshihiro Watanabe, Masato Iwatsuki, Hayama Tsutsumi, Yuki Inahashi, Kamrun Naher, Kazunari Sakai, Asaomi Kuwae, et al. Insights into the structure-activity relationship of a type III secretion system inhibitor, aurodox. Bioorganic & medicinal chemistry letters. 2022. 69. 128779-128779
