Shigehiro Yagishita

ヤギシタシゲヒロ | Shigehiro Yagishita

Affiliation and department：
Job title： Laboratory Head
Other affiliations (1)：

National Cancer Center,Research Institute Department of Pharmacology and Therapeutics Laboratory Head

Research field (3)： Tumor diagnostics and therapeutics , Respiratory medicine , Clinical pharmacy

Research keywords (5)： TR研究 , 非臨床試験 , pharmacokinetics/pharmacodynamics , Patient-derived xenograft model , Lung cancer

Research theme for competitive and other funds (6)：

2022 - 2025 糖鎖修飾に基づく抗体医薬の薬物動態研究
2021 - 2025 Development of a novel cell differentiation cancer therapy
2021 - 2025 中皮腫における細胞系譜構築による新規治療法の探究と臨床応用
2020 - 2023 ユビキチン化を標的とした細胞死と細胞老化誘導による小細胞肺がん新規治療法の探索
2020 - 2023 PDXモデルを用いた非臨床試験の実施に係る標準化に関する研究

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Papers (113)：

Shigehiro Yagishita, Yuta Yamanaka, Takayasu Kurata, Kageaki Watanabe, Yukio Hosomi, Hidehito Horinouchi, Yuichiro Ohe, Yoshiro Nakahara, Katsuhiko Naoki, Tetsuhiko Asao, et al. Multicenter Pharmacokinetic and Pharmacodynamic Study of Pembrolizumab for Non-small-Cell Lung Cancer in Patients Aged 75 Years and Older. Clinical Pharmacology & Therapeutics. 2024
Shinji Kohsaka, Shigehiro Yagishita, Yukina Shirai, Yusuke Matsuno, Toshihide Ueno, Shinya Kojima, Hiroshi Ikeuchi, Masachika Ikegami, Rina Kitada, Ken-ichi Yoshioka, et al. A molecular glue RBM39-degrader induces synthetic lethality in cancer cells with homologous recombination repair deficiency. npj Precision Oncology. 2024. 8. 1
Masahiro Torasawa, Tatsuya Yoshida, Kouya Shiraishi, Naoko Goto, Toshihide Ueno, Hitoshi Ichikawa, Shigehiro Yagishita, Shinji Kohsaka, Yasushi Goto, Yasushi Yatabe, et al. Rapid Response to Lenvatinib and Disease Flare After Discontinuation in a Patient With Thymic Carcinoma Harboring KIT Exon 11 Mutation: A Case Report. JTO clinical and research reports. 2024. 5. 4. 100657-100657
Yuki Katsuya, Tatsuya Yoshida, Atsuo Takashima, Kan Yonemori, Akihiro Ohba, Shu Yazaki, Shigehiro Yagishita, Hiroko Nakahama, Osamu Kobayashi, Masatoshi Yanagida, et al. Immunogenicity after vaccination of COVID-19 vaccines in patients with cancer: a prospective, single center, observational study. International journal of clinical oncology. 2024. 29. 4. 386-397
Bunpei Miyazaki, Toshihide Ueno, Masanaka Sugiyama, Shinya Kojima, Ayumu Arakawa, Kayoko Tao, Kazuki Tanimura, Kouya Shiraishi, Shigehiro Yagishita, Shinji Kohsaka, et al. Promoter swapping of truncated PDGFRB drives Ph-like acute lymphoblastic leukemia. npj Precision Oncology. 2023. 7. 1

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MISC (28)：

津端由佳里, 山中雄太, 倉田宝保, 渡邊景明, 細見幸生, 堀之内秀仁, 大江裕一郎, 中原善朗, 朝尾哲彦, 佐伯祥, et al. 75歳以上の非小細胞肺癌患者におけるペムブロリズマブの薬物動態と高齢者機能評価に関する多施設共同研究. 日本肺癌学会学術集会号. 2023. 64th (CD-ROM)
虎澤匡洋, 藤田雄, 柳下薫寛, 堀之内秀仁, 大熊加惠, 松元祐司, 新野祐樹, 大熊裕介, 吉田達哉, 後藤悌, et al. Proteomic analysis of serum exosomes to identify risk factors for lung injury during durvalumab in locally advanced non-small cell lung cancer. 日本呼吸器学会誌(Web). 2023. 12
渡邊景明, 細見幸生, 山中雄太, 倉田宝保, 堀之内秀仁, 大江裕一郎, 朝尾哲彦, 中原善朗, 佐伯祥, 津端由佳里, et al. Multicenter Pharmacokinetic Study of Pembrolizumab for Non-Small Cell Lung Cancer in Older Adults Aged Over 75 Years. 日本呼吸器学会誌(Web). 2023. 12
伊藤宗洋, 吉田達哉, 柳下薫寛, 荒川さやか, 白澤昌之, 松元祐司, 新野祐樹, 大熊裕介, 後藤悌, 堀之内秀仁, et al. EGFR遺伝子変異陽性NSCLCにおけるコバスリキッドバイオプシー陽性率と増悪形式の検討. 日本肺癌学会総会号. 2020. 61st
坂本康成, 肱岡範, 前原耕介, 谷本泉, 丸木雄太, 永塩美邦, 大場彬博, 近藤俊輔, 森実千種, 柳下薫寛, et al. 膵癌EUS-FNA検体からのPatient-derived xenograft(PDX)モデル作製の可能性について. 膵臓. 2019. 34. 3. A248-A248

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Education (2)：

2012 - 2016 順天堂大学大学院医学研究科
2001 - 2007 Hokkaido University School of Medicine

Professional career (1)：

PhD (Juntendo University)

Work history (12)：

2024/04 - 現在 National Cancer Center Research Institute Department of Pharmacology and Therapeutics Laboratory Head
2024/04 - 現在 National Cancer Center Research Institute Division of Molecular Pharmacology Laboratory Head
2023/02 - 2024/03 国立研究開発法人国立がん研究センター研究所分子薬理研究分野主任研究員
2018/01 - 2023/01 National Cancer Center
2016/04 - 2017/12 順天堂大学医学部附属浦安病院呼吸器内科助教

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Association Membership(s) (2)：

日本呼吸器学会(呼吸器専門医) , 日本内科学会(認定内科医)

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