Junko Oshima

オオシマジュンコ | Junko Oshima

Affiliation and department：
Job title： Research Professor Emeritus
Other affiliations (1)：

Research field (1)： Internal medicine - General

Research keywords (5)： Progeria , Internal medicine , Aging , Genome , Genetics

Research theme for competitive and other funds (7)：

2019 - 2025 Genetic and Non-Genetic Modulators of Morbidity/Disability Compression in aLarge Population-Based Study of Cognitive and Physical Impairment with Emphasis on Alzheimer's Disease and Related Dementias
2021 - 2024 脂肪や血管組織老化に伴う機能変容における老化関連長鎖非コードRNAの基盤的研究
2016 - 2022 International Registry of Werner Syndrome
2017 - 2020 早老症の遺伝原因同定と、正常加齢への寄与の検索
2016 - 2018 Genetic Modulations of Morbidity Compression:A Population-Based Study

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Papers (131)：

Danny E Miller, Lin Lee, Miranda Galey, Renuka Kandhaya-Pillai, Marc Tischkowitz, Deepak Amalnath, Avadh Vithlani, Koutaro Yokote, Hisaya Kato, Yoshiro Maezawa, et al. Targeted long-read sequencing identifies missing pathogenic variants in unsolved Werner syndrome cases. Journal of medical genetics. 2022. 59. 11. 1087-94
Renuka Kandhaya-Pillai, Deyin Hou, Jiaming Zhang, Xiaomeng Yang, Goli Compoginis, Takayasu Mori, Tamara Tchkonia, George M Martin, Fuki M Hisama, James L Kirkland, et al. SMAD4 mutations and cross-talk between TGF-β/IFNγ signaling accelerate rates of DNA damage and cellular senescence, resulting in a segmental progeroid syndrome-the Myhre syndrome. GeroScience. 2021. 43. 3. 1481-1496
Junko Oshima, George M Martin, Fuki M Hisama. Werner Syndrome. 2021
George M Martin, Fuki M Hisama, Junko Oshima. Review of How Genetic Research on Segmental Progeroid Syndromes Has Documented Genomic Instability as a Hallmark of Aging But Let Us Now Pursue Antigeroid Syndromes!. The journals of gerontology. Series A, Biological sciences and medical sciences. 2021. 76. 2. 253-259
Iram Hussain, Ruilin Raelene Jin, Howard B A Baum, Jerry R Greenfield, Sophie Devery, Chao Xing, Robert A Hegele, Barbara G Carranza-Leon, Macrae F Linton, Frank Vuitch, et al. Multisystem Progeroid Syndrome With Lipodystrophy, Cardiomyopathy, and Nephropathy Due to an LMNA p.R349W Variant. Journal of the Endocrine Society. 2020. 4. 10. bvaa104

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MISC (7)：

B. Saha, G. Zitnik, S. Johnson, Q. Nguyen, G. M. Martin, J. Oshima. TRF2 Degradation and DNA Damage Accumulation in LMNA Mutant Atypical Werner Syndrome Fibroblasts. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL. 2012. 48. 48-48
J Oshima, A Garg, GM Martin, BK Kennedy. LMNA mutations in atypical Werner's syndrome - Reply. LANCET. 2003. 362. 9395. 1586-1586
MJ Moser, J Oshima, RJ Monnat. WRN mutations in Werner syndrome (vol 13, pg 271, 1998). HUMAN MUTATION. 1999. 14. 1. 84-85
L Ye, T Miki, J Nakura, J Oshima, A Morishima, H Rakugi, H Ikegami, J Higaki, D Edland, M Martin, et al. A polymorphic variant of Werner syndrome gene (WRN) association with myocardial infarction (MI) in Japanese population. AMERICAN JOURNAL OF HUMAN GENETICS. 1997. 61. 4. A301-A301
L Ye, T Miki, J Nakura, J Oshima, K Kamino, H Rakugi, H Ikegami, J Higaki, SD Edland, GM Martin, et al. Rapid publication: Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population (vol 68, pg 494, 1997). AMERICAN JOURNAL OF MEDICAL GENETICS. 1997. 70. 1. 103-103

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Lectures and oral presentations (18)：

The Spectrum of WRN Mutations in Werner Syndrome Patients
(日本老年医学会 2021)
Genetics of Aging: Molecular Mechanisms of Progeroid Syndromes”
(Seminars in Medical Sciences Series 2019)
Genetics of Aging: Molecular Mechanisms of Progeroid Syndromes
(Leading Seminar, Chiba University 2019)
International Registry of Werner Syndrome: Search for progeroid syndrome mutations and mechanisms
(Cold Spring Harbor Laboratory Meeting “Mechanism of Aging”. 2018)
International Registry of Werner Syndrome: Search for progeroid syndrome mutations and mechanisms
(International Meeting on RECQ Helicases and Related Diseases 2018, 2018)

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Education (3)：

1986 - 1992 Boston University School of Medicine Doctoral course of Garaduate School Department of Biochemistry
1978 - 1984 University of Tsukuba School School of Medicine
1975 - 1978 Nagano Prefectural Nagano Senior Hihg School

Professional career (2)：

Work history (13)：

2016/08/01 - University of Washington School of Medicine Pathology Research Professor Emeritus
2015/12/01 - Chiba University Graduate School of Medicine Innovation Medicine Professor
2013/07/01 - 2015/07/31 University of Washington School of Medicine Pathology Research Professor
2001/06/01 - 2013/06/30 University of Washington School of Medicine Pathology Research Associate Professor
1996/03/01 - 2001/05/31 University of Washington School of Medicine Pathology Research Assistant Professor

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Committee career (19)：

2006/01 - 現在 American Federation for Aging Research, New York, NY National Scientific Advisory
2021/04 - NIH study section, NIH NIA ZAG1 LRP
2020/04 - NIH study section, NIH NIA ZAG1 LRP
2019/05 - NIH study section NIH NIA ZAG1 ZIJ-4 (M5) LRP
2018/10 - NIH study section NIH NIA ZAG1 ZIJ-G (J4) PPG

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Awards (1)：

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