2013 - 2016 Molecular mechanisms involved in zinc-deficiency mediated epigenetic regulation of gene expression
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Papers (42)：
Takumi Sato, Ryota Shizu, Ryonosuke Baba, Akira Ooka, Takuomi Hosaka, Yuichiro Kanno, Kouichi Yoshinari. Pregnane X receptor inhibits the transdifferentiation of hepatic stellate cells by downregulating periostin expression. The Biochemical journal. 2024
Shunnosuke Kaito, Jun-ichi Takeshita, Misaki Iwata, Takamitsu Sasaki, Takuomi Hosaka, Ryota Shizu, Kouichi Yoshinari. Utility of human cytochrome P450 inhibition data in the assessment of drug-induced liver injury. Xenobiotica. 2024
Ryota Shizu, Natsuki Makida, Keiichiro Sobe, Mai Ishimura, Aki Takeshita, Takuomi Hosaka, Yuichiro Kanno, Takamitsu Sasaki, Kouichi Yoshinari. Interaction with YAP underlies the species differences between humans and rodents in CAR-dependent hepatocyte proliferation. Toxicological sciences : an official journal of the Society of Toxicology. 2023
Takumi Sato, Ryota Shizu, Yoshie Miura, Takuomi Hosaka, Yuichiro Kanno, Takamitsu Sasaki, Kouichi Yoshinari. Development of a strategy to identify and evaluate direct and indirect activators of constitutive androstane receptor in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022. 170. 113510-113510
Yuichiro Kanno, Nao Saito, Ryota Saito, Tomohiro Kosuge, Ryota Shizu, Tomofumi Yatsu, Takuomi Hosaka, Kiyomitsu Nemoto, Keisuke Kato, Kouichi Yoshinari. Differential DNA-binding and cofactor recruitment are possible determinants of the synthetic steroid YK11-dependent gene expression by androgen receptor in breast cancer MDA-MB 453 cells. Experimental cell research. 2022. 419. 2. 113333-113333
佐藤拓海, 志津怜太, 保坂卓臣, 佐々木崇光, 菅野裕一朗, 吉成浩一. Mechanism of the nuclear receptor PXR-mediated suppression of transdifferentiation of hepatic stellate cells. 日本薬学会年会要旨集(Web). 2023. 143rd
志津怜太, 佐藤拓海, 三浦佳恵, 保坂卓臣, 菅野裕一朗, 佐々木崇光, 吉成浩一. Screening of nuclear receptor CAR and PPARα activation potential of chemicals which cause liver cancer in rat carcinogenicity test. 衛生薬学・環境トキシコロジー講演要旨集. 2022. 2022
佐藤拓海, 志津怜太, 志津怜太, 馬場遼之介, 石村麻衣, 保坂卓臣, 保坂卓臣, 佐々木崇光, 菅野裕一朗, 菅野裕一朗, et al. Mechanism of the nuclear receptor PXR-mediated suppression of epithelial-mesenchymal transition of liver cancer cells. 日本薬学会年会要旨集(Web). 2022. 142nd
馬場遼之介, 志津怜太, 佐藤拓海, 保坂卓臣, 菅野裕一朗, 吉成浩一. Evaluation of the influence of PXR activation on epithelial-mesenchymal transition of liver cancer cells using reporter assay with the VIMENTIN promoter. 衛生薬学・環境トキシコロジー講演要旨集. 2022. 2022
佐藤拓海, 志津怜太, 志津怜太, 馬場遼之介, 石村麻衣, 保坂卓臣, 保坂卓臣, 佐々木崇光, 菅野裕一朗, 菅野裕一朗, et al. A mechanism for the nuclear receptor PXR-mediated suppression of liver cancer progression. Journal of Toxicological Sciences. 2022. 47. Supplement (CD-ROM)
