Hara Hideaki

ハラヒデアキ | Hara Hideaki

Affiliation and department：
Job title： President
Homepage URL (1)： http://sv1.gifu-pu.ac.jp/lab/seitaikinou/

Research field (3)： Pharmaceuticals - health and biochemistry , Ophthalmology , Neuroscience - general

Research keywords (6)：医薬品開発 , 眼科 , 精神疾患 , 神経科学 , 神経再生 , 脳卒中(脳虚血、脳出血)

Research theme for competitive and other funds (27)：

2020 - 2023 犬の変性性脊髄症を起こす変異SOD1蛋白質の立体構造解析と治療基盤の構築
2020 - 2023 緑内障視路変性における血液中エクソソーム解析による病態関連バイオマーカーの探索
2019 - 2022 Development of molecular targeted drug using high-resolution epitope mapping: a novel therapeutic strategy for intraocular fibrotic scarring
2019 - 2022 Investigation of novel drugs for inducing retinal regeneration
2018 - 2021 ルテイン投与による還元型チオール増加を介した抗酸化能力の増強

2017 - 2020 Development of therapeutic drugs targeting VGF-modifying peptides in retinal diseases

2016 - 2019 The role of progranulin in retinal regeneration

2014 - 2018 Structural and morphorogical changes after glaucoma surgery

2015 - 2017 Nrf2 activator attenuates brain ischemia-reperfusion injury.

2014 - 2017 A study for protective mechanisms of VGF, a neurosecretory peptide, in glaucomatous optic nerve degeneration

2013 - 2016 Studies on topical application of BONAC nucleic with liposomal formulation for advanced clinical treatment

2013 - 2016 Identification of glycoprotein nonmetastatic melanoma protein B (GPNMB) receptor and effect of GPNMB in higher brain function

2013 - 2016 Involvement of aquaporin in the formation of optic nerve edema and protective effects of blocking the AQP channels.

2011 - 2013 A study for protective mechanisms of VGF, a neurosecretory peptide, in retinal injury

2010 - 2012 緑内障性神経障害:網膜から高次脳神経及びグリア細胞に及ぶ系統的器質障害機構の解明

2010 - 2012 Involvement of activated P2X7 receptor in disorder of retinal ganglion cells in animal models of glaucoma

2010 - 2012 Determination of neuro-protective effects of statin on the retinal injuries through activated glial cells.

2009 - 2011 Novel Dosage form design for ocular and pulmonary drug delivery based on analysis of behavior of nano-particle as drug carrier

2009 - 2011 Molecular design and chemical genetic approach of bio-probe for anti-angiogenic therapy

2009 - 2011 Morphological and functional changes in visual cortex after retinal damage and its pharmacological approach

2008 - 2010 A study of molecular mechanisms of endoplasmic reticulum stress in retinal ganglion cell death

2007 - 2009 Research on the roles of metallothioneins in aging, brain ischemia and metabolic syndrome and drug discover

2007 - 2008 Changes in visual fields and retinal function in high intraocular pressure model of monkeys

2007 - 2008 SIRT1による神経細胞保護の分子機構の解明

2006 - 2008 Damage of retinal ganglion cells : Mechanism of the cell death in the local and central nervous system and protection and regeneration of the neural cells.

2006 - 2007 緑内障及び糖尻病網膜症の病態におけるアルツハイマー病の関連性について

2005 - 2006 Functional changes mediated by high-intraocular pressure-induced optic nerve damage in lateral geniculate body and visual cortex of monkeys.

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Papers (593)：

Aomi Muramatsu, Shinsuke Nakamura, Tasuku Hirayama, Hideko Nagasawa, Akihiro Ohira, Takashi Kitaoka, Hideaki Hara, Masamitsu Shimazawa. Both hemoglobin and hemin cause damage to retinal pigment epithelium through the iron ion accumulation. Journal of Pharmacological Sciences. 2024. 155. 2. 44-51
Aomi Muramatsu, Shinsuke Nakamura, Tasuku Hirayama, Hideko Nagasawa, Akihiro Ohira, Takashi Kitaoka, Hideaki Hara, Masamitsu Shimazawa. Both hemoglobin and hemin cause damage to retinal pigment epithelium through the iron ion accumulation. Journal of Pharmacological Sciences. 2024. 155. 2. 44-51
Tomoaki Araki, Masamitsu Shimazawa, Shinsuke Nakamura, Wataru Otsu, Yosuke Numata, Megumi Sakata, Koji Kabayama, Hideshi Tsusaki, Hideaki Hara. Investigation into the usefulness of cynomolgus monkeys with spontaneously elevated intraocular pressure as a model for glaucoma treatment research. Journal of Pharmacological Sciences. 2024. 154. 2. 52-60
Kanta Yamazaki, Kodai Ishida, Wataru Otsu, Aomi Muramatsu, Shinsuke Nakamura, Wakana Yamada, Hideshi Tsusaki, Hiroshi Shimoda, Hideaki Hara, Masamitsu Shimazawa. Delphinidins from Maqui Berry (Aristotelia chilensis) ameliorate the subcellular organelle damage induced by blue light exposure in murine photoreceptor-derived cells. BMC Complementary Medicine and Therapies. 2024. 24. 1
Honoka Fujimori, Takuya Ohba, Shinsuke Nakamura, Masamitsu Shimazawa, Hideaki Hara. The Involvement of Progranulin for α-Synuclein Reduction through Autolysosome Formation. Biological and Pharmaceutical Bulletin. 2023. 46. 8. 1032-1040

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MISC (257)：

岡なつみ, 松原博文, 松原博文, HONG Doan Van Thi, 今井貴彦, 香月純, 藤井翔太, 中村信介, 櫻井和朗, 嶋澤雅光, et al. マウス脳梗塞モデルに対するナノ粒子化α-マンゴスチンの神経保護作用. 脳循環代謝(Web). 2021. 33. 1
吉岡由貴栄, 松原博文, 松原博文, 今井貴彦, 岡なつみ, 中村信介, 嶋澤雅光, 原英彰. マウス脳梗塞モデルに対するISRIBの神経保護作用. 脳循環代謝(Web). 2021. 33. 1
松原博文, 今井貴彦, 辻翔平, 岡なつみ, 江頭裕介, 中村信介, 嶋澤雅光, 岩間亨, 原英彰. ナファモスタットはマウスくも膜下出血後の早期脳損傷を抑制する. 脳循環代謝(Web). 2021. 33. 1
濱田修作, 高須蒼生, 山本拓平, 山本拓平, 宮城清弦, 中村信介, 嶋澤雅光, 原英彰, 江坂幸宏, 江坂幸宏. LVSEP-CZE Analysis of Dicarboxylic Acids in Mouse Retina. バイオメディカル分析科学シンポジウム講演要旨集. 2021. 33rd
西中杏里, 田中美留豊, 井上雄有輝, 増田智美, 今井貴彦, 山本拓実, 中村信介, 嶋澤雅光, 原英彰. 眼内血管疾患に対するアディポネクチンの作用. 日本眼薬理学会プログラム・講演抄録集. 2021. 40th

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Patents (41)：

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Books (4)：

なにはともあれ元気が一番! : 知って損なし脳・心・からだ・くすりのお話
岐阜薬科大学薬効解析学研究室,アンデパンダン (発売) 2019 ISBN:9784991037405
パートナー機能形態学 : ヒトの成り立ち
南江堂 2018 ISBN:9784524403554
前向き脳でエンジョイ・エイジング! : 長寿の秘訣は脳の健康から
学文社 2011 ISBN:9784762021671
医薬品開発論
廣川書店 2010 ISBN:9784567397704

Lectures and oral presentations (74)：

カリジノゲナーゼの抗VEGF作用
(日本眼薬理学会プログラム・講演抄録集 2010)
A calpain inhibitor protects against light-induced photoreceptor degeneration
(JOURNAL OF PHARMACOLOGICAL SCIENCES 2010)
網膜疾患治療の現状とアミロイドβの関与
(日本薬理学雑誌 2009)
EDARAVONE, A FREE RADICAL SCAVENGER, PROTECTS AGAINST RETINAL DAMAGE IN VITRO AND IN VIVO
(JOURNAL OF NEUROCHEMISTRY 2009)
NEUROPROTECETIVE EFFECT OF EDARAVONE AGAINST LIGHT-INDUCED RETINAL DEGENERATION IN MICE
(JOURNAL OF NEUROCHEMISTRY 2009)

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Professional career (1)：

Ph.D. (Gifu Pharmaceutical University)

Work history (8)：

2021/04 - 現在 Gifu Pharmaceutical University President
2013/04 - 2021/03 Gifu Pharmaceutical University Vice President
2012 - 2021/03 Gifu Pharmaceutical University
2004 - 2021/03 Gifu Pharmaceutical University
1999 - 2004 Santen Pharmaceutical Co Ltd. Ophthalmic Research Center

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