Rchr
J-GLOBAL ID:201801001583998106   Update date: Sep. 29, 2023

Hara Satoshi

ハラ サトシ | Hara Satoshi
Affiliation and department:
Job title: 助教
Research field  (1): Zoological sciences
Research keywords  (3): ゲノム編集 ,  エピジェネティクス ,  ゲノムインプリンティング
Research theme for competitive and other funds  (5):
  • 2023 - 2026 Investigation of molecular mechanisms for overgrowth and aberrant hypermethylation using H19-ICR mutant mouse panel
  • 2022 - 2025 Exploring a novel function of nuclear transport molecules in male and female gametogenesis and elucidation of the infertility mechanism
  • 2019 - 2022 IG-DMR母方欠失マウスにおいて周産期致死を引き起こす責任配列の探索
  • 2017 - 2019 ヒト配列ノックインマウスを用いたIG-DMRによるインプリント制御機構の解析
  • 2015 - 2017 ゲノム編集効率に寄与するマウス受精卵のDNA修復機構の解明
Papers (21):
  • Saori Aoki, Ken Higashimoto, Hidenori Hidaka, Yasufumi Ohtsuka, Shigehisa Aoki, Hiroyuki Mishima, Koh-ichiro Yoshiura, Kazuhiko Nakabayashi, Kenichiro Hata, Hitomi Yatsuki, et al. Aberrant hypomethylation at imprinted differentially methylated regions is involved in biparental placental mesenchymal dysplasia. Clinical Epigenetics. 2022. 14. 1
  • Hidenobu Soejima, Satoshi Hara, Takashi Ohba, Ken Higashimoto. Placental Mesenchymal Dysplasia and Beckwith-Wiedemann Syndrome. Cancers. 2022. 14. 22. 5563-5563
  • Feifei Sun, Satoshi Hara, Chiyoko Tomita, Yuka Tanoue, Hitomi Yatsuki, Ken Higashimoto, Hidenobu Soejima. Phenotypically concordant but epigenetically discordant monozygotic dichorionic diamniotic twins with Beckwith-Wiedemann syndrome. American Journal of Medical Genetics Part A. 2021. 185. 10. 3062-3067
  • Satoshi Hara, Miho Terao, Atsumi Tsuji-Hosokawa, Yuya Ogawa, Shuji Takada. Humanization of a tandem repeat in IG-DMR causes stochastic restoration of paternal imprinting at mouse Dlk1-Dio3 domain. Human Molecular Genetics. 2021. 30. 7. 564-574
  • Ken Higashimoto, Hijiri Watanabe, Yuka Tanoue, Hidefumi Tonoki, Tomoharu Tokutomi, Satoshi Hara, Hitomi Yatsuki, Hidenobu Soejima. Hypomethylation of a centromeric block of ICR1 is sufficient to cause Silver-Russell syndrome. Journal of Medical Genetics. 2020. jmedgenet-2020
more...
MISC (4):
  • 小林 広香, 佐藤 麗, 豊田 雅士, 梅澤 明弘, 山下 聡, 原 聡史, 高田 修治, 黒田 雅彦. ゲノム編集技術を用いた、難治性疾患の分子機構解明に向けた検討. 東京医科大学雑誌 = The Journal of Tokyo Medical University. 2016. 74. 2. 205-206
  • 原 聡史, 川原 玲香, 尾畑 やよい, 河野 友宏. マウス卵母細胞におけるゲノム刷込みの分子機構. The Journal of Reproduction and Development. 2013. 106. 0. AW-6-AW-6
  • YAMAKAMI Reina, OGATA Mio, HARA Satoshi, OBATA Yayoi, KONO Tomohiro. Ectopic expression of DNMT3A and DNMT3L results in lethality by 16 weeks of age in mice. 2013. 30. 2. S103
  • HARA Satoshi, MATSUMOTO Takashige, OBATA Yayoi, KONO Tomohiro. Expression of Dnmt3a2/Dnmt3L is essential but not sufficient for establishment of maternal imprinting during oocyte growth. 2012. 29. 2. S57
Education (2):
  • 2009 - 2014 Tokyo University of Agriculture Graduate School of Agriculture Department of Bio-Science
  • 2005 - 2009 Tokyo University of Agriculture Faculty of Applied Bio-Science Department of Bio-Science
Professional career (1):
  • 博士(バイオサイエンス)
Work history (2):
  • 2019/05 - 現在 Saga University Faculty of Medicine
  • 2014/04 - 2019/04 国立成育医療研究センター システム発生・再生医学研究部 研究員
Awards (3):
  • 2017/09 - SRD Outstanding Paper Award 2016
  • 2013/09 - 日本繁殖生物学会 優秀発表賞
  • 2012/05 - 日本卵子学会 学術奨励賞(口頭発表)
Association Membership(s) (3):
THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  日本エピジェネティクス研究会 ,  SOCIETY FOR REPRODUCTION AND DEVELOPMENT
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