Rchr
J-GLOBAL ID:201801001808636047   Update date: Oct. 15, 2024

Yamamoto Junpei

ヤマモト ジュンペイ | Yamamoto Junpei
Affiliation and department:
Job title: 准教授
Research field  (3): Functional biochemistry ,  Biochemistry ,  Biophysics
Research keywords  (6): 分子進化 ,  Photobiology ,  Nucleic Acids Chemistry ,  Photolyase ,  DNA damage ,  DNA repair
Research theme for competitive and other funds  (15):
  • 2021 - 2028 DNA修復反応の動的構造解析基盤の創出
  • 2022 - 2027 ハンチントン病 CAG リピート異常伸長の促進因子の探索
  • 2023 - 2026 マルチスケール時間分解X線結晶構造解析による酵素学2.0の開拓
  • 2022 - 2024 二元機能性青色光受容タンパク質の光応答機構
  • 2021 - 2023 生体深部の光遺伝子治療を可能にする革新的光応答人工DNA修復酵素の開発
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Papers (55):
  • Kazuki Matsubara, Shouta Ueda, Junpei Yamamoto, Shigenori Iwai, Narumi Aoki Shioi, Arato Takedachi, Isao Kuraoka. Structure-specific DNA endonuclease T7 endonuclease I cleaves DNA containing UV-induced DNA lesions. The Journal of Biochemistry. 2024. 176. 1. 35-42
  • Manuel Maestre-Reyna, Po-Hsun Wang, Eriko Nango, Yuhei Hosokawa, Martin Saf, Antonia Furrer, Cheng-Han Yang, Eka Putra, Gusti Ngurah Putu, Wen-Jin Wu, et al. Visualizing the DNA repair process by a photolyase at atomic resolution. Science. 2023. 382. eadd7795
  • Yuhei Hosokawa, Hiroyoshi Morita, Mai Nakamura, Junpei Yamamoto. A deazariboflavin chromophore kinetically stabilizes reduced FAD state in a bifunctional cryptochrome. Scientific Reports. 2023. 13. 16682
  • Naoto Shimizu, Yusaku Hamada, Ryosuke Morozumi, Junpei Yamamoto, Shigenori Iwai, Kei-ichi Sugiyama, Hiroshi Ide, Masataka Tsuda. Repair of topoisomerase 1-induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2) is dependent on its magnesium binding. Journal of Biological Chemistry. 2023. 104988-104988
  • Manuel Maestre-Reyna, Cheng-Han Yang, Eriko Nango, Wei-Cheng Huang, Eka Putra Gusti Ngurah Putu, Wen-Jin Wu, Po-Hsun Wang, Sophie Franz-Badur, Martin Saft, Hans-Joachim Emmerich, et al. Serial crystallography captures dynamic control of sequential electron and proton transfer events in a flavoenzyme. NATURE CHEMISTRY. 2022. 14. 677-685
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MISC (9):
  • Dynamic control of sequential electron and proton transfer events in a flavoenzyme captured at SACLA. SPring-8/SACLA Information. 2023. 28. 2. 113-118
  • 佐藤竜馬, 森義治, 松井理紗, 沖本憲明, 山元淳平, 泰地真弘人. Theoretical Analyses for DNA Repair Function of Cryptochrome-DASH. 生物物理(Web). 2022. 62. 2
  • 山元淳平. (6-4)光回復酵素によるDNA認識および修復機構. 日本核酸化学会誌. 2018. 2. 21-25
  • Junpei Yamamoto, Pascal Plaza, Klaus Brettel. Repair of (6-4) Lesions in DNA by (6-4) Photolyase: 20 Years of Quest for the Photoreaction Mechanism. PHOTOCHEMISTRY AND PHOTOBIOLOGY. 2017. 93. 1. 51-66
  • Junpei Yamamoto. A proposal for a novel DNA repair mechanism by the (6-4) photolyase. Radiation Biology Research Communications. 2015. 50. 2. 174-184
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Lectures and oral presentations  (40):
  • Enhanced light-driven DNA repair by a photolyase bearing an artificial light-harvesting chromophore
    (The 18th International Congress on Photobiology 2024)
  • Visualizing the DNA repair process by DNA photolyase at attic resolution via time-resolved serial femtosecond X-ray crystallography
    (Supra FIBER International Summit for Nucleic Acids 2024)
  • 時分割シリアルフェムト秒X線結晶構造解析によるDNA光回復酵素の全修復過程の原子分解能観測
    (日本放射線影響学会第66回年次大会 2023)
  • 時分割X線結晶構造解析で捉えたDNA光回復酵素によるDNA修復過程
    (第23回日本光生物学協会年会 2023)
  • 二元機能性動物類縁型クリプトクロムの 光活性化過程の動的構造解析
    (令和5年度新学術領域研究「高速分子動画」シンポジウム 2023)
more...
Education (2):
  • 2005 - 2009 Osaka University Graduate School of Engineering Science Department of Materials Engineering Science Division of Chemistry
  • 2001 - 2005 Osaka University School of Engineering Science Direct Affiliates Department of Chemical Sciece and Engineering
Professional career (1):
  • 博士(理学) (大阪大学)
Work history (7):
  • 2021/04 - 現在 JST創発的研究支援事業 研究者
  • 2019/07 - 現在 Graduate School of Engineering Science Associate Professor
  • 2017/04 - 2019/06 Osaka University Graduate School of Engineering Science Lecturer
  • 2009/10 - 2017/03 Osaka University Graduate School of Engineering Science Asistant professor
  • 2014/09 - 2014/11 CEA Saclay Visiting researcher
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Committee career (1):
  • 2018/03 - 2020/02 日本化学会近畿支部 幹事
Awards (3):
  • 2014/09 - The Biophysical Society of Japan The 10th young researcher award
  • 2012/11 - The 39th International Symposium on Nucleic Acids Chemistry Outstanding Oral Presentation Award
  • 2009/09 - The 6th International Symposium on Nucleic Acids Chemistry Best Poster Award (Nucleic Acids Research Award)
Association Membership(s) (4):
THE JAPAN SOCIETY OF NUCLEIC ACIDS CHEMISTRY ,  THE BIOPHYSICAL SOCIETY OF JAPAN ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  THE CHEMICAL SOCIETY OF JAPAN
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