Fujiwara Hironobu

Affiliation and department：
Job title： Team Leader

Research field (2)： Dermatology , Developmental biology

Research keywords (6)： Epithelial-mesenchymal interactions , Development and Regeneration , Cell-cell communications , Stem cells , Skin , Extracellumar matrix

Research theme for competitive and other funds (16)：

2023 - 2028 Integration of extracellular information by multimodal ECM activity
2023 - 2028 領域研究「細胞外情報を統御するマルチモーダルECM」の統括と運営
2023 - 2028 基底膜ダイナミクスが駆動する器官形成の制御機構
2022 - 2025 Analysis of vasculature matrix in tumor microenvironment
2019 - 2025 体表多様性を創発する上皮-間充織相互作用の動的制御機構の解明

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Papers (28)：

Duligengaowa Wuergezhen, Eleonore Gindroz, Ritsuko Morita, Kei Hashimoto, Takaya Abe, Hiroshi Kiyonari, Hironobu Fujiwara. An eGFP-Col4a2 mouse model reveals basement membrane dynamics underlying hair follicle morphogenesis. The Journal of cell biology. 2025. 224. 2
Itsuki Shioka, Ritsuko Morita, Rei Yagasaki, Duligengaowa Wuergezhen, Tadahiro Yamashita, Hironobu Fujiwara, Satoru Okuda. Ex vivo SIM-AFM measurements reveal the spatial correlation of stiffness and molecular distributions in 3D living tissue. Acta biomaterialia. 2024
Hironobu Fujiwara. Dynamic duo: Cell-extracellular matrix interactions in hair follicle development and regeneration. Developmental biology. 2024. 516. 20-34
Tianchi Xin, Sara Gallini, Haoyang Wei, David G Gonzalez, Catherine Matte-Martone, Hiroki Machida, Hironobu Fujiwara, H Amalia Pasolli, Kathleen C Suozzi, Lauren E Gonzalez, et al. Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation. Nature cell biology. 2024
Jun Yokota, Takamasa Gomi, Yasuko Harada, Kazuyuki Yo, Kyungmin Ahn, Noriko Sanzen, Hiroki Machida, Yuki Shirai, Hironobu Fujiwara. Constructing a Single-Cell Transcriptome Atlas of the Hair Cycle to Decipher Tissue Regeneration Dynamics in Human Skin. SSRN. 2024

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MISC (15)：

森田梨津子, 藤原裕展. 毛包幹細胞の起源を1細胞解析で捉える. 細胞. 2023. 55. 7. 376-379
森田梨津子, 藤原裕展. 仮説と戦略「組織幹細胞の起源の探索」. 生体の科学. 2022. 73. 2. 179-184
筒井仰, 藤原裕展. 多様な異種組織間の相互作用を仲介する毛包基底膜の構造と機能. バイオサイエンスとインダストリー. 2021. 79. 6. 467-471
森田梨津子, 藤原裕展. 毛包幹細胞の発生起源の解明. 実験医学. 2021. 39. 16. 2585-2589
藤原裕展. 表皮幹細胞がニッチとして機能する. 再生医療. 2020. 19. 1. 13-27

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Patents (2)：

基底膜のリアルタイム可視化法
器官の周期状態を推定する方法

Books (3)：

毛髪科学の新展開
シーエムシー出版 2019
わかりやすい感覚器疾患
日本医師会 2018
幹細胞研究と再生医療
南山堂 2013

Lectures and oral presentations (43)：

Multicellular and ECM dynamics underlying skin morphogenesis
(International Society for Stem Cell Research, Singapore International Symposium, Singapore 2024)
Spatial regulation of extracellular matrix turnover rates guides macro-scale organ shape in mouse skin
(EMBO Workshop Molecular Mechanisms of Development and Regeneration, Kobe, Japan 2024)
Spatial regulation of basement membrane turnover rates guides macro-scale organ shape in mouse skin
(NCBS-RIKEN BDR Joint Symposium, Bangalore, India 2024)
Spatial regulation of basement membrane turnover rates guides macro-scale organ shape in mouse skin
(56th Annual Meeting of the Japanese Society for Matrix Biology, Tsukuba, Japan 2024)
Spatial regulation of basement membrane turnover rates guides macro-scale organ shape in mouse skin
(MELIS-UPF & RIKEN BDR Joint Symposium 2024 , Barcelona, Spain 2024)

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Education (3)：

2000 - 2003 大阪大学大学院理学研究科生物科学専攻博士後期課程
1998 - 2000 大阪大学大学院理学研究科生物科学専攻博士前期課程
1994 - 1998 Kyoto Pharmaceutical University Pharmaceutical Sciences Pharmaceutical Biology

Professional career (1)：

Ph.D. (Osaka University)

Work history (14)：

2023/04 - 現在 Kwansei Gakuin University Graduate School of Science and Technology Visiting professor
2023/04 - 現在 MEXT KAKENHI Grant-in-Aid for Transformative Research Area (A) "Multimodal ECM" Leader
2022/04 - 現在 Kyoto University Visiting Professor
2019/10 - 現在 JST CREST Multicell Principal Investigator
2018/04 - 現在 RIKEN Center for Biosystems Dynamics Research Team Leader

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Committee career (8)：

2022 - 現在 Matrix Biology Plus Editorial Board Member
2022 - 現在 Matrix Biology Editorial Board Member
2018/04 - 現在日本研究皮膚科学会理事
2018 - 現在 Journal of Dermatological Science Editorial Board Member
2017/04 - 現在毛髪科学研究会世話人

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Awards (4)：

2022/03 - RIKEN RIKEN Eiho Award
2011 - EMBO Conference Advances in Stem Cell Research Poster Prize First-place winner
2010 - EMBO European Workshop on Skin Stem Cells Poster Prize Sole winner
2010 - 62回日本細胞生物学会若手優秀発表賞

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