Rchr
J-GLOBAL ID：201801002488640578   Update date: Jul. 25, 2024

Ohkawara Bisei

Ohkawara Bisei
Research field  (1)： Developmental biology
Research keywords  (5)： Neuromuscular Junction ,  Synapse Formation ,  Developmental Biology ,  Wnt ,  Signaling pathways
Research theme for competitive and other funds  (20)：
  • 2021 - 2023 Role of Ccn family proteins in adult neuromuscular junctions
  • 2020 - 2023 Pathological analysis of limb girdle congenital myasthenia and development of new therapy
  • 2020 - 2023 Elucidation of molecular mechanisms of neuromuscular junction formations in physiology and pathology
  • 2022 - 2023 神経筋接合部の形態形成における細胞膜融合たんぱく質群の役割
  • 2019 - 2022 Development of a new therapeutic drug for osteoarthritis that has a cartilage-protecting effect by inhibiting Wnt/ADAM10
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Papers (80)：
  • Yuichi Miyairi, Bisei Ohkawara, Ayato Sato, Ryusuke Sawada, Hisao Ishii, Hiroyuki Tomita, Taro Inoue, Hiroaki Nakashima, Mikako Ito, Akio Masuda, et al. A class of chemical compounds enhances clustering of muscle nicotinic acetylcholine receptor in cultured myogenic cells. Biochemical and biophysical research communications. 2024. 731. 150400-150400
  • Hiroto Funahashi, Masaki Matsushita, Ryusaku Esaki, Kenichi Mishima, Bisei Ohkawara, Yasunari Kamiya, Yasuhiko Takegami, Kinji Ohno, Hiroshi Kitoh, Shiro Imagama. Long-term oral meclozine administration improves survival rate and spinal canal stenosis during postnatal growth in a mouse model of achondroplasia in both sexes. JBMR plus. 2024. 8. 4. ziae018
  • Bisei Ohkawara, Masaomi Kurokawa, Akinori Kanai, Kiyomi Imamura, Guiying Chen, Ruchen Zhang, Akio Masuda, Koichi Higashi, Hiroshi Mori, Yutaka Suzuki, et al. Transcriptome profile of subsynaptic myonuclei at the neuromuscular junction in embryogenesis. Journal of neurochemistry. 2024. 168. 4. 342-354
  • Bisei Ohkawara, Hiroyuki Tomita, Taro Inoue, Shaochuan Zhang, Shunsuke Kanbara, Hiroyuki Koshimizu, Yuki Miyasaka, Jun-Ichi Takeda, Hiroshi Nishiwaki, Hiroaki Nakashima, et al. Calcitriol ameliorates motor deficits and prolongs survival of Chrne-deficient mouse, a model for congenital myasthenic syndrome, by inducing Rspo2. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2024. 21. 2. e00318
  • Bisei Ohkawara, Hiroyuki Tomita, Taro Inoue, Shaochuan Zhang, Shunsuke Kanbara, Hiroyuki Koshimizu, Yuki Miyasaka, Jun-Ichi Takeda, Hiroshi Nishiwaki, Hiroaki Nakashima, et al. Calcitriol ameliorates motor deficits and prolongs survival of Chrne-deficient mouse, a model for congenital myasthenic syndrome, by inducing Rspo2. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2024. 21. 2. e00318
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MISC (3)：
Patents (1)：
  • 軟骨細胞のWnt/β-カテニンシグナル伝達経路の活性化抑制組成物及び変形性関節症治療用医薬
Lectures and oral presentations  (8)：
  • 神経筋接合部形成における細胞外分泌因子の役割
    (第6回日本筋学会学術集会 2020)
  • Wnt/beta-catenin signaling in chondrocytes for cartilage degradation of osteoarthritis
    (The Molecular Biology Society of Japan 2018)
  • Mianserin suppresses R-spondin 2-induced activation of Wnt/β-catenin signaling in chondrocytes and prevents cartilage degradation in a rat model of osteoarthritis
    (European Wnt Meeting 2018 2018)
  • CTGF binds to LRP4 to ameliorate NMJ formation
    (Gurdon Conference, Wnt meeting 2017)
  • Mutations in LRP4 in congenital myasthenia reveal position-specific regulations of agrin and Wnt signaling of LRP4
    (Neuroscience 2013 2013)
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Education (3)：
  • 1999 - 2002 The Graduate University for Advanced Studies Life Science Basic Biology
  • 1997 - 1999 Tokyo University of Science Biological Science & Technology Biological Science and Technology, Master course
  • 1993 - 1997 Tokyo University of Science Biological Science & Technology Biological Science and Technology
Work history (7)：
  • 2022/04 - 2023/06 東海国立大学機構 名古屋大学 Graduate School of Medicine
  • 2017/04 - 2021/03 Nagoya University Graduate School of Medicine Division of Neurogenetics Associate Professor
  • 2013/02 - 2017/04 Nagoya University Graduate School of Medicine Division of Neurogenetics Lecturer
  • 2010/11 - 2013/01 Nagoya University Graduate School of Medicine Division of Neurogenetics Assistant Professor
  • 2005/11 - 2010/10 German Cancer Research Center Molecular Embryology Postdoc
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Association Membership(s) (3)：
日本発生生物学会 ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  Japan Muscle Society
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