Saito Shigeru

Affiliation and department：
Job title： Associate Professor
Other affiliations (1)：

National Institute for Physiological Sciences Department of Cell Signaling Associate Professor (concurrent post)

Homepage URL (1)： https://sites.google.com/view/shigeru-saito

Research field (1)： Evolutionary biology

Research keywords (2)： Amphibian , Thermosensitive TRP channel

Research theme for competitive and other funds (5)：

2022 - 2025 The molecular basis and evolutionary mechanism for thermal response behaviors related to habitat selection in amphibians
2019 - 2022 Evolutionary mechanisms for thermal perception associated with the spatio-temporal niche diversification in amphibians
2016 - 2018 古代温度センサーの復元と、ゲノム編集を用いた温度感覚の進化機構の解明
2011 - 2013 侵害性機械刺激受容体の同定とトランスジェニックフライを用いた機能解析
2008 - 2010 恒温動物の体温調節機構の進化:温度感覚と非震え熱産生機構に関る遺伝子の比較解析

Papers (34)：

A Yoshimura, S Saito, C T Saito, K Takahashi, M Tominaga, T Ohta. Functional analysis of thermo-sensitive TRPV1 in an aquatic vertebrate, masu salmon (Oncorhynchus masou ishikawae). Biochemistry and biophysics reports. 2022. 31. 101315-101315
Shigeru Saito, Claire T Saito, Takeshi Igawa, Nodoka Takeda, Shohei Komaki, Toshio Ohta, Makoto Tominaga. Evolutionary Tuning of Transient Receptor Potential Ankyrin 1 Underlies the Variation in Heat Avoidance Behaviors among Frog Species Inhabiting Diverse Thermal Niches. Molecular biology and evolution. 2022. 39. 9
Takeshi Yokoyama, Shigeru Saito, Misato Shimoda, Masakazu Kobayashi, Yoko Takasu, Hideki Sezutsu, Yoshiomi Kato, Makoto Tominaga, Akira Mizoguchi, Kunihiro Shiomi. Comparisons in temperature and photoperiodic-dependent diapause induction between domestic and wild mulberry silkworms. Scientific reports. 2021. 11. 1. 8052-8052
R Uzura, K Takahashi, S Saito, M Tominaga, T Ohta. Reduction of extracellular sodium evokes nociceptive behaviors in the chicken via activation of TRPV1. Brain research. 2020. 1747. 147052-147052
Kohei Ohnishi, Shigeru Saito, Toru Miura, Akane Ohta, Makoto Tominaga, Takaaki Sokabe, Atsushi Kuhara. OSM-9 and OCR-2 TRPV channels are accessorial warm receptors in Caenorhabditis elegans temperature acclimatisation. Scientific reports. 2020. 10. 1. 18566-18566

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MISC (22)：

齋藤茂. 両生類の高温忌避行動の適応進化. 月刊「細胞」. 2023. 7月号
Shigeru Saito. 脊椎動物における温度受容機構の進化的変化と環境適応のつながり. Low Temperature Science. 2023. 81. 71. 71-80
齋藤茂, 齋藤茂. 脊椎動物の温度感受性TRPチャネルの進化的な変化と環境適応. 医学のあゆみ. 2019. 270. 10
齋藤茂, 齋藤茂, 富永真琴, 富永真琴. Functional Changes and Their Structural Basis for Thermal Sensor TRP Channels Related to Evolutionary Adaptation. 生物物理(Web). 2019. 59. 1
Erkin Kurganov, Shigeru Saito, Claire T. Saito, Makoto Tominaga. Binding of Extracellular Ca2+ to the Specific Amino Acids is Required for Heat-Evoked Activation of TRPA1. BIOPHYSICAL JOURNAL. 2017. 112. 3. 113A-113A

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Lectures and oral presentations (13)：

リュウキュウカジカガエルの高温耐性獲得に関連した温度受容システムの進化的変化
(日本進化学会大会プログラム・講演要旨集(Web) 2018)
脊椎動物における温度受容機構の進化:表皮で発現する温度受容体の比較解析
(日本解剖学会総会・全国学術集会講演プログラム・抄録集 2018)
生息環境に応じた温度感覚の進化:分子から生態までの統合的理解を目指して
(日本進化学会大会プログラム・講演要旨集(Web) 2017)
祖先配列の再構築によるツメガエル高温センサーの機能進化過程の推定
(日本進化学会大会プログラム・講演要旨集(Web) 2016)
生息環境に応じた温度感覚を生み出す分子基盤:ツメガエル近縁種間の比較解析を例にして
(日本進化学会大会プログラム・講演要旨集(Web) 2015)

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Education (3)：

1999 - 2004 Tokyo Metropolitan University
1997 - 1999 Tokyo Metropolitan University
1993 - 1997 Hirosaki University

Work history (6)：

2023/07 - 現在 Nagahama Institute of Bio-Science and Technology Department of Animal Bioscience Associate Professor
2015/12 - 2023/06 National Institute for Physiological Sciences
2010/12 - 2015/11 National Institute for Physiological Sciences Department of Cell Signaling Assistant Professor
2009/04 - 2010/11 National Institute for Physiological Sciences
2005/04 - 2009/03 Iwate University Faculty of Engineering

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Awards (5)：

2017/09 - 日本動物学会奨励賞温度感覚の種間多様性とその分子基盤の解明
2014/08 - 第16回日本進化学会大会優秀口頭発表賞温度センサー分子の機能変化による温度感覚の進化機構 :至適温度が異なるツメガエル種間の比較解析
2013/08 - 日本進化学会研究奨励賞分子進化学および生理学的手法による温度受容体の機能進化の研究
2013/03 - 第90回日本生理学会大会佐川喜一賞(ポスター賞) TRPA1チャネルの侵害性の温度・化学物質感受性における脊椎動物種間の多様性
2007/06 - 15th Annual Meeting of the Society for Molecular Biology & Evolution Postdoctoral Poster Prize (1st Prize) Positive Darwinian selection drives rapid evolution of uncoupling protein-1 and conferred novel nonshivering thermogenesis on eutherian mammals

Association Membership(s) (4)：

Society for Molecular Biology & Evolution , THE PHYSIOLOGICAL SOCIETY OF JAPAN , THE ZOOLOGICAL SOCIETY OF JAPAN , SOCIETY OF EVOLUTIONARY STUDIES, JAPAN

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