Shibata Takehiko

Affiliation and department：
Other affiliations (2)：

National Institute of Infectious Diseases
Toho University Graduate School of Science

Homepage URL (1)： http://microbiol-tmed.umin.jp/index.html

Research field (5)： Immunology , Respiratory medicine , Infectious disease , Virology , Bacteriology

Research keywords (14)： Infectious diseases , Immune regulation , 重症化 , Gas6/Axlシグナル , RSV , インフルエンザ , 免疫老化 , 気管支喘息 , COPD , マクロファージ , サイトカイン , vaccine , 肺炎球菌 , 真菌

Research theme for competitive and other funds (9)：

2021 - 2024 新規免疫制御因子Gas6/Axlによる免疫老化の制御に関する研究
2022 - 2024 重症感染症を引き起こす鼻咽頭定着肺炎球菌の増殖機構の解明
2019 - 2021 The mechanism of RSV-induced exacerbation of asthma
2016 - 2019 The role of Gas6/Axl signal in the immune response associated with RSV infection
2016 - 2018 RSウイルス感染による二次性細菌感染の誘導機構の解明

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Papers (11)：

Airi Makino, Takehiko Shibata, Mashiro Nagayasu, Ikuo Hosoya, Toshiyo Nishimura, Chihiro Nakano, Kisaburo Nagata, Toshihiro Ito, Yoshimasa Takahashi, Shigeki Nakamura. RSV infection-elicited high MMP-12-producing macrophages exacerbate allergic airway inflammation with neutrophil infiltration. iScience. 2021. 24. 10. 103201-103201
Takehiko Shibata, Airi Makino, Ruiko Ogata, Shigeki Nakamura, Toshihiro Ito, Kisaburo Nagata, Yoshihiko Terauchi, Taku Oishi, Mikiya Fujieda, Yoshimasa Takahashi, et al. Respiratory syncytial virus infection exacerbates pneumococcal pneumonia via Gas6/Axl-mediated macrophage polarization. Journal of Clinical Investigation. 2020. 130. 6. 3021-3037
Takehiko Shibata, Manabu Ato. A critical role of Gas6/Axl signal in allergic airway responses during RSV vaccine-enhanced disease. Immunology and Cell Biology. 2017. 95. 10. 906-915
Takehiko Shibata, Cory M. Hogaboam. Gas6’ing the Innate Immune Response during Experimental Asthma. Annals of the American Thoracic Society. 2014. 11. Supplement 5. S303-S305
Takehiko Shibata, Ugur Burcin Ismailoglu, Nicolai A. Kittan, Ana Paula Moreira, Ana Lucia Coelho, Geoffrey L. Chupp, Steven L. Kunkel, Nicholas W. Lukacs, Cory M. Hogaboam. Role of Growth Arrest-Specific Gene 6 in the Development of Fungal Allergic Airway Disease in Mice. American Journal of Respiratory Cell and Molecular Biology. 2014. 51. 5. 615-625

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MISC (7)：

近藤庄太郎, 大脇恵人, 柴田岳彦, 犬飼達也, 中村茂樹. 真菌感染症の重症化メカニズムの解明 Growth arrest-specific 6(Gas6)/Axlに着目して. 東京医科大学雑誌. 2022. 80. 4. 352-353
中野千裕, 細谷育央, 細谷育央, 小高倫生, 押尾剛志, 森田浩嗣, 廣内尚智, 山田有佳, 柴田岳彦, 中村茂樹, et al. Exacerbation of emphysema model mice caused by respiratory syncytial virus infection. 日本呼吸器学会誌(Web). 2022. 11
柴田岳彦, 細谷育央, 中村茂樹. Mechanism of exacerbation of elastase-induced emphysema associated with influenza virus infection. 日本呼吸器学会誌(Web). 2022. 11
柴田岳彦, 柴田岳彦, 高橋宜聖, 阿戸学, 伊藤利洋, 中村茂樹. Respiratory syncytial virus infection exacerbates pneumococcal pneumonia via Gas6/Axl-mediated macrophage polarization. 日本呼吸器学会誌(Web). 2021. 10
柴田岳彦, 柴田岳彦, 柴田岳彦, 牧野愛璃, 牧野愛璃, 高橋宜聖, 伊藤利洋, 中村茂樹. RSV infection-evoked MMP-12 exacerbates allergic airway inflammation with neutrophil infiltration. 日本呼吸器学会誌(Web). 2021. 10

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Work history (9)：

2021/04 - 現在国立感染症研究所治療薬・ワクチン開発研究センター協力研究員
2020/04 - 現在 Tokyo Medical University
2018/04 - 現在 Toho University Graduate School of Science
2020/04 - 2021/03 国立感染症研究所免疫部協力研究員
2018/04 - 2020/03 国立感染症研究所免疫部主任研究官

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Association Membership(s) (4)：

日本細菌学会 , 日本呼吸器学会 , 日本感染症学会 , 日本免疫学会

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