Research theme for competitive and other funds (10):
2025 - 2028 Elucidation of the pathological mechanism of desmoplastic reaction characterization in colorectal cancer with a focus on the interaction between cancer cells and cancer-associated fibroblasts
2023 - 2026 A multi-omics investigation of novel therapeutic strategies for clear cell carcinoma of the ovary focusing on cancer metabolism
2022 - 2025 エリスロポエチン産生を誘導する薬剤および遺伝子多型の検出技術開発
2022 - 2025 難治性婦人科癌のマルチオミックス解析による病態解明
2022 - 2025 Exploration of drug-reactive genomic biomarkers for fluoropyrimidine anticancer drug treatment
2023 - 2024 5-フルオロウラシル系抗がん剤代謝酵素の代謝機構メカニズムの解明
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Papers (56):
Mohamed Y. Eljonid, Fumiyoshi Okazaki, Eiji Hishinuma, Naomi Matsukawa, Sahar Hamido, Yutaka Tamaru. Proteomic Characterization of the Clostridium cellulovorans Cellulosome and Noncellulosomal Enzymes with Sorghum Bagasse. International Journal of Molecular Sciences. 2025. 26. 23. 11728-11728
Yuki Ohmori, Eiji Hishinuma, Yuma Suzuki, Akiko Ueda, Caroline Mwendwa Kijogi, Tomoki Nakayoshi, Akifumi Oda, Sakae Saito, Shu Tadaka, Kengo Kinoshita, et al. Comprehensive functional characterization of rare and known CYP2E1 allelic variants identified in a Japanese population. Biochemical Pharmacology. 2025. 117396-117396
Reema Saleous, Eiji Hishinuma, Zeina N. Al-Mahayri, Akiko Ueda, Yuma Suzuki, Mohammad A. Ghattas, Radwa E. Mahgoub, Masahiro Hiratsuka, Bassam R. Ali. Evaluation of the functional impact of rare CYP2C19 missense variants identified in understudied Populations: An Integrated in silico and in vitro analysis. Biochemical Pharmacology. 2025. 117350-117350
Masato Takase, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Sayuri Tokioka, Kotaro Nochioka, Tomohiro Nakamura, Naho Tsuchiya, et al. Association of circulating metabolites and polygenic risk score with incident type 2 diabetes: a prospective community-based cohort study. Cardiovascular diabetology. 2025. 24. 1. 335-335
Tomoyuki Iwasaki, Hidekazu Shirota, Eiji Hishinuma, Shinpei Kawaoka, Naomi Matsukawa, Yuki Kasahara, Kota Ouchi, Hiroo Imai, Ken Saijo, Keigo Komine, et al. Plasma Lysophosphatidylcholine Levels Correlate with Prognosis and Immunotherapy Response in Squamous Cell Carcinoma. International Journal of Molecular Sciences. 2025. 26. 15. 7528-7528
菱沼英史, 上田昭子, 鈴木祐眞, 仲吉朝希, 小田彰史, 齋藤さかえ, 田高周, 木下賢吾, 平塚真弘. Functional changes in variant enzymes derived from CYP2C19 genetic polymorphisms in Japanese individuals. 日本薬学会年会要旨集(Web). 2025. 145th
大森悠生, 菱沼英史, 上田昭子, 鈴木祐眞, 佐藤裕, 平塚真弘. Functional analysis of variant enzymes derived from CYP2J2 genetic polymorphisms that are responsible for myocardial protection. 日本薬学会年会要旨集(Web). 2025. 145th
高橋大輝, 水野文人, 仲吉朝希, 加藤紘一, 加藤紘一, 菱沼英史, 平塚真弘, 平塚真弘, 栗本英治, 小田彰史. Structual analysis of wild-type and mutant dihydropyrimidinases dimer using molecular dynamics simulation. 日本薬学会年会要旨集(Web). 2025. 145th
2022/03 - Biocrates Life Sciences AG Biocrates publishing Editor’s Choice Award Wide-Targeted Metabolome Analysis Identifies Potential Biomarkers for Prognosis Prediction of Epithelial Ovarian Cancer