Rchr
J-GLOBAL ID：201801003384682070
Update date: Oct. 18, 2024
Kurosawa Toshiki
Kurosawa Toshiki
Affiliation and department：
Homepage URL (1)：
https://www.bbb-teikyo.com/
Research field (1)：
Clinical pharmacy
Research keywords (6)：
Blood-brain barrier (BBB)
, Blood-cerebrospinal fluid barrier (BCSFB)
, Transporter
, Organic cation transporter
, human iPS cells
, pharmacokinetics
Research theme for competitive and other funds (4)：
- 2024 - 2027 ヒト脳関門の統合評価システムBrain-MPSの構築
- 2022 - 2025 Creation and clinical application of 3D brain barrier chips using human iPS cells
- 2021 - 2024 ヒト脳微小環境を再現するヒトiPS細胞由来血液脳関門マイクロチップの構築と評価
- 2019 - 2022 Functional elucidation of human blood-brain barrier using iPS-derived brain microvascular entdothelial cells
Papers (13)：
-
Yasuyuki Debori, Tomoko Igari, Masanori Nakakariya, Hideki Hirabayashi, Kazunobu Aoyama, Nobuyuki Amano, Toshiki Kurosawa, Yoshiyuki Kubo, Yoshiharu Deguchi. Involvement of Proton-Coupled Organic Cation Antiporter in Human Blood-Brain Barrier Transport of Mesoridazine and Metoclopramide. Biological & pharmaceutical bulletin. 2024. 47. 10. 1662-1667
-
Tomoko Yamaguchi, Daiki Sako, Toshiki Kurosawa, Misae Nishijima, Ayaka Miyano, Yoshiyuki Kubo, Sumio Ohtsuki, Kenji Kawabata, Yoshiharu Deguchi. Development and Functional Evaluation of MDR1-Expressing Microvascular Endothelial-Like Cells Derived from Human iPS Cells as an In Vitro Blood-Brain Barrier Model. Journal of pharmaceutical sciences. 2023
-
Kurosawa T, Yuma Tega, Yasuo Uchida, Higuchi K, Tabata H, Sumiyoshi T, Yoshiyuki Kubo, Tetsuya Terasaki, Yoshiharu Deguchi. Proteomics-Based Transporter Identification by the PICK Method: Involvement of TM7SF3 and LHFPL6 in Proton-Coupled Organic Cation Antiport at the Blood-Brain Barrier. Pharmaceutics. 2022. 14. 8. 1683-1683
-
Toshiki Kurosawa, Daiki Sako, Yuma Tega, Yasuyuki Debori, Yumi Tomihara, Kazunobu Aoyama, Yoshiyuki Kubo, Nobuyuki Amano, Yoshiharu Deguchi. Construction and Functional Evaluation of a Three-Dimensional Blood-Brain Barrier Model Equipped With Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells. Pharmaceutical Research. 2022
-
Atsushi Kitamura, Kei Higuchi, Toshiki Kurosawa, Takashi Okura, Yoshiyuki Kubo, Yoshiharu Deguchi. Naltrexone Transport by a Proton-Coupled Organic Cation Antiporter in hCMEC/D3 Cells, an in Vitro Human Blood-Brain Barrier Model. Biological & pharmaceutical bulletin. 2022. 45. 10. 1585-1589
ｍore...
MISC (29)：
-
Toshiki Kurosawa, Daiki Sako, Yoshiyuki Kubo, Yoshiharu Deguchi. Establishment of a Human iPS Cell-Derived Blood-Brain Barrier Model to Assess Drug Delivery to the Brain. Journal of Pharmaceutical Science and Technology, Japan. 2024. 84. 3. 146-150
-
Toshiki Kurosawa, Daiki Sako, Yoshiyuki Kubo, Yoshiharu Deguchi. Construction of human iPS cells-derived blood-brain barrier model and evaluation of transporter function. Drug Delivery System. 2023. 38. 2. 117-124
-
黒澤俊樹. 若手が取り組む動態研究「トランスポーターの機能から見るヒトiPS細胞由来血液脳関門モデルの有用性」. 日本薬物動態学会 ニュースレター. 2022. 37. 4. 9-14
-
佐孝 大樹, 黒澤 俊樹, 山口 朋子, 久保 義行, 川端 健二, 出口 芳春. P-gp発現ヒトiPS細胞由来脳毛細血管内皮細胞における輸送体機能評価. 日本薬学会年会要旨集. 2022. 142年会. 28C-pm05S
-
黒澤俊樹, 手賀悠真, 佐孝大樹, 出堀泰之, 冨原裕美, 天野信之, 出口芳春. Construction of 3D BBB model using brain microvascular endothelial cells derived from human induced pluripotent stem cells. 日本薬剤学会年会講演要旨集(CD-ROM). 2021. 36th
ｍore...
Lectures and oral presentations (35)：
-
ヒト脳脊髄液関門モデル細胞 HIBCPP細胞株の機能評価
(日本薬剤学会第39年会)
-
ヒトiPS細胞由来血液脳関門モデルにおける中分子ペプチドの膜動輸送の評価
(日本薬剤学会第39年会)
-
ヒト不死化脈絡叢上皮細胞株HIBCPP細胞における輸送体発現および物質輸送能の評価
(日本薬学会第144年会 2024)
-
ヒトiPS細胞由来血液脳関門モデルを用いたD-angiopep-2輸送機構の評価
(日本薬学会第144年会 2024)
-
ヒトiPS細胞由来血液脳関門モデルを用いた輸送解析およびMPS構築への応用
(CBI学会2023年大会、フォーカストセッション FS06「先端的計測技術」 2023)
ｍore...
Professional career (1)：
Work history (2)：
- 2020/04 - 現在 Teikyo University Faculty of Pharmaceutics Sciences Assistant Professor
- 2018/07 - 2020/03 Teikyo University Faculty of Pharmaceutics Sciences Teaching Associate
Awards (1)：
- 2019/10 - 第41回 生体膜と薬物の相互作用シンポジウム 優秀発表賞 ヒトiPS細胞由来脳毛細血管内皮細胞における6-mercaptopurineの輸送機構解析
Association Membership(s) (3)：
The Academy of Pharmaceutical Science and Technology, Japan
, The Pharmaceutical Society of Japan
, The Japanese Society for the Study of Xenobiotics
