Komai Toshihiko

コマイトシヒコ | Komai Toshihiko

Research field (1)： Allergies and connective tissue disease

Research theme for competitive and other funds (6)：

2022 - 2025 マルチオームシングルセル解析を用いた自己免疫疾患における加齢関連T細胞の機能解析
2022 - 2025 全身性強皮症の病態制御におけるTGF-β3の役割の解明
2019 - 2022 Elucidation of pathogenesis of autoimmune-mediated interstitial lung disease based on epigenomic analysis
2019 - 2022 アルギニンセンサーGATSL3を介した液性免疫制御機構の解明
2018 - 2020 GlaxoSmithKline Research Grant 2018

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Papers (55)：

Shinji Izuka, Parikshit Sen, Toshihiko Komai, Keishi Fujio, Johannes Knitza, Latika Gupta. Digital approaches in myositis. Health Policy and Technology. 2024
Shinji Izuka, Natsuka Umezawa, Toshihiko Komai, Yusuke Sugimori, Naoki Kimura, Fumitaka Mizoguchi, Yuichiro Fujieda, Keita Ninagawa, Takeshi Iwasaki, Katsuya Suzuki, et al. The muscle tissue transcriptome of idiopathic inflammatory myopathy reflects the muscle damage process by monocytes and presence of skin lesions. Arthritis & rheumatology (Hoboken, N.J.). 2024
Ayaka Iwata, Juri Maruyama, Shibata Natsuki, Akira Nishiyama, Tomohiko Tamura, Minoru Tanaka, Shigeyuki Shichino, Takao Seki, Toshihiko Komai, Tomohisa Okamura, et al. Egr2 drives the differentiation of Ly6Chi monocytes into fibrosis-promoting macrophages in metabolic dysfunction-associated steatohepatitis in mice. Communications biology. 2024. 7. 1. 681-681
Shinji Izuka, Toshihiko Komai, Takahiro Itamiya, Mineto Ota, Yasuo Nagafuchi, Hirofumi Shoda, Kosuke Matsuki, Kazuhiko Yamamoto, Tomohisa Okamura, Keishi Fujio. Machine learning-driven immunophenotypic stratification of mixed connective tissue disease corroborating the clinical heterogeneity. Rheumatology (Oxford, England). 2024
駒井俊彦. 糖鎖修飾のリウマチ性疾患における役割. リウマチ科. 2024. 71. 3. 317-320

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MISC (10)：

藤尾圭志, 仲地真一郎, 土田優美, 住友秀次, 駒井俊彦, 井上眞璃子, 照屋周造, 森田薫, 岡村僚久, 山本一彦. Human Immunologyの病態から治療 LAG3陽性制御性T細胞とTGF-β3の病態への関与と疾患制御への可能性. 日本臨床免疫学会会誌. 2015. 38. 4. 234-234
Y. Takeshima, Y. Iwasaki, R. Kato, S. Sumitomo, H. Shirai, B. Natsumoto, M. Otal, S. Teruya, H. Tsuchiya, T. Komai, et al. IMMUNOSUPPRESSIVE THERAPY IS PROMISING FOR PULMONARY ARTERIAL HYPERTENSION ASSOCIATED WITH CONNECTIVE TISSUE DISEASE (CTD-PAH). ANNALS OF THE RHEUMATIC DISEASES. 2015. 74. 1079-1079
藤尾圭志, 岡村僚久, 井上眞璃子, 森田薫, 駒井俊彦, 岩崎由希子, 仲地真一郎, 住友秀次, 山本一彦. 自己免疫疾患のメカニズム全身性自己免疫疾患を抑制するサイトカインによるB細胞制御. 日本リウマチ学会総会・学術集会プログラム・抄録集. 2015. 59回. 227-227
竹島雄介, 岩崎由希子, 加藤里佳, 住友秀次, 白井晴己, 夏本文輝, 太田峰人, 照屋周造, 土屋遥香, 駒井俊彦, et al. リウマチ性疾患の合併症当院における膠原病合併肺動脈性肺高血圧症に対する免疫抑制療法の有用性. 日本リウマチ学会総会・学術集会プログラム・抄録集. 2015. 59回. 357-357
Tomohisa Okamura, Kaoru Morita, Mariko Inoue, Toshihiko Komai, Yukiko Iwasaki, Shuji Sumitomo, Shinichiro Nakachi, Hirofumi Shoda, Keishi Fujio, Kazuhiko Yamamoto. TGF-beta 3-Producing CD4(+) CD25-LAG3(+) Regulatory T Cells Control B Cell Responses. ARTHRITIS & RHEUMATOLOGY. 2014. 66. S380-S380

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Patents (2)：

B細胞活性化の抑制剤及び自己免疫疾患の治療剤
ANTI-TGF-beta3 ANTIBODY AND USE THEREOF

Books (1)：

生物学的製剤適正使用ガイド : 病態理解に沿った治療選択
クリニコ出版 2021 ISBN:9784910396101

Lectures and oral presentations (20)：

Inhibitory cytokine synergy of IL-10 and TGF-β3 contributes to humoral immune tolerance mediated by metabolic reprogramming
(The 63rd Annual General Assembly and Scientific Meeting of the Japan College of Rheumatology 2019)
Cytokine-mediated immune tolerance via mitochondrial reprogramming
(The 47th Annual Meeting of the Japanese Society for Immunology 2018)
Immunological significance of the dual secretion of TGF-β3 and IL-10 from regulatory T cells.
(The 45th Annual Meeting of the Japanese Society for Immunology, Okinawa 2016)
TGF-βとIL-10によるエネルギー代謝修飾を介した液性免疫制御機構
(第3回ベーシックリサーチカンファレンス, 日本リウマチ学会 2016)
Synergistic immunoregulatory roles and mechanisms of TGF-β3 with IL-10 in systemic autoimmunity
(International Concurrent Workshop, JCR2016 2016)

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Awards (12)：

2020/09 - APLAR2020 Excellent Abstract Award Therapeutic effects of plasma exchange for refractory interstitial lung diseases in clinically amyopathic dermatomyositis
2020/04 - JCR2020_ICW Excellent Abstract Award Protective roles of TGF-β3 in interstitial pneumonia with autoimmune features
2019/04 - Japan College of Rheumatology 2019 ICW Excellent Abstract Award
2016/12 - Japanese Society for Immunology Best Presentation Award, The 45th Annual Meeting of the Japanese Society for Immunology
2016/12 - 日本免疫学会 Ursula and Fritz Melchers Travel Award

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