Rchr
J-GLOBAL ID：201801003883584373
Update date: Oct. 25, 2024
Hoshino Hidekazu
ホシノ ヒデカズ | Hoshino Hidekazu
Affiliation and department：
Research keywords (3)：
改変ポリメラーゼ
, アプタマー
, 核酸医薬
Research theme for competitive and other funds (2)：
- 2023 - 2026 画期的なアンチセンス核酸創薬のための新技術に関する研究
- 2019 - 2024 糖部修飾型人工核酸アプタマー創出に向けた基盤技術の構築
Papers (7)：
-
Luis F. Avila-Cobian, Stefania De Benedetti, Hidekazu Hoshino, Van T. Nguyen, Amr M. El-Araby, Safaa Sader, Daniel D. Hu, Sara L. Cole, Choon Kim, Jed F. Fisher, et al. Lytic transglycosylase Slt of Pseudomonas aeruginosa as a periplasmic hub protein. Protein Science. 2024. 33. 7
-
Hidekazu Hoshino, Yuuya Kasahara, Satoshi Obika. Polyamines promote xenobiotic nucleic acid synthesis by modified thermophilic polymerase mutants. RSC Chemical Biology. 2024. 5. 5. 467-472
-
Kenta Ishida, Yuuya Kasahara, Hidekazu Hoshino, Takumi Okuda, Satoshi Obika. Systematic Analysis of 2′-O-Alkyl Modified Analogs for Enzymatic Synthesis and Their Oligonucleotide Properties. Molecules. 2023. 28. 23. 7911-7911
-
Luis F. Avila-Cobian, Hidekazu Hoshino, Mark E. Horsman, Van T. Nguyen, Yuanyuan Qian, Rhona Feltzer, Choon Kim, Daniel D. Hu, Matthew M. Champion, Jed F. Fisher, et al. Amber-codon suppression for spatial localization and in vivo photoaffinity capture of the interactome of the Pseudomonas aeruginosa Rare Lipoprotein A (RlpA) lytic transglycosylase. Protein Science. 2023. 32. 10. e4781
-
Hidekazu Hoshino, Yuuya Kasahara, Masayasu Kuwahara, Satoshi Obika. DNA Polymerase Variants with High Processivity and Accuracy for Encoding and Decoding Locked Nucleic Acid Sequences. Journal of the American Chemical Society. 2020. 142. 51. 21530-21537
ｍore...
Patents (2)：
Lectures and oral presentations (22)：
-
Development of the polymerase mutants towards screening of functional oligonucleotides using bridged nucleic acids containing an amide bond or a guanidino group
(The 20th Annual Oligonucleotide Therapeutics Society Meeting 2024)
-
アミド結合あるいはグアニジノ基を架橋部位に有する糖部架橋型人工核酸を伸長可能な改変ポリメラーゼの開発と性能評価
(日本核酸医薬学会第9回年会 2024)
-
LNA以外の糖部架橋型人工核酸に適用可能な改変ポリメラーゼの開発
(日本薬学会第144年会 2024)
-
PD-1に対する糖部修飾型人工核酸アプタマーの開発
(日本核酸医薬学会第8回年会 2023)
-
ポリアミンによる人工核酸の酵素伸長への影響
(日本薬学会第143年会 2023)
ｍore...
Education (3)：
- 2013 - 2016 Osaka University Graduate School of Pharmaceutical Sciences
- 2011 - 2013 東京理科大学大学院 総合科学研究科(博士前期課程)
- 2007 - 2011 Tokyo University of Science Faculty of Science, Division 1 Chemistry
Professional career (1)：
- Ph.D. of Pharmaceutical Science (Osaka University)
Work history (4)：
- 2022/11 - 現在 National Institutes of Biomedical Innovation, Health and Nutrition Project researcher
- 2020/10 - 2022/10 University of Notre Dame Department of Chemistry and Biochemistry Postdoctoral Research Associate
- 2020/10 - 2022/10 National Institutes of Biomedical Innovation, Health and Nutrition
- 2016/04 - 2020/09 National Institutes of Biomedical Innovation, Health and Nutrition
Awards (1)：
- 2024/10 - The 20th Annual Oligonucleotide Therapeutics Society Meeting Travel Grant Development of the polymerase mutants towards screening of functional oligonucleotides using bridged nucleic acids containing an amide bond or a guanidino group
Association Membership(s) (2)：
Return to Previous Page
