Rchr
J-GLOBAL ID：201801004371800585   Update date: Apr. 11, 2024

Heishima Kazuki

ヘイシマ カズキ | Heishima Kazuki
Affiliation and department：
Gifu University

About Gifu University


Job title： G-YLC (the Young Leaders Cultivating program)-designated assistant professor
Other affiliations (1)：
Research field  (4)： Experimental pathology ,  Molecular biology ,  Tumor biology ,  Veterinary medicine
Research keywords  (9)： ペタシン ,  Mitochondrial metabolism ,  Cancer metabolism ,  NGS解析 ,  オミクス解析 ,  Histopathology ,  Cancer Biology ,  Comparative Oncology ,  MicroRNA
Research theme for competitive and other funds  (4)：
  • 2022 - 2025 N/A
  • 2021 - 2023 N/A
  • 2021 - 2022 高活性ミトコンドリア呼吸鎖複合体I阻害剤であるペタシンの標的分子の同定
  • 2020 - 2022 Development of miR-143-lipid nanoparticle-based therapy against KRAS-mutant multiple myeloma
Papers (39)：
  • Hemangiosarcoma in dogs as a potential non-rodent animal model for drug discovery research of angiosarcoma in humans. Frontiers in Oncology. 2023. 13
  • Jun Arima, Kohei Taniguchi, Nobuhiko Sugito, Kazuki Heishima, Yoshihisa Tokumaru, Yosuke Inomata, Kazumasa Komura, Tomohito Tanaka, Masa-Aki Shibata, Sang-Woong Lee, et al. Antitumor effects of chemically modified miR-143 lipoplexes in a mouse model of pelvic colorectal cancer via myristoylated alanine-rich C kinase substrate downregulation. Molecular Therapy - Nucleic Acids. 2023. 34. 102079-102079
  • Kazuki Heishima, Nobuhiko Sugito, Chikara Abe, Akihiro Hirata, Hiroki Sakai, Yukihiro Akao. Targeting microRNA-145-mediated progressive phenotypes of early bladder cancer in a molecularly defined in vivo model. Molecular Therapy - Nucleic Acids. 2023. 33. 960-982
  • Junko Maeda, Ben Jepson, Kohei Sadahiro, Mami Murakami, Hiroki Sakai, Kazuki Heishima, Yukihiro Akao, Takamitsu A Kato. PARP deficiency causes hypersensitivity to Taxol through oxidative stress induced DNA damage. Mutation research. 2023. 827. 111826-111826
  • Atsushi Satake, Shingo Minatoguchi, Kazuki Heishima, Shinji Yasuda, Hirotaka Murase, Ryo Yoshizumi, Hisaaki Komaki, Shinya Baba, Shinsuke Ojio, Toshiki Tanaka, et al. An Increase in Plasma MicroRNA-143 Levels in the Acute Phase Is Positively Correlated With Recovery of Cardiac Function in the Chronic Phase in Patients With Acute Myocardial Infarction. Circulation Journal. 2023
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MISC (3)：
Patents (2)：
  • 血管病変の評価方法および血管病変評価用キット
  • 腫瘍細胞におけるアスパラギン酸合成の阻害剤、腫瘍細胞のスフェロイド形成阻害剤、腫瘍細胞の転移抑制剤、解糖系阻害剤の作用増強剤、並びに腫瘍の転移の抑制および/または予防用医薬組成物
Books (1)：
  • 犬腫瘍における血漿中microRNA-214およびmicroRNA-126発現量の検索
    文永堂出版 2016
Lectures and oral presentations  (35)：
  • 動物用医薬品開発を考える
    (動物用医薬品開発検討WG 2024)
  • Impact of interaction with patients through crowdfunding on a young researcher
    (ARO協議会第10回学術集会 2023)
  • フキノトウとミトコンドリア代謝、がんの関係
    (名大発アカデミックフラッシュ 第21報 2023)
  • がんのエネルギー代謝を標的とした分子標的薬開発
    (第4回東海創薬・医療機器開発フォーラム 2023)
  • MicroRNA drug and biomarker development exploiting human-canine homology in angiosarcoma and osteosarcoma
    (The 81st Annual Meeting of the Japanese Cancer Association 2022)
ｍore...
Education (2)：
  • 2013 - 2016 Gifu University
  • 2007 - 2013 Iwate University Veterinary Medicine
Professional career (1)：
  • 博士(獣医学) (岐阜大学)
Work history (8)：
  • 2022/04 - 現在 Nagoya University Institute for Advanced Research
  • 2022/04 - 現在 Gifu University
  • 2022/04 - 現在 Hokkaido University
  • 2022/04 - 現在 Gifu University Institute for Advanced Study Assistant Professor (Young Leaders Cultivation Program, specially appointed)
  • 2018/04 - 2022/03 Gifu University
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Committee career (1)：
  • 2024/02 - 現在 Veterinary and Comparative Oncology Editorial Board
Awards (6)：
  • 2023/01 - Global Young Scientist Symposium 2023 Japan Science and Technology Agency-designated Participant for Global Young Scientist Symposium 2023
  • 2022/08 - Mansfield-PhRMA Research Program Scholar
  • 2022/04 - Tokai Pathways to Global Excellence (T-GEx) Fellow
  • 2016/02 - 日本獣医内科学アカデミー(JCVIM) 研究アワード
  • 2015/09 - 北海道大学 Best Poster Presentation Award (The 3rd SaSSOH)
Show all
Association Membership(s) (5)：
日本毒性病理学会 ,  JAPANESE SOCIETY FOR RADIATION ONCOLOGY ,  Veterinary Cancer Society ,  THE JAPANESE SOCIETY OF VETERINARY SCIENCE ,  THE JAPANESE CANCER ASSOCIATION
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