Komaba Hirotaka

コマバヒロタカ | Komaba Hirotaka

Affiliation and department：
Job title： Professor
Other affiliations (1)：

Tokai University Institute of Medical Sciences Member

Research field (1)： Nephrology

Research keywords (4)： Nephrology , Bone metabolism , 慢性腎臓病に伴う骨・ミネラル代謝異常 , FGF23-Klotho系

Research theme for competitive and other funds (6)：

2022 - 2025 Role of proximal tubular Klotho in regulation of phosphate and vitamin D metabolism
2020 - 2023 急性腎障害が惹起する骨ミネラル代謝異常:疾患概念の確立と病態解明
2020 - 2022 Effect of PTH on energy and glucose metabolism in a mouse model of diabetes
2016 - 2019 The pathophysiological role of FGF23 in disordered mineral metabolism after acute kidney injury
2013 - 2015 Role of FGF23/Klotho system in pathophysiology of chronic kidney disease

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Papers (268)：

Keisuke Soeda, Hirotaka Komaba, Yosuke Nakagawa, Chiaki Kawabata, Takehiko Wada, Hiroo Takahashi, Yuichiro Takahashi, Toru Hyodo, Miho Hida, Takao Suga, et al. Association of serum sodium levels with fractures and mortality in patients undergoing maintenance hemodialysis. Journal of Nephrology. 2024
Yosuke Nakagawa, Hirotaka Komaba. Standardization of PTH measurement by LC-MS/MS: a promising solution for interassay variability. Kidney International. 2024
Akio Nakashima, Yoshia Miyawaki, Hirotaka Komaba, Noriaki Kurita, Yoshihiro Onishi, Takashi Yokoo, Masafumi Fukagawa. Proton pump inhibitors and hyporesponsiveness to erythropoiesis stimulating agents in hemodialysis patients: results from the Japan Dialysis Outcomes and Practice Patterns Study. American journal of nephrology. 2023
Hirotaka Komaba, Junhui Zhao, Angelo Karaboyas, Suguru Yamamoto, Indranil Dasgupta, Mohamed Hassan, Li Zuo, Anders Christensson, Christian Combe, Bruce Robinson M, et al. Active vitamin D use and fractures in hemodialysis patients: Results from the international DOPPS. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2023. 38. 11. 1577-1585
Takeshi Hasegawa, Takahiro Imaizumi, Takayuki Hamano, Kenta Murotani, Naohiko Fujii, Hirotaka Komaba, Masahiko Ando, Shoichi Maruyama, Masaomi Nangaku, Kosaku Nitta, et al. Association between serum iron markers, iron supplementation, and cardiovascular morbidity in pre-dialysis chronic kidney disease. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2023

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Books (5)：

FGF23 and Klotho in Chronic Kidney Disease. Encyclopedia of Bone Biology.
Elsevier 2020
Effect of PTH on the hematologic system. Parathyroid Glands in Chronic Kidney Disease.
Springer Nature 2020
Vitamin D and Klotho in chronic kidney disease. Vitamin D in Chronic Kidney Disease.
Springer 2016
Role of FGF23 in CKD2-5. Mineral and Bone Disorders in Chronic Kidney Disease: Advances in pathogenesis, diagnosis and treatment.
Lippincott Williams & Wilkins 2010
Imaging and intervention of parathyroid hyperplasia. The Spectrum of Mineral and Bone Disorder in Chronic Kidney Disease (Oxford Clinical Nephrology Series)
Oxford University Press 2010

Lectures and oral presentations (91)：

A Look Forward: Clinical Implications of Translational Research in CKD-MBD
(World Congress of Nephrology 2024 2024)
Bone-specific overexpression of membrane Klotho induces FGF23
(2023 Physiology, Biology and Pathology of Phosphate, Gordon Research Conference 2023)
Active vitamin D use and fractures in hemodialysis patients: Results from the international DOPPS
(Kidney Week 2022, the American Society of Nephrology 2022)
CKD-MBDにおける骨粗鬆症治療のあり方
(日本骨粗鬆症学会雑誌 2022)
骨ミネラル代謝の新知見急速に進化するCKD-MBDの治療戦略
(日本腎臓学会誌 2022)

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Education (2)：

2006 - 2010 Kobe University Graduate School of Medicine
1997 - 2003 Kobe University School of Medicine

Professional career (1)：

Ph.D. (Kobe University Graduate School)

Work history (10)：

2024/04 - 現在 Tokai University School of Medicine
2016/04 - 現在 Tokai University Institute of Medical Sciences
2019/04 - 2024/03 Tokai University School of Medicine
2015/12 - 2024/03 Tokai University School of Medicine
2016/04 - 2019/03 Tokai University School of Medicine

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Committee career (21)：

2023/12 - 現在日本腎臓財団 J-DOPPS ステアリング委員
2023/07 - 現在日本骨代謝学会臨床プログラム推進委員会
2022/08 - 現在日本透析医学会医療安全対策小委員会
2021/07 - 現在日本透析医学会慢性腎臓病に伴う骨・ミネラル代謝異常の診療ガイドライン改訂ワーキンググループ
2020/08 - 現在日本腎臓財団 J-DOPPS 第7期公募論文推進支援グループ

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Awards (13)：

2022/06 - 東海大学医学部優秀研究ユニット賞
2022/06 - 日本腎臓学会 Clinical Scientist Award
2020/06 - 東海大学医学部優秀研究ユニット賞
2019/10 - AJKD Reviewer Hall of Fame
2019/10 - 日本骨代謝学会研究奨励賞

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Association Membership(s) (7)：

International Society of Nephrology , American Society of Nephrology , Japanese Society for Bone and Mineral Research , Japanese Society for Dialysis Therapy , Japanese Society of Nephrology , Japanese Society of Internal Medicine , Japan Osteoporosis Society

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