HAYATO TAMAI

Affiliation and department：

Research field (3)： Tumor diagnostics and therapeutics , Immunology , Hematology and oncology

Research keywords (5)： KMT2A , mixed lineage leukemia , MLL , 11q23 , acute lymphoblastic leukemia

Research theme for competitive and other funds (5)：

2023 - 2026 Establishment of the combined treatment of hematopoietic stem cells transplantation and S100A6 inhibitors to KMT2A/AFF1 positive acute lymphoblastic leukemia
2016 - 2017 MLL/AF4陽性急性リンパ性白血病の腫瘍免疫の回避を標的とする新規治療の研究
2014 - 2017 新規RCSD1-ABL1 遺伝子癌化能と分子標的薬開発
2014 - 2016 MLL/AF4 陽性ALL のS100A6 抑制による新規治療開発
2014 - 2015 MLL/AF4陽性急性リンパ性白血病の新規治療の開発

Papers (42)：

Hayato Tamai, Kenji Tajika, Kazutaka Nakayama, Ayako Arai. Treatment of relapsed aggressive adult T-cell leukemia/lymphoma after allogeneic hematopoietic stem cell transplantation with mogamulizumab followed by lenalidomide. Bone Marrow Transplantation. 2021
Ikuko Omori, Hiroki Yamaguchi, Tsuneaki Hirakawa, Kazuki Inai, Daishi Onai, Atsushi Marumo, Satoshi Yamanaka, Masahiro Sakaguchi, Yusuke Fujiwara, Satoshi Wakita, et al. Outcomes of Patients with Early Hyperbilirubinemia after Allogeneic Hematopoietic Stem Cell Transplantation. Journal of Nippon Medical School = Nippon Ika Daigaku zasshi. 2020. 87. 3. 142-152
Masahiro Sakaguchi, Kazutaka Nakayama, Hiroki Yamaguchi, Akiko Mii, Akira Shimizu, Kazuki Inai, Daishi Onai, Atsushi Marumo, Ikuko Omori, Satoshi Yamanaka, et al. Risk Factors for Acute Kidney Injury and Chronic Kidney Disease following Allogeneic Hematopoietic Stem Cell Transplantation for Hematopoietic Malignancies. Acta haematologica. 2020. 143. 5. 452-464
Yusuke Fujiwara, Hiroki Yamaguchi, Shunsuke Yui, Taichiro Tokura, Kazuki Inai, Daishi Onai, Ikuko Omori, Atsushi Marumo, Satoshi Yamanaka, Masahiro Sakaguchi, et al. Importance of prognostic stratification via gene mutation analysis in elderly patients with acute myelogenous leukemia. International journal of laboratory hematology. 2019. 41. 4. 461-471
大森郁子, 山口博樹, 尾内大志, 丸毛淳史, 山中聡, 阪口正洋, 藤原裕介, 由井俊輔, 福永景子, 了徳寺剛, et al. 同種造血幹細胞移植における肝障害合併の臨床的意義(Clinical significance of liver injury in the early phase after allogeneic HSCT). 臨床血液. 2018. 59. 9. 1681-1681

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MISC (37)：

玉井勇人, 猪口孝一. Atg7抑制によるAML細胞の抗がん剤感受性増強. 血液内科. 2017. 74. 6. 830-832
尾内大志, 中山一隆, 岡本宗雄, 守屋慶一, 玉井勇人, 岡部雅弘, 平川経晃, 栗林泰子, 木下量介, 阪口正洋, et al. 高齢者de novo AMLに対する減量寛解導入療法"2+5"療法の試み. 老年者造血器疾患研究会会誌. 2017. 25. 12-12
Satoshi Yamanaka, Kazutaka Nakayama, Hayato Tamai, Masanori Sakamaki, Koiti Inokuchi. Adult T-cell leukemia-lymphoma complicated by Takotsubo cardiomyopathy and HTLV-1-associated myelopathy after treatment with the anti-CCR4 antibody mogamulizumab. [Rinsho ketsueki] The Japanese journal of clinical hematology. 2017. 58. 4. 309-314
Hayato Tamai, Hiroki Yamaguchi, Koichi Miyake, Miyuki Takatori, Tomoaki Kitano, Syunsuke Yui, Keiko Fukunaga, Kazutaka Nakayama, Koiti Inokuchi. Amlexanox As a Possible Breakthrough Drug for MLL/AF4 Positive Acute Lymphoblastic Leukemia. BLOOD. 2016. 128. 22
Yusuke Fujiwara, Hiroki Yamaguchi, Atsushi Marumo, Ikuko Omori, Satoshi Yamanaka, Kazuki Terada, Shunsuke Yui, Keiko Fukunaga, Takeshi Ryotokuji, Tsuneaki Hirakawa, et al. Analysis of Genetic Mutation of the Elderly Patients with Acute Myeloid Leukemia. BLOOD. 2016. 128. 22

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Lectures and oral presentations (22)：

Amlexanox併用造血幹細胞移植による切除不能膵癌治療の可能性
(第40回日本造血細胞移植学会総会 2018)
KMT2A/AFF1 (MLL/AF4)陽性急性リンパ性白血病のGVL効果や腫瘍免疫の回避を標的とする新規治療法
(第79回日本血液学会総会 2017)
Amlexanox as a possible breakthrough of MLL/AF4-positive ALL
(第78回日本血液学会総会 2016)
Leukemogenicity of RCSD1-ABL1 of Ph-like acute lymphoblastic leukemia varies between fusion sites
(第 77回日本血液学会総会, 2015)
S100A6発現抑制によりGVL抵抗性のMLL/AF4陽性ALLにGVLを発現できる
(第36回日本造血細胞移植学会総会 2014)

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Education (2)：

2008 - 2012 Nippon Medical School
1996 - 2002 Nippon Medical School Medical School

Professional career (1)：

医学博士 (日本医科大学)

Work history (15)：

2023/07 - 現在 St.Marianna University School of Medicine
2020/06 - 2023/06 St.Marianna University School of Medicine
2017/10 - 2020/05 Nippon Medical School
2017/04 - 2020/05 国家公務員共済組合連合会横浜南共済病院血液内科医長
2015/10 - 2017/03 Nippon Medical School

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Committee career (1)：

2013/10 - 現在日本血液学会評議員

Awards (6)：

2013 - 東京都医師会医学研究賞
2012 - 日本医科大学同窓会賞
2012 - 日本医科大学日本医科大学賞「研究部門」
2012 - 日本医科大学大学院最優秀研究賞
2010 - 日本血液学会 EHA Congress Travel Award

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Association Membership(s) (4)：

日本造血細胞移植学会 , 米国血液学会 , THE JAPANESE SOCIETY OF HEMATOLOGY , THE JAPANESE SOCIETY OF INTERNAL MEDICINE

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