Rchr
J-GLOBAL ID:201801004926936720   Update date: Oct. 25, 2021

KEIJI UCHIYAMA

ウチヤマ ケイジ | KEIJI UCHIYAMA
Affiliation and department:
Research field  (3): Virology ,  Cell biology ,  Pathobiochemistry
Research keywords  (4): 細胞内小器官 ,  membrane trafficking ,  prion ,  neurodegenerative disease
Research theme for competitive and other funds  (18):
  • 2017 - 2020 プリオン感染によるソーティリン発現量低下機構の解明と治療法開発への応用
  • 2017 - 2019 Membrane trafficking involved in the degradation of aged brain protein
  • 2014 - 2017 Development of basic technology for therapy of prion diseases based on Sortilin function
  • 2013 - 2016 プリオン感染によるポストゴルジ小胞輸送障害および神経細胞死誘導機構の解明
  • 2015 - 2016 神経変性疾患における小胞輸送障害に着目した病態機序の解明
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Papers (39):
  • Hideyuki Hara, Junji Chida, Keiji Uchiyama, Agriani Dini Pasiana, Etsuhisa Takahashi, Hiroshi Kido, Suehiro Sakaguchi. Neurotropic influenza A virus infection causes prion protein misfolding into infectious prions in neuroblastoma cells. Scientific Reports. 2021. 11. 1
  • Hideyuki Hara, Junji Chida, Agriani Dini Pasiana, Keiji Uchiyama, Yutaka Kikuchi, Tomoko Naito, Yuichi Takahashi, Junji Yamamura, Hisashi Kuromatsu, Suehiro Sakaguchi. Vaporized Hydrogen Peroxide and Ozone Gas Synergistically Reduce Prion Infectivity on Stainless Steel Wire. International Journal of Molecular Sciences. 2021. 22. 6. 3268-3268
  • Keiji Uchiyama, Hironori Miyata, Yoshitaka Yamaguchi, Morikazu Imamura, Mariya Okazaki, Agriani Dini Pasiana, Junji Chida, Hideyuki Hara, Ryuichiro Atarashi, Hitomi Watanabe, et al. Strain-Dependent Prion Infection in Mice Expressing Prion Protein with Deletion of Central Residues 91-106. International journal of molecular sciences. 2020. 21. 19
  • Junji Chida, Hideyuki Hara, Keiji Uchiyama, Etsuhisa Takahashi, Hironori Miyata, Hidetaka Kosako, Yukiko Tomioka, Toshihiro Ito, Hiroyuki Horiuchi, Haruo Matsuda, et al. Prion protein signaling induces M2 macrophage polarization and protects from lethal influenza infection in mice. PLoS pathogens. 2020. 16. 8. e1008823
  • Nandita Rani Das, Hironori Miyata, Hideyuki Hara, Junji Chida, Keiji Uchiyama, Kentaro Masujin, Hitomi Watanabe, Gen Kondoh, Suehiro Sakaguchi. The N-Terminal Polybasic Region of Prion Protein Is Crucial in Prion Pathogenesis Independently of the Octapeptide Repeat Region. Molecular Neurobiology. 2020. 57. 2. 1203-1216
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MISC (25):
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Patents (1):
  • 分離型混合培養装置
Books (5):
  • Prions: Current Progress in Advanced Research (Second Edition)
    Caister Academic Press 2019
  • Prions - Some Physiological and Pathophysiological Aspects
    IntechOpen 2018
  • Prions: Current progress in advanced research
    Caister Academic Press 2013
  • 生物工学実験書
    The Society for Biotechnology, Japan 2002
  • Microbiology of Composting
    Springer-Verlag 2002
Lectures and oral presentations  (55):
  • Analysis of intracellular secretion processes by Citrine fusion IgG aiming to establish high producer CHO cells.
    (The 31st Annual and International Meeting of the Japanese Association for Animal Cell Technology (JAACT2018 Tsukuba) 2018)
  • High susceptibility of Sortilin-deficient cells to prion infection.
    (第65回日本ウイルス学会学術集会 2017)
  • Identification and investigation of a novel anti-prion compound.
    (第65回日本ウイルス学会学術集会 2017)
  • 高生産株の構築を目指した抗体生産CHO細胞内の分泌過程解
    (第69回日本生物工学会大会 2017)
  • Prion propagation through sortilin degradation.
    (第60回日本神経化学会大会 2017)
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Education (3):
  • 1994 - 1997 大阪大学大学院 醗酵工学専攻博士課程
  • 1992 - 1994 大阪大学大学院 醗酵工学専攻修士課程
  • 1987 - 1992 Osaka University
Professional career (1):
  • 工学博士 (大阪大学)
Work history (8):
  • 2016/04 - 現在 The University of Tokushima
  • 2011/04/01 - 2016/03/31 The University of Tokushima The Institute for Enzyme Research
  • 2007/04/01 - 2011/03 The University of Tokushima The Institute for Enzyme Research
  • 2004/04/01 - 2007/03/31 三菱化学生命科学研究所 主任研究員 研究部門 細胞構造・病態グループ 主任研究員
  • 2003/10 - 2004/03 University of Cambridge Cambridge Institute for Medical Research Senior Research Associate
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Awards (3):
  • 2016/11/12 - The 29th Annual and International Meeting of the Japanese Association for Animal Cell Technology Best Oral Presentation Awards Analysis of intracellular recombinant IgG secretion in engineered CHO cells
  • 2015/09/05 - Asia Pacific Society of Prion Research (APSPR) Asia Pacific Prion Symposium 2015, The Best Poster Award Mechanism of Sortilin-Mediated PrP degradation
  • 2014/01/28 - The Koraku Foundation 康楽賞 プリオン病における神経細胞死誘導機構の解明と治療への応用
Association Membership(s) (5):
Asian Pacific Society of Prion Research (APSPR) ,  The Japanese Society for Virology ,  The Japanese Biochemical Society ,  Japan Society for Cell Biology ,  The Molecular Biology Society of Japan
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