Rchr
J-GLOBAL ID:201801005084778729   Update date: Sep. 17, 2024

Tsumuraya Takeshi

ツムラヤ タケシ | Tsumuraya Takeshi
Affiliation and department:
Job title: Professor
Research field  (3): Chemical biology ,  Molecular biochemistry ,  Biochemistry
Research keywords  (6): biofunctional moletule ,  directed evolution ,  transition-state analog ,  hybridoma ,  monoclonal antibody ,  library
Research theme for competitive and other funds  (23):
  • 2022 - 2025 Development of Caribbean ciguatoxin-specific antibodies for prevention and treatment of ciguatera
  • 2019 - 2022 Development of a trace detection method based on monoclonal antibodies recognizing Carribbean ciguatoxin.
  • 2016 - 2019 Studies toward the total synthesis of Caribbean ciguatoxin for the development of a highly sensitive antibody-based immunoassy
  • 2016 - 2019 A molecular design of molecular-targeting peptides (mid-size medicines) with cell membrane permeability.
  • 2014 - 2017 ホロ酵素型抗体酵素法によるテーラーメイド人工酵素(抗体酵素)の新機能開拓
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Papers (88):
  • Asako Yamaguchi, Hiroaki Aino, Takeshi Tsumuraya, Masahiro Hirama, Ikuo Fujii. Humanization and characterization of an anti-ciguatoxin CTX3C monoclonal antibody. Toxicon : official journal of the International Society on Toxinology. 2024. 247. 107848-107848
  • Toshiaki Yokozeki, Madoka Kawabata, Kazuhiro Fujita, Masahiro Hirama, Takeshi Tsumuraya. Sensitive Detection of Ciguatoxins Using a Neuroblastoma Cell-Based Assay with Voltage-Gated Potassium Channel Inhibitors. Toxins. 2024. 16. 3. 118-118
  • Toshiaki Yokozeki, Yuka Hama, Kazuhiro Fujita, Tomoji Igarashi, Masahiro Hirama, Takeshi Tsumuraya. Evaluation of relative potency of calibrated ciguatoxin congeners by near-infrared fluorescent receptor binding and neuroblastoma cell-based assays. Toxicon. 2023. 230. 107161-107161
  • Giorgio Honsell, Greta Gaiani, Masahiro Hirama, Marco Pelin, Aurelia Tubaro, Takeshi Tsumuraya, Mònica Campàs. Cell immunolocalization of ciguatoxin-like compounds in the benthic dinoflagellate Gambierdiscus australes M. Chinain & M.A. Faust by confocal microscopy. Harmful algae. 2022. 120. 102353-102353
  • Mònica Campàs, Sandra Leonardo, Naomasa Oshiro, Kyoko Kuniyoshi, Takeshi Tsumuraya, Masahiro Hirama, Jorge Diogène. A smartphone-controlled amperometric immunosensor for the detection of Pacific ciguatoxins in fish. Food chemistry. 2022. 374. 131687-131687
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MISC (18):
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Patents (11):
  • シガトキシン類CTX1Bおよび54-デオキシ-CTX1B を認識するモノクローナル抗体およびそれを用いるシガトキシン類検出キット
  • 1. 抗体断片のスクリーニング方法及びアッセイシステム
  • シガトキシン類を認識するヒト化抗体
  • 1. ヒトインターロイキン-5受容体(hIL-5R)結合ペプチド
  • CTX3CのA-E環部をもつハプテン部を有するタンパク質コンジュゲートで免疫して得られるシガトキシンCTX3C抗体およびその作製方法
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Books (7):
  • バイオサイエンス実験:入門から応用へ
    大阪公立大学共同出版会 2016
  • 新機能抗体開発ハンドブック
    NTS 2012
  • 化学フロンティア22:生命現象を理解する分子ツール
    化学同人 2010
  • 産学官連携の研究開発
    中央経済社 2009
  • ナノバイオ大辞典
    テクノシステム 2007
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Lectures and oral presentations  (25):
  • Sandwich ELISA detection of ciguatoxins using anti-ciguatoxin monoclonal antibodies
    (Workshop on Emerging Marine Toxins 2016)
  • 有機合成化学との連携による抗体タンパク質の機能化
    (近畿化学協会ヘテロ原子部会平成28年度第1回談話会 2016)
  • Sandwich ELISA detection of ciguatoxins using anti-ciguatoxin monoclonal antibodies
    (The International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) 2015)
  • Procuction of anti-ciguatoxin monoclonal antibodies using synthetic haptens: sandwich ELISA detection of ciguatoxins
    (Rapid Test Workshop “Rapid Testing for Seafood Contaminants” 2014)
  • Catalytic antibodies with luciferase activity
    (Enzyme Engineering XXII 2013)
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Education (2):
  • 1985 - 1990 University of Tsukuba
  • 1981 - 1985 University of Tsukuba
Work history (11):
  • 2022/04 - 現在 Osaka Metropolitan University Department of Biological Chemistry, Graduate School of Science Professor
  • 2017/04 - 現在 Osaka Prefecture University Graduate School of Science, Department of Biological Science
  • 2007/04 - 2017/03 Osaka Prefecture University Graduate School of Science, Department of Biological Science
  • 2005/04 - 2007/03 Osaka Prefecture University Graduate School of Science, Department of Biological Science
  • 2003/10 - 2005/03 Osaka Prefecture University
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Committee career (13):
  • 2009/02 - 現在 有機合成化学協会 関西支部 幹事
  • 2009/01 - 現在 酵素工学研究会 幹事
  • 2008/03 - 現在 日本化学会 フロンティア生命化学研究会 理事
  • 2008/03 - 現在 コンビナトリアル・バイオエンジニアリング研究会 幹事
  • 2006/01 - 現在 AOAC (The Association of Analytical Communities) International Marine and Freshwater Toxins Task Force Member
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Awards (2):
  • 2002/09 - 日本化学会 第17 回若い世代の特別講演賞
  • 1995/01 - 日本化学会 第68日本化学会秋季年会講演賞
Association Membership(s) (14):
THE CRYSTALLOGRAPHIC SOCIETY OF JAPAN ,  コンビナトリアル・バイオエンジニアリング研究会 ,  Japanese Society of Enzyme Engineering ,  Protein Society ,  PROTEIN SCIENCE SOCIETY OF JAPAN ,  AOAC (The Association of Analytical Communities) International ,  KINKI CHEMICAL SOCIETY, JAPAN ,  The Japanese Peptide Society ,  The Society for Biotechnology, Japan ,  日本化学会 フロンティア生命化学研究会 ,  THE PHARMACEUTICAL SOCIETY OF JAPAN ,  American Chemical Society ,  THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN ,  THE CHEMICAL SOCIETY OF JAPAN
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