Rchr
J-GLOBAL ID：201801005228517917
Update date: Sep. 17, 2024
Yoshie Umehara
ウメハラ ヨシエ | Yoshie Umehara
Affiliation and department：
Research field (3)：
Dermatology
, Neuropathology
, Developmental biology
Research theme for competitive and other funds (5)：
- 2016 - 2019 Elucidation of mechanisms of peripheral itch hypersensitivity focusing on dorsal root ganglia and development for its therapeutic application
- 2016 - 2018 Effect of antimicrobial peptide cathelicidin on atopic dermatitis
- 2014 - 2017 Effect of skin-derived antimicrobial peptide cathelicidin LL-37 on the regulation of skin barrier function
- 2014 - 2016 A method to differentiate peripheral neurons mediating itch from human induced pluripotent stem cells
- 2014 - 2016 Cathelicidin LL-37 induces semaphorin 3A expression in human epidermal keratinocytes: implications for possible application to pruritus
Papers (63)：
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梅原 芳恵, Trujillo Valentin, 彭 戈, 岳 海楠, 奥村 康, 小川 秀興, ニヨンサバ・フランソワ. Calcitriolはアトピー性皮膚炎モデルマウスの皮膚バリア機能を改善する. 日本皮膚科学会雑誌. 2024. 134. 5. 1487-1487
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Juan Valentin Trujillo-Paez, Ge Peng, Hai Le Thanh Nguyen, Masahiro Nakamura, Yoshie Umehara, Hainan Yue, Risa Ikutama, Miho Takahashi, Shigaku Ikeda, Hideoki Ogawa, et al. Calcitriol modulates epidermal tight junction barrier function in human keratinocytes. Journal of dermatological science. 2024. 114. 1. 13-23
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Yoshie Umehara, Juan Valentin Trujillo-Paez, Hainan Yue, Ge Peng, Hai Le Thanh Nguyen, Ko Okumura, Hideoki Ogawa, François Niyonsaba. Calcitriol, an Active Form of Vitamin D3, Mitigates Skin Barrier Dysfunction in Atopic Dermatitis NC/Nga Mice. International Journal of Molecular Sciences. 2023. 24. 11. 9347-9347
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Hai Le Thanh Nguyen, Ge Peng, Juan Valentin Trujillo-Paez, Hainan Yue, Risa Ikutama, Miho Takahashi, Yoshie Umehara, Ko Okumura, Hideoki Ogawa, Shigaku Ikeda, et al. The Antimicrobial Peptide AMP-IBP5 Suppresses Dermatitis-like Lesions in a Mouse Model of Atopic Dermatitis through the Low-Density Lipoprotein Receptor-Related Protein-1 Receptor. International Journal of Molecular Sciences. 2023. 24. 6. 5200-5200
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Risa Ikutama, Ge Peng, Saya Tsukamoto, Yoshie Umehara, Juan Valentin Trujillo-Paez, Hainan Yue, Hai Le Thanh Nguyen, Miho Takahashi, Shun Kageyama, Masaaki Komatsu, et al. Cathelicidin LL-37 activates human keratinocyte autophagy through the P2X7, mTOR and MAPK pathways. The Journal of investigative dermatology. 2022
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MISC (80)：
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岳 海楠, 彭 戈, 梅原 芳恵, 奥村 康, 小川 秀興, 池田 志斈, ニヨンサバ・フランソワ. ヒスタミンによって誘発される痒みに対する芳香族炭化水素受容体の関与. 日本皮膚免疫アレルギー学会総会学術大会プログラム・抄録集. 2022. 52回. 185-185
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グエン・レータインハイ, 梅原 芳恵, 奥村 康, 小川 秀興, 池田 志斈, ニヨンサバフランソワ. DNCB誘発皮膚炎様マウスモデルにて、insulin-like growth factor binding protein 5由来抗菌ペプチドは、LRP1受容体を介して皮膚炎症状を改善する(The antimicrobial peptide derived from insulin-like growth factor binding-protein 5 alleviates dermatitis symptoms in the DNCB-induced dermatitis-like mouse model through LRP1 receptor). 日本皮膚免疫アレルギー学会総会学術大会プログラム・抄録集. 2022. 52回. 187-187
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PENG Ge, TSUKAMOTO Saya, UMEHARA Yoshie, OKUMURA Ko, OGAWA Hideoki, IKEDA Shigaku, NIYONSABA Francois, NIYONSABA Francois. Human β defensin-3 alleviates atopic dermatitis-like symptoms through aryl hydrocarbon receptor signaling pathway. アレルギー. 2022. 71. 6/7
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THANH Nguyen Hai Le, PENG Ge, VALENTIN Juan Trujillo-Paez, HAINAN Yue, IKUTAMA Risa, TAKAHASHI Miho, UMEHARA Yoshie, OKUMURA Ko, OGAWA Hideoki, IKEDA Shigaku, et al. The antimicrobial peptide AMP-IBP5 alleviates skin symptoms in a hapten-induced atopic dermatitis-like model. アレルギー. 2022. 71. 6/7
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YUE Hainan, PENG Ge, UMEHARA Yoshie, NGUYEN Hai Le Thanh, TSUKAMOTO Saya, IKEDA Arisa, TRUJILLO-PAEZ Juan Valentin, OKUMURA Ko, OGAWA Hideoki, IKEDA Shigaku, et al. Involvement of the aryl hydrocarbon receptor in histamine-evoked acute itch. 日本研究皮膚科学会年次学術大会・総会プログラム. 2022. 47th
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Patents (1)：
Education (3)：
- 2010 - 2013 北里大学大学院 理学研究科 生物科学専攻 博士課程
- 2008 - 2010 北里大学大学院 理学研究科 生物科学専攻 修士課程
- 2004 - 2008 Kitasato University School of Science
Work history (2)：
- 2018/04 - 現在 順天堂大学大学院医学研究科 アトピー疾患研究センター 助教
- 2013/04 - 2018/03 順天堂大学大学院医学研究科 環境医学研究所 博士研究員
Awards (6)：
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