Kito Hiroaki

キトウヒロアキ | Kito Hiroaki

Affiliation and department：
Homepage URL (1)： http://www.med.nagoya-cu.ac.jp/pharma.dir/index.html

Research field (1)： Pharmacology

Research keywords (2)： osteoblast , イオンチャネル

Research theme for competitive and other funds (7)：

2021 - 2024 内向き整流性カリウムチャネルによる骨形成調節機構の解明とその応用
2020 - 2024 Pathological significance of K+ channel regulation in tumor microenvironment
2018 - 2021 Pathophysiological functions of ion channels in the chronic inflammatory and fibrotic disorders
2018 - 2021 Role of KCa channels in preosteoblast proliferation
2016 - 2019 Molecular mechanisms underlying alternation of ion channel expression and function by chronic inflammation

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Papers (29)：

Susumu Ohya, Hiroaki Kito, Junko Kajikuri, Yohei Yamaguchi, Miki Matsui. Transcriptional Up-Regulation of FBXW7 by KCa1.1 K+ Channel Inhibition through the Nrf2 Signaling Pathway in Human Prostate Cancer LNCaP Cell Spheroid Model. International Journal of Molecular Sciences. 2024. 25. 11. 6019-6019
Hiroaki Kito, Reiko Kawagishi, Takusei Ryu, Kyoko Endo, Junko Kajikuri, Wayne R. Giles, Susumu Ohya. KCa3.1 regulates cell cycle progression by modulating Ca2+signaling in murine preosteoblasts. Journal of Pharmacological Sciences. 2023. 153. 3. 142-152
Susumu Ohya, Miki Matsui, Junko Kajikuri, Hiroaki Kito, Kyoko Endo. Downregulation of IL-8 and IL-10 by the Activation of Ca2+-Activated K+ Channel KCa3.1 in THP-1-Derived M2 Macrophages. International journal of molecular sciences. 2022. 23. 15
Miki Matsui, Junko Kajikuri, Kyoko Endo, Hiroaki Kito, Susumu Ohya. KCa3.1 inhibition-induced activation of the JNK/c-Jun signaling pathway enhances IL-10 expression in peripherally-induced regulatory T cells. Journal of Pharmacological Sciences. 2022. 148. 1. 1-5
Susumu Ohya, Junko Kajikuri, Kyoko Endo, Hiroaki Kito, Miki Matsui. KCa1.1 K+ Channel Inhibition Overcomes Resistance to Antiandrogens and Doxorubicin in a Human Prostate Cancer LNCaP Spheroid Model. International Journal of Molecular Sciences. 2021. 22. 24. 13553-13553

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MISC (10)：

OHYA Susumu, KAJIKURI Junko, ENDO Kyoko, KITO Hiroaki. Role of Ca²⁺-activated K⁺ channel K_Ca1.1 in in vitro model of tumor microenvironment. Journal of Physiological Sciences (Web). 2021. 71. Supplement 1
OHYA Susumu, KAJIKURI Junko, KITO Hiroaki. Patho-physiological significance of Ca²⁺-activated K⁺ channels in tumor microenvironment. Journal of Physiological Sciences (Web). 2020. 70. Supplement 1
OHYA Susumu, MATSUI Miki, MATSUI Miki, KAJIKURI Junko, KITO Hiroaki, ENDO Kyoko, ENDO Kyoko, HASAGAWA Yuki, MURATE Shin-ya. Inhibition of IL-10 transcription by K_Ca3.1 K⁺ channel activation in human T-cell lymphoma. Journal of Physiological Sciences (Web). 2019. 69. Supplement 1
Fujimoto Mayu, Kito Hiroaki, Kajikuri Junko, Ohya Susumu, Ohya Susumu. Transcriptional repression of human epidermal growth factor receptor 2 by ClC-3 Cl^-/H⁺ transporter inhibition in human breast cancer cells. Cancer Science (Web). 2018. 109. 9
OHYA Susumu, KAJIKURI Junko, KITO Hiroaki. Transcriptional repression of IL-10 by K+ channel activators in human T-cell lymphoma HuT-78 cells. 日本癌学会学術総会抄録集(Web). 2018. 77th

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Education (3)：

Professional career (1)：

Work history (5)：

2023/04 - 現在 Nagoya City University Graduate School of Medical Sciences Department of Pharmacology
2018/01 - 2023/03 Nagoya City University Graduate School of Medical Sciences Department of Pharmacology
2014/10 - 2017/12 Kyoto Pharmaceutical University Pharmaceutical Sciences
2014/04 - 2014/09 日本学術振興会特別研究員(PD)
2013/04 - 2014/03 日本学術振興会特別研究員(DC2)

Committee career (1)：

Awards (2)：

Association Membership(s) (4)：

日本癌学会 , 日本薬学会 , 日本生理学会 , 日本薬理学会

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