Rchr

J-GLOBAL ID：201801005462238525 Update date: Jul. 16, 2024

Taguchi Ayumu

Affiliation and department：

Research field (4)： Tumor diagnostics and therapeutics , Tumor biology , Gastroenterology , Molecular biology

Research keywords (23)：消化器がん , Proteomics , 分子プロファイリング , PDXモデル , バイオマーカー , 早期診断 , マルチオミクス解析 , サーフェスオーム , セクレトーム , HLAリガンドーム , リン酸化プロテオーム , Biomarker , 自己抗体 , マイクロRNA , 長鎖ノンコーディングRNA , 大腸癌 , 直腸癌 , 膵癌 , 食道癌 , 胃癌 , 肺癌 , 骨軟部肉腫 , Cancer

Research theme for competitive and other funds (35)：

2023 - 2026 ピリミジン塩基合成経路を標的としたLKB1不活化肺癌に対する新規治療法の開発
2021 - 2026 低侵襲ハイスループット光濃縮システムの開発
2022 - 2025 腹腔洗浄液および末梢血を用いた特異的腹膜再発予測バイオマーカーの確立
2022 - 2025 肝臓癌PDXモデルのリン酸化プロテオーム解析による革新的分子治療標的薬の同定
2022 - 2025 Discovery study of biomarkers of small bowel lesion in Crohn's disease by proteome analysis

2022 - 2025 多層プロテオーム解析による食道癌の新規治療標的探索と術前化学療法効果予測への応用

2022 - 2025 KRAS変異陰性の腸型IPMNおよびコロイド癌におけるドライバー融合遺伝子の探索

2021 - 2024 Spatial proteomic analysis of in vivo and in vitro models of colorectal cancer liver metastasis

2021 - 2024 In depth proteomics-based dynamic profiling of blood proteins for colorectal cancer early detection

2021 - 2024 In depth proteomic profiling of humoral immune response for prediction of response to immune checkpoint blockade

2021 - 2024 Integrative proteomic analysis of PDX models to develop targeted therapies in gastric cancer

2021 - 2024 In depth proteomics to develop novel therapies in non-adenocarcinoma lung cancer

2021 - 2024 Integrative proteomic analysis of PDX models to develop targeted therapies for sarcoma

2020 - 2023 個別化がんワクチン療法に向けた統合プロテオミクスによる新規がん抗原同定法の開発

2020 - 2023 In-depth surfaceome analysis of PDX models to develop innovative personalized therapies in pancreatic cancer

2020 - 2023 Development of clinical micropeptidome in cancer tissues

2020 - 2023 Integrative proteomic analysis of PDX models to develop targeted therapies for colorectal cancer metastasis

2021 - 2023 分泌タンパク質SMOC1を標的としたLKB1不活化肺癌における新規治療戦略の構築

2021 - 2023 高深度血漿プロテオーム解析に基づく新規大腸癌早期診断法の開発

2017 - 2022 Development of Risk and Early Detection Biomarker for Small Cell Lung Cancer

2018 - 2022 Circulating Exosomes as Biomarkers for Lung Cancer Early Detection

2020 - 2022 NASH 肝癌マウスモデルの超高感度マルチオミクス解析による革新的診断マーカー・治療標的の探索

2016 - 2021 Pathogenesis and Early Progression of Lung Cancer

2018 - 2021 Circulating Exosomes as Biomarkers for Lung Cancer Early Detection

2015 - 2020 Integrative molecular profiling for discovery of biomarkers and therapeutic targets in epithelial cancer

2016 - 2019 Incorporating Biomarkers to Improve Lung Cancer Risk Prediction

2016 - 2018 Imaging and Molecular Correlates of Progression in Cystic Neoplasms of the Pancreas

2015 - 2018 Development of a blood-based biomarker panel for indeterminate lung nodules

2015 - 2018 Blood Biomarkers for Lung Cancer Screening, Risk Assessment, and Early Detection

2015 - 2018 Regulation of dormancy of metastatic prostate cancer cells by bone microenvironment

2016 - 2017 Exosomal DNA as a surrogate biomarker for early diagnosis and therapeutic stratification in pancreatic cancer

2016 - 2017 Development of a blood-based biomarker panel for prediction of recurrence in early stage non-small cell lung cancer

2015 - 2016 Blood-based biomarkers for pancreatic cancer early detection

2010 - 2015 Blood Based Biomarkers for Lung Cancer Early Detection and Evaluation of CT Based Lesions

2009 - 2014 Mouse Models of Human Cancer Consortium

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Papers (47)：

Yusuke Okuda, Takaya Shimura, Yuichi Abe, Hiroyasu Iwasaki, Ruriko Nishigaki, Shigeki Fukusada, Naomi Sugimura, Mika Kitagawa, Tamaki Yamada, Ayumu Taguchi, et al. Urinary dipeptidase 1 and trefoil factor 1 are promising biomarkers for early diagnosis of colorectal cancer. Journal of gastroenterology. 2024
Mei-Chee Tai, Leonidas E Bantis, Gargy Parhy, Taketo Kato, Ichidai Tanaka, Chi-Wan Chow, Junya Fujimoto, Carmen Behrens, Tetsunari Hase, Koji Kawaguchi, et al. Circulating microRNA Panel for Prediction of Recurrence and Survival in Early-Stage Lung Adenocarcinoma. International journal of molecular sciences. 2024. 25. 4
Mika Iwai, Taisuke Kajino, Masahiro Nakatochi, Kiyoshi Yanagisawa, Yasuyuki Hosono, Hisanori Isomura, Yukako Shimada, Motoshi Suzuki, Ayumu Taguchi, Takashi Takahashi. Long non-coding RNA TILR constitutively represses TP53 and apoptosis in lung cancer. Oncogene. 2022
Ehsan Irajizad, Johannes F Fahrmann, James P Long, Jody Vykoukal, Makoto Kobayashi, Michela Capello, Chuan-Yih Yu, Yining Cai, Fu Chung Hsiao, Nikul Patel, et al. A Comprehensive Search of Non-Canonical Proteins in Non-Small Cell Lung Cancer and Their Impact on the Immune Response. International journal of molecular sciences. 2022. 23. 16
Ichidai Tanaka, Delphine Dayde, Mei Chee Tai, Haruki Mori, Luisa M Solis, Satyendra C Tripathi, Johannes F Fahrmann, Nese Unver, Gargy Parhy, Rekha Jain, et al. SRGN-Triggered Aggressive and Immunosuppressive Phenotype in a Subset of TTF-1-Negative Lung Adenocarcinomas. Journal of the National Cancer Institute. 2021. 114. 2. 290-301

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MISC (67)：

Samir M. Hanash, Ziding Feng, Ayumu Taguchi. Failure to Disclose Potential Conflict of Interest-Letter of Explanation. JAMA Oncology. 2019. 5. 12. 1811
Robert S. Bresalier, James C. Byrd, Dean E. Brenner, Hans J. Nielsen, Ziding Feng, Suyu Liu, Samir Hanash, Ayumu Taguchi, John A. Baron, Sapna Syngal, et al. A BLOOD-BASED MARKER PANEL FOR DETECTION OF COLORECTAL NEOPLASIA. GASTROENTEROLOGY. 2017. 152. 5. S1316-S1316
Mattias A. Johansson, Ayumu Taguchi, David Muller, Samir Hanash, Paul Brennan. Comprehensive evaluation of promising biomarkers for lung cancer risk prediction. CANCER RESEARCH. 2016. 76
Michela Capello, Leonidas E. Bantis, Ghislaine Scelo, Yang Zhao, Dilsher S. Dhillon, Hong Wang, James L. Abbruzzese, Anirban Maitra, Margaret A. Tempera, Randall Brand, et al. Sequential validation of blood-based protein biomarker candidates for early-stage pancreatic cancer. CANCER RESEARCH. 2016. 76
Johannes F. Fahrmann, Jennifer Dennison, Eunice Murage, Hong Wang, Edwin J. Ostrin, Ayumu Taguchi, Samir Hanash. Elevated kynureninase protein expression is associated with KEAP1 mutant non-small cell lung cancer and is predictive of poor overall survival. CANCER RESEARCH. 2016. 76

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Patents (2)：

Methods for the Detection and Treatment of Pancreatic Cancer
Methods for the Detection and Treatment of Lung Cancer.

Books (1)：

Molecular Oncology: Causes of Cancer and Targets for Treatment.
Cambridge University Press. 2013

Lectures and oral presentations (18)：

クリニカルプロテオミクスが拓くがん研究の近未来
(第53回藤田医科大学医学会シンポジウム 2021)
血液は何を語るのか:光濃縮によるがん早期診断への挑戦
(LAC-SYS 研究所第3回シンポジウム 2021)
クリニカルプロテオミクスとそのがん免疫治療への応用
(第1回Oncology Crosstalk Symposium 2020)
肺がんに迫る分子プロファイリングの今
(とよあけ肺がんセミナー 2019)
血液は何を語るのか~がん早期発見への挑戦~
(瑞穂区医師会学術講演会 2019)

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Education (3)：

2001 - 2005 Nagoya University Graduate School of Medicine
1991 - 1997 Nagoya University School of Medicine
1988 - 1991 東海高校

Work history (10)：

2018/11 - 現在 Nagoya University Graduate School of Medicine
2018/09 - 現在愛知県がんセンター分子診断トランスレーショナルリサーチ分野分野長
2018/04 - 2018/08 テキサス大学大学院 Graduate School of Biomedical Sciences Assistant Professor
2013/11 - 2018/08 MDアンダーソンがんセンター Department of Translational Molecular Pathology Assistant Professor (tenure track)
2012/08 - 2013/10 MDアンダーソンがんセンター Dr. Sam Hanash's Lab ポストドクトラルフェロー

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Awards (3)：

2018 - American Cancer Society Research Scholar Award
2015 - U.S. Department of Defence Lung Cancer Research Program Career Development Award
2008 - 米国がん学会 Scholar-in-Training Award

Association Membership(s) (7)：

JAPANESE SOCIETY OF GASTROINTESTINAL CANCER SCREENING , JAPAN GASTROENTEROLOGICAL ENDOSCOPY SOCIETY , 米国臨床腫瘍学会 , 米国癌学会 , JAPANESE SOCIETY OF GASTROENTEROLOGY , THE JAPANESE SOCIETY OF INTERNAL MEDICINE , THE JAPANESE CANCER ASSOCIATION

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