Okuzumi Ayami

Affiliation and department：

Research field (1)： Neurology

Research keywords (7)：神経変性疾患 , 凝集体 , biomarker , RT-QuiC , propagation , alpha-synuclein , Parkinson's disease

Research theme for competitive and other funds (7)：

2023 - 2027 Pathogenesis of Synucleinopathy Focusing on the Core Structure of Alpha-Synuclein Seeds in the Blood
2023 - 2026 異常タンパク質シードの形成・伝播を捉える脳組織内1分子イメージング技術の開発
2022 - 2026 パーキンソン病患者の運動療法による神経保護効果因子の検証
2021 - 2024 ニューロモデュレーションはαシヌクレイン脳内伝播に影響を及ぼすのか?
2021 - 2024 血清αシヌクレインシードに着眼したシヌクレイノパチーの病態解明と新規治療法の開発

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Papers (49)：

Ayami Okuzumi, Taku Hatano, Nobutaka Hattori. [Mechanisms Underlying the Propagation of α-Synuclein Seeds Derived from the Blood of Patients with α-Synucleinopathies]. Brain and nerve = Shinkei kenkyu no shinpo. 2024. 76. 6. 767-772
Taku Hatano, Ayami Okuzumi, Gen Matsumoto, Tsunemi Taiji, Nobutaka Hattori. α-Synuclein: A Promising Biomarker for Parkinson's Disease and Related Disorders. Journal of movement disorders. 2024. 17. 2. 127-137
Taku Hatano, Genko Oyama, Yasushi Shimo, Kotaro Ogaki, Noriko Nishikawa, Ryota Nakamura, Taiji Tsunemi, Takashi Ogawa, Hiroto Eguchi, Kensuke Daida, et al. Efficacy and Safety of Elobixibat in Parkinson's Disease with Chronic Constipation: CONST-PD Study. Movement disorders clinical practice. 2024. 11. 4. 352-362
Kei-Ichi Ishikawa, Ayami Okuzumi, Hiroyo Yoshino, Nobutaka Hattori, Wado Akamatsu. Generation of hiPSCs (JUCGRMi003-A) from a patient with Parkinson's disease with PARK2 mutation. Stem cell research. 2024. 76. 103323-103323
Hikaru Kamo, Hirokazu Iwamuro, Ryota Nakamura, Shuko Nojiri, Ayami Okuzumi, Takashi Ogawa, Asuka Nakajima, Nobutaka Hattori, Yasushi Shimo. Antagonism of metabotropic glutamate receptor type 5 prevents levodopa-induced dyskinesia development in a male rat model of Parkinson's disease: Electrophysiological evidence. Journal of neuroscience research. 2024. 102. 3. e25302

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MISC (68)：

奥住文美, 波田野琢, 服部信孝. 特集今この研究が面白い! 第8章神経 [Parkinson病]αシヌクレインに焦点を当てた診断バイオマーカーの開発. 内科. 2024. 134. 3. 677-681
奥住文美, 波田野琢, 服部信孝. Parkinson病のバイオマーカー-Biological biomarkers for Parkinson disease-特集 Parkinson病 : 臨床と研究の新展開(その1). 脳神経内科 = Neurology / 脳神経内科編集委員会編. 2024. 100. 3. 268-273
Okuzumi Ayami, Hatano Taku, Hattori Nobutaka. Diagnostic and therapeutic approaches focused on α-synuclein. Neurological Therapeutics. 2024. 41. 3. 362-365
下島健太郎, 王子悠, 若盛亮, 波田野琢, 山口隼司, 奥住文美, 服部信孝. プロサポシン変異マウスにおける中枢神経変性の検討. 日本生化学会大会プログラム・講演要旨集. 2023. 96回. [2P-622]
奥住文美, 波田野琢, 松本弦, 服部信孝. α-シヌクレインシードの伝播凝集メカニズム. 神経治療学. 2023. 40. 6. S254-S254

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Patents (8)：

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Lectures and oral presentations (11)：

Elucidation of the Pathogenesis of Synucleinopathies Focused on Blood Alpha-Synuclein Seeds
(2024)
The main stream "alpha-synuclein pathology"
(2024)
Identification of serum disease-specific a-synuclein seeds using IP/RT-QuIC
(ASENT 2024 Annual Meeting Evaluation 2024)
A Research for mechanism and diagnosis of synucleinopathy based on prion-like seeding hypothesis.
(2023)
Identification of seral disease-specific a-synuclein seeds using IP/RT-QuIC
(2023)

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Education (2)：

2018 - Juntendo University Graduate School of Medicine
2009 - Juntendo University Faculty of Medicine

Professional career (1)：

博士 (順天堂大学大学院)

Work history (2)：

2022/07 - 現在順天堂大学神経学講座准教授
2018 - 2022/06 Juntendo University

Awards (12)：

2024/09 - 2024年度いしがね海老原財団Neuroscience Awards受賞
2024/07 - 順天堂大学医師会学術研究賞
2024/01 - 公益財団法人難病医学研究財団令和5年度医学研究奨励助成金受賞者
2023/08 - International Congress of Parkinson’s Disease and Movement Disorders Junior Awards
2023/05 - 第64回日本神経学会学術大会最優秀ポスター賞

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Association Membership(s) (7)：

Movement Disorder Society , JAPAN SOCIETY FOR DEMENTIA RESEARCH , THE JAPAN NEUROSCIENCE SOCIETY , THE JAPANESE SOCIETY OF NEUROPATHOLOGY , THE JAPAN STROKE SOCIETY , THE JAPANESE SOCIETY OF INTERNAL MEDICINE , JAPANESE SOCIETY OF NEUROLOGY

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