Toshie Kai

Affiliation and department：
Job title： Professor
Homepage URL (2)： http://www.fbs.osaka-u.ac.jp/labs/kai/ , http://www.fbs.osaka-u.ac.jp/labs/kai/en/

Research field (2)： Developmental biology , Molecular biology

Research theme for competitive and other funds (9)：

2025 - 2028 非膜オルガネラ・ヌアージュとRNAヘリカーゼによる生殖細胞ゲノム保護機構
2021 - 2026 Management of non-domain biopolymer research group
2021 - 2026 Genetic analysis of nuage formation regulated by non-domain type proteins
2024 - 2025 強毒性ウィルスとヒトタンパク質間相互作用のデータベースを安全・迅速に構築する
2021 - 2024 Tudorドメイン蛋白質群が関与するpiRNA生合成とヌアージュ形成機構の解明

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Papers (46)：

Toshie Kai, Jinglan Zheng, Taichiro Iki. Paralog-Dependent Specialization of Paf1C Subunit, Ctr9, for Sex Chromosome Gene Regulation and Male Germline Differentiation in Drosophila. Genes to Cells. 2025
Ritsuko Suyama, Toshie Kai. piRNA processing within non-membrane structures is governed by constituent proteins and their functional motifs. The FEBS Journal. 2025
Masaya Matsui, Shinichi Kawaguchi, Toshie Kai. Transcriptional Repression of reaper by Stand Still Safeguards Female Germline Development in Drosophila. 2025
Shinichi Kawaguchi, Wakana Isshiki, Toshie Kai. Factories without walls: The molecular architecture and functions of non-membrane organelles in small RNA-guided genome protection. Biochimica et biophysica acta. General subjects. 2025. 1869. 7. 130811-130811
Shinichi Kawaguchi, Xu Xin, Soga Takashi, Yamaguchi Kenta, Kawasaki Ryuuya, Shimouchi Ryota, Date Susumu, Kai Toshie. In silico screening by AlphaFold2 program revealed the potential binding partners of nuage-localizing proteins and piRNA-related proteins. eLife. 2025

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MISC (4)：

須山律子, 甲斐歳惠. Non-membranous RNP condensates control the fate of germline cells. 実験医学. 2021. 39. 10
Amit Anand, Teo Yee Wei, Katsutomo Okamura, Toshie Kai. HP1a functions to suppress the evolutionarily fixed and telomeric transposons via piRNAs. GENES & GENETIC SYSTEMS. 2016. 91. 6. 331-331
Amit Anand, Toshie Kai. Antisense piRNA amplification, but not piRNA production or nuage assembly, requires the Tudor-domain protein Qin Response. EMBO JOURNAL. 2014. 33. 6. 540-541
Ai Khim Lim, Liheng Tao, Toshie Kai. Post-transcriptional retroelement surveillance is mediated by piRNAs in Drosophila germline. MECHANISMS OF DEVELOPMENT. 2009. 126. S51-S51

Lectures and oral presentations (22)：

The Gender Landscape in Academia in Japan and Beyond
(JSPS Symposium on Promoting Gender Equality 2025)
キャリアパス委員会主催ランチタイムセミナー2024
(第47回分子生物学会年会 2024)
Processing of small RNAs safeguarding the germline genome in the non-membrane structure, nuage
([From Innovations to Applications] 20th Anniversary of relations Osaka U- Strasbourg U 2024)
グローバル研究時代の人生とキャリアの調和
(日本生化学会第64回生命科学夏の学校 2024)
キャリアパス委員会主催ランチタイムセミナー2023
(第46回分子生物学会年会 2023)

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Education (1)：

Professional career (1)：

Work history (10)：

2025/04 - 現在 The University of Osaka
2015/10 - 現在 Osaka University Graduate School of Frontier Biosciences Professor
2021/04 - 2024/03 Osaka University Center for Global Initiatives Director of Student Mobility Unit
2011/01 - 2015/09 The National University of Singapore Department of Biological Science Adjunct Associate Professor
2010/10 - 2015/09 Temasek Lifesciences Laboratory Senior Principal Investigator

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Committee career (4)：

Awards (1)：

Association Membership(s) (3)：

日本発生生物学会 , 日本分子生物学会 , 日本RNA学会

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