Research field (4)：
Structural biochemistry
, Chemical biology
, Biophysics
, Quantum beam science
Research keywords (6)：
放射光構造生物学
, 構造生物学
, X線結晶構造解析
, Protein Structure
, X-ray Crystallography
, Synchrotron Radiation
Research theme for competitive and other funds (6)：
2016 - 2019 Modification of polyketide synthase and elucidation of enzyme reaction which is difficult in chemical synthesis, and creation of novel natural products
2013 - 2016 Development of novel anti-cancer agents targeting de novo pyrimidine biosynthetic pathway
2012 - 2016 Construction of a biosynthetic logic toward a new era of natural product
2011 - 2012 Elucidation of succinyl transferase reaction mechanisms which is difficult to perform by organic synthesis
2005 - 2009 Chemical proteomics to reveal interaction between chemicals and proteins at angstrom level
2005 - 2006 Four Dimensional Structural Analysis of Biological Ion Pumps
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Papers (19)：
Hideo Okumura, Naoki Sakai, Hironori Murakami, Nobuhiro Mizuno, Yuki Nakamura, Go Ueno, Takuya Masunaga, Takashi Kawamura, Seiki Baba, Kazuya Hasegawa, et al. In situ crystal data-collection and ligand-screening system at SPring-8. Acta crystallographica. Section F, Structural biology communications. 2022. 78. Pt 6. 241-251
Nobutaka Numoto, Seiko Onoda, Yoshiaki Kawano, Hideo Okumura, Seiki Baba, Yoshihiro Fukumori, Kunio Miki, Nobutoshi Ito. Structures of oxygen dissociation intermediates of 400 kDa V2 hemoglobin provide coarse snapshots of the protein allostery. Biophysics and Physicobiology. 2022. 19. n/a-n/a
Nobutaka Numoto, Yoshiaki Kawano, Hideo Okumura, Seiki Baba, Yoshihiro Fukumori, Kunio Miki, Nobutoshi Ito. Coarse snapshots of oxygen-dissociation intermediates of a giant hemoglobin elucidated by determining the oxygen saturation in individual subunits in the crystalline state. IUCrJ. 2021. 8. Pt 6. 954-962
Yusuke Ohnishi, Norifumi Muraki, Daiki Kiyota, Hideo Okumura, Seiki Baba, Yoshiaki Kawano, Takashi Kumasaka, Hideaki Tanaka, Genji Kurisu. X-ray dose-dependent structural changes of the [2Fe-2S] ferredoxin from Chlamydomonas reinhardtii. Journal of biochemistry. 2020. 167. 6. 549-555
Seiki Baba, Nobuhiro Mizuno, Hideo Okumura, Nipawan Nuemket, Kazuya Hasegawa, Yuki Nakamura, Hironori Murakami, Go Ueno, Tomoki Fukui, Takaki Irie, et al. Upgrade of bending magnet MX beamline BL38B1 at SPring-8. 13TH INTERNATIONAL CONFERENCE ON SYNCHROTRON RADIATION INSTRUMENTATION (SRI2018). 2019. 2054
Kanoh Naoki, Kumashiro Saori, Simizu Siro, Osada Hiroyuki, Kondoh Yasumitsu, Hatakeyama Satoru, Tashiro Hideo. 49(P-13) Functional Group Independently Immobilized Arrays of Small Molecules : Proof of Concept. Symposium on the Chemistry of Natural Products, symposium papers. 2003. 45. 0. 287-292
Education (2)：
1998 - 2003 名古屋大学大学院 理学研究科 物質理学専攻
1994 - 1998 Nagoya University School of Science Department of Physics
Professional career (1)：
博士(理学) (名古屋大学)
Work history (5)：
2011/04 - 現在 Japan Synchrotron Radiation Research Institute
2010/04 - 2011/04 RIKEN
2007/04 - 2010/03 RIKEN
2005/07 - 2007/03 RIKEN
2003/04 - 2005/06 名古屋大学大学院 理学研究科 産学官連携研究員
Association Membership(s) (6)：
PROTEIN SCIENCE SOCIETY OF JAPAN
, THE BIOPHYSICAL SOCIETY OF JAPAN
, THE CRYSTALLOGRAPHIC SOCIETY OF JAPAN
, JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY
, THE JAPANESE SOCIETY FOR SYNCHROTRON RADIATION RESEARCH
, 日本ケミカルバイオロジー学会
