Goto Hiroaki

Affiliation and department：
Job title： Hospital Director/Head of Clinical Research Institute

Research field (2)： Fetal medicine/Pediatrics , Hematology and oncology

Research keywords (2)： Patient-derived Tumor Model , Childhood Cancer

Research theme for competitive and other funds (6)：

2024 - 2027 Tumor growth suppression based on the comprehensive understanding of the ubiquitin/proteasome system in pediatric rare neoplasms
2022 - 2025 Pathological analysis of malignant rhabdoid tumor by utilizing the human disease model library
2017 - 2020 Analysis for pathogenesis of drug-induced neurotoxicity by using pharmacogenomics and proteomics technique.
2015 - 2019 Development of highly precise diagnostic markers for pediatric neoplasms
2004 - 2005 急性リンパ性白血病における糖質コルチコイド感受性と細胞内グルタチオン酸濃度の関係

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Papers (234)：

Keisuke Kato, Hiroaki Goto, Mio Tanaka, Tetsuomi Suzuki, Yasunori Toyoda, Masato Shinkai, Norihiko Kitagawa, Toshiji Nishi, Hisato Kigasawa, Kenji Kurosawa, et al. Establishment and Characterization of a Novel Pleuropulmonary Blastoma Cell Line. Genes, Chromosomes and Cancer. 2024. 63. 10
Junko Yamanaka, Chitose Ogawa, Ayumu Arakawa, Takao Deguchi, Toshinori Hori, Nobutaka Kiyokawa, Hideaki Ueki, Masanori Nishi, Shinji Mochizuki, Takuro Nishikawa, et al. Outcomes in children with first-relapsed acute lymphoblastic leukemia in Japan: Results from JCCG Study JPLSG-ALL-R08. Pediatric blood & cancer. 2024. e31319
Hiroaki Goto, Akiko Kada, Chitose Ogawa, Ritsuo Nishiuchi, Junko Yamanaka, Akihiro Iguchi, Masanori Nishi, Kimiyoshi Sakaguchi, Tadashi Kumamoto, Shinji Mochizuki, et al. Treatment of relapsed acute lymphoblastic leukemia in children: an observational study of the Japan Children’s Cancer Group. International Journal of Hematology. 2024. 120. 5. 631-638
Keisuke Kato, Jun-Ichi Nagai, Hiroaki Goto, Masato Shinkai, Norihiko Kitagawa, Yasunori Toyoda, Toshiji Nishi, Hisato Kigasawa, Mio Tanaka, Kenji Kurosawa, et al. Establishment and characterization of a novel MDM2/MYCN-co-amplified neuroblastoma cell line, NBN-SHIM, established from a late recurrent stage MS tumor. Human cell. 2024
Atsushi Watanabe, Lu Wang, Tze King Tan, Kevin Y Urayama, Toshihiko Kizuki, Chiaki Komatsu, Keiko Kagami, Tamao Shinohara, Shin Kasai, Minori Tamai, et al. Acquired copy number amplification at the MYC enhancer in human B-precursor acute lymphoblastic leukemia cell lines. Cancer science. 2024

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MISC (92)：

小川千登世, 石原卓, 今井千速, 岡本康裕, 加藤元博, 康勝好, 後藤裕明, 堺田惠美子, 佐藤篤, 下之段秀美, et al. Consensus expert recommendations for optimal asparaginase use of ALL/LBL therapy in Japanese clinical practice. 月刊血液内科. 2024. 88. 4
児玉祐一, 西眞範, 佐藤篤, 今村知世, 出口隆生, 平川晃弘, 清河信敬, 大木健太郎, 嶋晴子, 加藤啓輔, et al. 小児再発・難治フィラデルフィア染色体陽性白血病に対するポナチニブ安全性確認試験. 日本血液学会学術集会. 2022. 84回. 1362-1362
玉井望雅, 玉井望雅, 笠井慎, グエンタオ, 加賀美恵子, 渡邊敦, 赤羽弘資, 矢ヶ崎英晃, 合井久美子, 三宅邦夫, et al. Associations of NR3C1 mutations and glucocorticoid resistance in BCP-ALL cell lines. 日本血液学会学術集会抄録(Web). 2021. 83rd
Akiko Hayashi, Eiko Ito, Motoko Omura, Noriko Aida, Mio Tanaka, Yukichi Tanaka, Hironobu Sato, Naoyuki Miyagawa, Tomoko Yokosuka, Fuminori Iwasaki, et al. Hypofractionated radiotherapy in children with diffuse intrinsic pontine glioma. Pediatrics international : official journal of the Japan Pediatric Society. 2020. 62. 1. 47-51
Takahiro Aoki, Hiroyuki Takahashi, Shiro Tanaka, Norio Shiba, Daiichiro Hasegawa, Shotaro Iwamoto, Kiminori Terui, Hiroshi Moritake, Hideki Nakayama, Akira Shimada, et al. Predisposition to Prolonged Neutropenia After Chemotherapy was Associated With Better Prognosis in Patients With Acute Myeloid Leukemia. PEDIATRIC BLOOD & CANCER. 2019. 66. S21-S21

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Education (1)：

1985 - 1991 Yokohama City University School of Medicine Medical Course

Professional career (1)：

医学博士 (横浜市立大学)

Work history (9)：

2012/04 - 現在 Kanagawa Children's Medical Center Division of Hematology/Oncology
2002/04 - 2012/03 Yokohama City University School of Medicine Department of Pediatrics
1999/07 - 2002/03 Childrens Hospital Los Angeles Division of Hematology-Oncology Research Fellow
1999/04 - 1999/06 St. Josef Hospital Department of Pediatrics
1998/04 - 1999/03 Yokohama Aiji Center Department of Pediatrics

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