Higashi-Kuwata Nobuyo

Affiliation and department：

Research field (1)： Virology

Research keywords (8)： Human hepatitis B virus , Human immunodeficiency virus , Cell biology , liver , Chronic hepatitis B , HIV infection , Drug development , Refractory Viral Infections

Research theme for competitive and other funds (9)：

2018 - 2021 Evaluation of cellular senescence associated with HBV infection and the effect of anti-HBV nucleic acid analog
2012 - 2012 Altered dynamics of HIVmCherry dissemination in huPBMC-transplanted NOJmice under anti-HIV drug administratio
2004 - 2006 肝再生時に星細胞が果たす役割の解明
2004 - 2005 Gene regulation by 3-D structure of extracellular matrix : a model for hepatic stellate cells
2003 - 2005 胆汁成分の新規処理機構の解明-胆道閉鎖症治療への応用を目指して-

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Papers (61)：

Masayuki Amano, Yasuko Ichikawa, Shota Matsumoto, Nobuyo Higashi-Kuwata, Yuki Takamatsu, Shuzo Matsushita, Shinya Shimada, Hiroaki Mitsuya. Neutralization activity of HCWs’ sera after Omicron XBB.1.5-adapted monovalent COVID-19 mRNA vaccination. Journal of Infection. 2024. 106179-106179
Arun K Ghosh, Monika Yadav, Satyanarayana Iddum, Somayeh Ghazi, Emma K Lendy, Uttara Jayashankar, Sydney N Beechboard, Yuki Takamatsu, Shin-Ichiro Hattori, Masayuki Aamano, et al. Exploration of P1 and P4 modifications of nirmatrelvir: Design, synthesis, biological evaluation, and X-ray structural studies of SARS-CoV-2 Mpro inhibitors. European journal of medicinal chemistry. 2024. 267. 116132-116132
Mari Shimura, Nobuyo Higashi-Kuwata, Asuka Fujiwara, Mai Taniguchi, Takayuki Ichinose, Fumie Hamano, Masaaki Uematsu, Takato Inoue, Satoshi Matsuyama, Takahiro Suzuki, et al. A lipid index for risk of hyperlipidemia caused by anti-retroviral drugs. Antiviral Research. 2024
Kazuhiro Haraguchi, Hiroki Kumamoto, Shuhei Imoto, Nobuyo Kuwata-Higashi, Hiroaki Mitsuya. Regio- and Stereoselective Synthesis of 2′-Deoxy-4′-thioguanine Nucleosides: Evaluation of Anti-Hepatitis B Virus Activity and Cytotoxicity Leading to Improved Selectivity Index by 4′-C-Cyanation. Synlett. 2023. 35. 06. 728-733
鍬田伸好, 辻耕平, 林宏典, 石井貴大, 小早川拓也, 中野堅太, 服部真一朗, 岸本直樹, 高宗暢暁, 青木宏美, et al. 抗SARS-CoV-2メインプロテアーゼ阻害剤の創薬研究開発. 日本エイズ学会誌. 2023. 25. 4. 428-428

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MISC (6)：

藤沼舞, 石綱遥, 三澤隆史, 出水庸介, 栗原正明, 満屋裕明, 鍬田伸好, 服部真一朗, 紺野奇重. 抗SARS-CoV-2剤創製へ向けた炭素環ヌクレオシドの核酸塩基部構造活性相関研究. 日本薬学会年会要旨集. 2022. 142年会. 28PO10-04S
Sanae Hayashi, Masanori Isogawa, Keigo Kawashima, Kyoko Ito, Natthaya Chuaypen, Nobuyo Higashi-Kuwata, Pisit Tangkijvanich, Hiroaki Mitsuya, Yasuhito Tanaka. A NOVEL DROPLET DIGITAL PCR REVEALS THE STABILITY OF INTRAHEPATIC HEPATITIS B VIRUS CCCDNA AND ITS CLINICAL APPLICATION. HEPATOLOGY. 2021. 74. 523A-524A
鍬田伸好, 青木学, Kulkarni Viraj, 服部真一朗, 青木宏美, 林宏典, 城野博史, 山川佑可子, 前田賢次, 刈谷龍昇, et al. 極めて強力な抗HIV活性を発揮する新規プロテアーゼ阻害剤GRL-142/KU-241の同定及びそのSIVmac251感染サルにおける抗ウイルス効果. 日本エイズ学会誌. 2018. 20. 4. 468-468
鍬田伸好, 青木学, 青木学, 青木学, 服部真一朗, 青木宏美, 青木宏美, 林宏典, 林宏典, 林宏典, et al. DRV耐性株を含む種々の多剤耐性変異株にも有効な新規抗HIV薬候補化合物KU-241の体内動態・脳組織内濃度・2週間反復投与毒性. 日本エイズ学会誌. 2016. 18. 4
林宏典, 青木学, DAS Debananda, 服部真一朗, 青木宏美, 鍬田伸好, 高松悠樹, RAVIKIRAN Yedidi, 長谷川和也, GHOSH Arun K, et al. KU-241が前例を見ない程強力な抗HIV作用を発揮する機序の解析. 日本エイズ学会誌. 2016. 18. 4

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