Fujiki Fumihiro

Affiliation and department：

Research field (2)： Immunology , Tumor diagnostics and therapeutics

Research keywords (3)：免疫記憶 , がん免疫療法 , 腫瘍免疫

Research theme for competitive and other funds (8)：

2021 - 2025 網羅的遺伝子ノックアウト技術を活用した新規がんー免疫チェックポイント標的薬の創製
2021 - 2021 Overcoming T cell exhaustion in chronic LCMV infection model and its application to cancer immunotherapy
2017 - 2020 Elucidation of molecular mechanism of T cell terminal differentiation lineage for cancer immunotherapy
2014 - 2017 A novel pathway regulating memory T cell development for cancer immunotherapy
2012 - 2014 Development of a novel cancer immunotherapy based on efficient induction of memory T cells.

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Papers (65)：

Masaki Ito, Shigeo Koido, Takeo Iwamoto, Soyoko Morimoto, Fumihiro Fujiki, Haruo Sugiyama, Saki Matsumoto, Clara Effenberger, Kazuma Kiyotani, Kiyotaka Shiba. Enhancing the immunogenicity of Wilms tumor 1 epitope in mesothelioma cells with immunoproteasome inhibitors. PloS one. 2024. 19. 8. e0308330
Fumihiro Fujiki, Soyoko Morimoto, Yuya Nishida, Satoe Tanii, Nao Aoyama, Miki Inatome, Kento Inoue, Akiko Katsuhara, Hiroko Nakajima, Jun Nakata, et al. Establishment of a novel NFAT-GFP reporter platform useful for the functional avidity maturation of HLA class II-restricted TCRs. Cancer immunology, immunotherapy : CII. 2023. 72. 7. 2347-2356
Hikaru Minagawa, Yoshiko Hashii, Hiroko Nakajima, Fumihiro Fujiki, Soyoko Morimoto, Jun Nakata, Toshiro Shirakawa, Takane Katayama, Akihiro Tsuboi, Keiichi Ozono. Enhanced antitumor activity of a novel, oral, helper epitope-containing WT1 protein vaccine in a model of murine leukemia. BMC cancer. 2023. 23. 1. 167-167
Yusuke Oji, Naoki Kagawa, Hideyuki Arita, Norifumi Naka, Ken-ichiro Hamada, Hidetatsu Outani, Yasushi Shintani, Yoshito Takeda, Eiichi Morii, Kenzo Shimazu, et al. WT1 Trio Peptide-Based Cancer Vaccine for Rare Cancers Expressing Shared Target WT1. Cancers. 2023. 15. 2. 393-393
Natsuki Nakagawa, Yoshiko Hashii, Hisako Kayama, Ryu Okumura, Hiroko Nakajima, Hikaru Minagawa, Soyoko Morimoto, Fumihiro Fujiki, Jun Nakata, Toshiro Shirakawa, et al. An oral WT1 protein vaccine composed of WT1-anchored, genetically engineered Bifidobacterium longum allows for intestinal immunity in mice with acute myeloid leukemia. Cancer immunology, immunotherapy : CII. 2022

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MISC (53)：

藤木文博, 杉山治夫. T-cell intrinsic vitamin A metabolism regulates memory T-cell differentiation. 月刊臨床免疫・アレルギー科. 2023. 79. 6
森本創世子, 藤木文博, 西田純幸, 西田純幸, 永田暁教, 中田潤, 中島博子, 尾路祐介, 岡芳弘, 杉山治夫. GEM併用WT1ワクチン投与膵癌患者からのWT1₁₂₆特異的high avidity TCRの単離. 日本臨床免疫学会総会プログラム・抄録集. 2023. 51st
永田暁教, 藤木文博, 森本創世子, 中田潤, 西田純幸, 西田純幸, 中島博子, 橋井佳子, 橋井佳子, 坪井昭博, et al. TCF1レポーターマウスを活用した腫瘍局所と所属リンパ節に存在する癌抗原特異的CD8⁺ T細胞の分類と解析. 日本がん免疫学会総会プログラム・抄録集. 2023. 27th
橋井佳子, 橋井佳子, 細谷要介, 岡芳弘, 尾路祐介, 中島博子, 中田潤, 藤木文博, 森本創世子, SHOUQ Alzaaqi, et al. WT1蛋白を標的とした小児固形腫瘍に対するがん免疫療法:予後と免疫学的解析. 日本がん免疫学会総会プログラム・抄録集. 2022. 26th
藤木文博. 腫瘍免疫ビタミンA代謝シグナルはメモリーT細胞を軸とした癌免疫療法を開発するための標的となる. 日本臨床免疫学会総会プログラム・抄録集. 2021. 49回. 90-90

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Patents (2)：

Method For Modifying T Cell Population
Antigen-specific helper t-cell receptor genes

Work history (3)：

2023/02 - 現在 Emory University Dept. of Microbiology & Immunology Visiting Scholar
2022/04 - 2024/06 大阪大学大学院医学系研究科癌ワクチン療法学寄附講座寄附講座准教授
- 2022/03 Osaka University Graduate School of Medicine

Association Membership(s) (4)：

血液疾患免疫療法学会 , THE JAPAN SOCIETY FOR CLINICAL IMMUNOLOGY , THE JAPANESE SOCIETY FOR IMMUNOLOGY , 日本がん免疫学会

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