Chen I-Shan

チンイサン | Chen I-Shan

Affiliation and department：
Job title： Lecturer (full-time)

Research field (2)： Physiology , Pharmacology

Research theme for competitive and other funds (9)：

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Papers (14)：

Chang Liu, I-Shan Chen, Michihiro Tateyama, Yoshihiro Kubo. Structural determinants of the direct inhibition of GIRK channels by Sigma-1 receptor antagonist. The Journal of biological chemistry. 2024. 107219-107219
I-Shan Chen, Jumpei Yasuda, Takuya Notomi, Tomoe Y Nakamura. Licorice metabolite 18β-glycyrrhetinic acid activates G protein-gated inwardly rectifying K+ channels. British journal of pharmacology. 2024. 181. 3. 447-463
Sakiko Matsumura, Jumpei Yasuda, Takuya Notomi, Yoshihiro Suzuki, I-Shan Chen, Daichi Murakami, Muneki Hotomi, Tomoe Y Nakamura. Direct toxicity of cigarette smoke extract on cardiac function mediated by mitochondrial dysfunction in Sprague-Dawley rat ventricular myocytes and human induced pluripotent stem cell-derived cardiomyocytes. PloS one. 2024. 19. 1. e0295737
Ivan Gando, Manuel Becerra Flores, I-Shan Chen, Hua-Qian Yang, Tomoe Y Nakamura, Timothy J Cardozo, William A Coetzee. CL-705G: a novel chemical Kir6.2-specific KATP channel opener. Frontiers in pharmacology. 2023. 14. 1197257-1197257
I-Shan Chen, Jodene Eldstrom, David Fedida, Yoshihiro Kubo. A novel ion conducting route besides the central pore in an inherited mutant of G-protein-gated inwardly rectifying K+ channel. The Journal of physiology. 2022. 600. 3. 603-622

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MISC (7)：

陳以珊, 久保義弘. K+チャネルのしくみ GIRKチャネルの、小分子による新規機能調節機構. 心電図. 2020. 40. 2. 107-113
I-Shan Chen, Chang Liu, Michihiro Tateyama, Izhar Karbat, Motonari Uesugi, Eitan Reuveny, Yoshihiro Kubo. Inhibitory Mechanisms of G-protein-gated Inwardly Rectifying K+ Channel by Antihistamines. BIOPHYSICAL JOURNAL. 2020. 118. 3. 117A-117A
Atsushi Suzuki, Jun Ishii, Aya Yoshida, Naoya Yamguchi, Tatsushi Tanaka, Kohei Aoyama, Michihiro Tateyama, I-Shan Chen, Yoshihiro Kubo, Toru Kimura, et al. Homozygous loss-of-function mutation in the SLC26A7 gene coding a novel iodide transporter causes goitrous congenital hypothyroidism. HORMONE RESEARCH IN PAEDIATRICS. 2019. 91. 36-36
I-Shan Chen, Michihiro Tateyama, Yuko Fukata, Motonari Uesugi, Yoshihiro Kubo. Effects and Activation Mechanisms of Ivermectin on G-Protein-Gated Inwardly Rectifying Potassium Channels. BIOPHYSICAL JOURNAL. 2018. 114. 3. 301A-301A
古谷和春, 陳以珊, 倉智嘉久. m2ムスカリン性アセチルコリン受容体を介したシグナル伝達の新しい制御. 日本生理学雑誌. 2016. 78. 1. 24-25

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Education (3)：

2010 - 2014 Osaka University Graduate School of Medicine PhD
2007 - 2009 Kaohsiung Medical University Department of Pharmacology, School of Medicine, College of Medicine Master
2003 - 2007 Kaohsiung Medical University School of Pharmacy BS

Work history (4)：

2021/04 - 現在 Wakayama Medical University Department of Pharmacology, School of Medicine Lecturer (full-time)
2015/04 - 2021/03 The Graduate University for Advanced Studies Department of Physiological Sciences, School of Life Science Assistant Professor
2015/04 - 2021/03 National Institute for Physiological Sciences Division of Biophysics and Neurobiology Project Assistant Professor
2014/04 - 2015/03 Osaka University Department of Pharmacology, Graduate School of Medicine Postdoctoral Researcher

Awards (3)：

2024/03 - 日本生理学会第25回日本生理学会奨励賞
2024/02 - 和歌山県立医科大学令和5年度学術論文奨励賞
2018/03 - The Physiological Society of Japan 2018 Hiroshi and Aya Irisawa Memorial Promotion Award for Young Physiologists

Association Membership(s) (4)：

THE JAPAN NEUROSCIENCE SOCIETY , THE PHYSIOLOGICAL SOCIETY OF JAPAN , THE JAPANESE PHARMACOLOGICAL SOCIETY , Biophysical Society

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