Fukami Tatsuki

フカミタツキ | Fukami Tatsuki

Affiliation and department：

Research field (2)： Clinical pharmacy , Pharmaceuticals - health and biochemistry

Research keywords (4)： Drug metabolism , Drug-induced toxicity , non-P450 enzymes , Genetic polymorphisms

Research theme for competitive and other funds (12)：

2023 - 2026 Elucidation of the role of AADAC in protection against toxicity and biological homeostasis through regulation of iron concentration
2024 - 2025 加水分解酵素AADACのがん抑制メカニズムの解明
2023 - 2023 薬効の個人差および毒性回避を目指したnon-P450アルコール基含有化合物酸化酵素の基盤情報の構築
2019 - 2022 AADACの毒性学的および病理学的意義の解明
2019 - 2020 食薬相互作用を利用した医薬品副作用の軽減戦略の構築

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Papers (172)：

Takumi Nakano, Masataka Nakano, Tatsuki Fukami, Miki Nakajima. Cigarette smoking modulates m6A modification, affecting the induction of CYP1A1 mRNA by regulating human ARNT and AHRR in A549 cells. Toxicology Letters. 2025. 407. 41-49
Kiamu Kurosawa, Masataka Nakano, Itsuki Yokoseki, Mei Tomii, Yuichiro Higuchi, Shotaro Uehara, Nao Yoneda, Hiroshi Suemizu, Tatsuki Fukami, Miki Nakajima. Switch/sucrose non-fermentable complex interacts with constitutive androstane receptor to regulate drug-metabolizing enzymes and transporters in the liver. Drug Metabolism and Disposition. 2025
Rei Mitamura, Seiya Takemoto, Yuka Aoyama, Koki Morita, Yuichiro Higuchi, Shotaro Uehara, Nao Yoneda, Hiroshi Suemizu, Tatsuki Fukami, Masataka Nakano, et al. Human aldo-keto reductase (AKR) 1C1 and 1C2 act as coactivators of pregnane X receptor, a master regulator of drug-metabolizing and gluconeogenesis enzymes. Drug Metabolism and Pharmacokinetics. 2025
Soshi Shinohara, Seijo Uchijima, Keiya Hirosawa, Mai Nagaoka, Masataka Nakano, Miki Nakajima, Tatsuki Fukami. Arylacetamide deacetylase regulates hepatic iron homeostasis to protect against carbon tetrachloride-induced ferroptosis. Archives of toxicology. 2024. 98. 12. 4059-4075
Rei Sato, Tatsuki Fukami, Kazuya Shimomura, Yongjie Zhang, Masataka Nakano, Miki Nakajima. Characterization of human alcohol dehydrogenase 4 and aldehyde dehydrogenase 2 as enzymes involved in the formation of 5-carboxylpirfenidone, a major metabolite of pirfenidone. Drug metabolism and disposition: the biological fate of chemicals. 2024

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MISC (18)：

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Lectures and oral presentations (27)：

薬物誘導性肝障害における反応性代謝物生成とフェロトーシスの関係性
(第52回日本毒性学会学術年会 2025)
加水分解酵素AADACのフェロトーシス抑制を介した薬物誘導性肝障害に対する新規保護的機能の解明
(日本薬学会第145年会 2025)
創薬を支えるnon-P450酵素の基礎知識:機能的特徴と種差
(薬物動態談話会 2024年度1月例会 2025)
Effects of miR-222-3p-mediated downregulation of arylacetamide deacetylase on drug hydrolysis and lipid accumulation
(The 26th North American ISSX Meeting and 39th JSSX Meeting 2024)
Novel mechanism of drug-metabolizing hydrolases regulating the toxicity caused by reactive metabolites
(The 26th North American ISSX Meeting and 39th JSSX Meeting 2024)

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Education (3)：

2006 - 2008 Kanazawa University Graduate School of Natural Science and Technology Division of Life Sciences
2004 - 2006 Kanazawa University Graduate School of Natural Science and Technology
2000 - 2004 Kanazawa University Faculty of Pharmaceutical Sciences

Professional career (1)：

博士(薬学) (金沢大学)

Work history (4)：

2015/02 - 現在 Kanazawa University Faculty of Pharmaceutical Sciences Associate Professor
2016/03 - 2016/12 National Institute of Health National Cancer Institute Special Volunteer
2008/10 - 2015/01 Kanazawa University Faculty of Pharmaceutical Sciences Assistant Professor
2006/04 - 2008/09 日本学術振興会特別研究員(DC1)

Committee career (7)：

2024/02 - 現在 "Drug Metabolism and Pharmacokinetics" Associate Editor
2023/02 - 現在 "Biochemical Pharmacology" Editorial Advisory Board
2021/01 - 現在 "Xenobiotica" Editorial Board
2019/10 - 現在 "Drug Metabolism Reviews" Editorial Board
2017 - 現在日本薬物動態学会代議員

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Awards (2)：

2018/10 - 日本薬物動態学会奨励賞
2014/11 - 日本薬学会北陸支部会学術奨励賞

Association Membership(s) (4)：

International Society for the Study of Xenobiotics , THE JAPANESE SOCIETY OF TOXICOLOGY , THE JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS , THE PHARMACEUTICAL SOCIETY OF JAPAN

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