Irie Takashi

イリエタカシ | Irie Takashi

Affiliation and department：
Job title： Accociate Professor

Research field (1)： Virology

Research theme for competitive and other funds (15)：

2017 - 2019 Development of a Novel Retroviral Vaccine Targeting Glycan Fluctuations
2017 - 2018 新コンセプト「ワクチン+アジュバント」ハイブリッドウイルスベクターの開発
2016 - 2018 Elucidation of interactions between paramyxoviral infection and host innate immunity
2013 - 2015 Elucidation of mechanisms of innate immune stimulation and evasion by RNA viruses
2012 - 2014 Analysis of structure and function of viral proteins that suppress innate immunity

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Papers (49)：

Masaya Fukushi, Ryosuke Ohsawa, Yasushi Okinaka, Daisuke Oikawa, Tohru Kiyono, Masaya Moriwaki, Takashi Irie, Kosuke Oda, Yasuhiro Kamei, Fuminori Tokunaga, et al. Optineurin deficiency impairs autophagy to cause interferon beta overproduction and increased survival of mice following viral infection. PLOS ONE. 2023. 18. 6. e0287545-e0287545
Tamura, Tomokazu, Ito, Jumpei, Uriu, Keiya, Zahradnik, Jiri, Kida, Izumi, Anraku, Yuki, Nasser, Hesham, Shofa, Maya, Kosugi, Yusuke, Fujita, Shigeru, et al. Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants. NATURE COMMUNICATIONS. 2023. 14. 1
Saito, Akatsuki, Irie, Takashi, Suzuki, Rigel, Maemura, Tadashi, Nasser, Hesham, Uriu, Keiya, Kosugi, Yusuke, Shirakawa, Kotaro, Sadamasu, Kenji, Kimura, Izumi, et al. Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation. NATURE. 2022. 602. 7896. 300-+
Mlcochova, Petra, Kemp, Steven A., Dhar, Mahesh Shanker, Papa, Guido, Meng, Bo, Ferreira, Isabella A. T. M., Datir, Rawlings, Collier, Dami A., Albecka, Anna, Singh, Sujeet, et al. SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion. NATURE. 2021. 599. 7883. 114-+
Yoriyuki Konno, Izumi Kimura, Keiya Uriu, Masaya Fukushi, Takashi Irie, Yoshio Koyanagi, Daniel Sauter, Robert J Gifford, So Nakagawa, Kei Sato. SARS-CoV-2 ORF3b Is a Potent Interferon Antagonist Whose Activity Is Increased by a Naturally Occurring Elongation Variant. Cell reports. 2020. 32. 12. 108185-108185

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MISC (2)：

入江崇, 酒井宏治, 坂口剛正. ウイルスベクターワクチンの現状と展望. BIO Clinica. 2019. 34. 2. 223-227
Oda Kosuke, Ootake Rina, Matoba Yasuyuki, Irie Takashi, Sakaguchi Takemasa. 2P-068 Molecular mechanism of Sendai virus C protein to propagate the virus during the infection. 2015. 67. 191-191

Lectures and oral presentations (92)：

センダイウイルスの持続感染性獲得メカニズムの解明
(第69回日本ウイルス学会学術集会 2022)
Latest findings on virology of Sendai virus
(2022)
センダイウイルスを利用したSARS-CoV-2 S蛋白質の機能解析
(第68回日本ウイルス学会学術集会 2021)
A regulatory mechanism of low expression of mononegavirus L protein by intergenic trinucleotide sequence and its significance.
(2021)
センダイウイルス~基礎ウイルス学から応用へ~
(名古屋大学第96回創薬科学セミナー・GTRセミナー 2019)

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Awards (3)：

2009/10/25 - 日本ウイルス学会理事長日本ウイルス学会賞(杉浦奨励賞) エンベロープウイルスの粒子形成・出芽機構の解明
2008/08 - Travel grant for the 14th International Virology Congress Paramyxovirus Sendai virus C proteins are essential for maintenance of negative-sense RNA genome in virus particles
2005/06 - American Society for Microbiology American Society for Virology Postdoctoral Fellow Travel Grant Importance of sequences and host proteins for L-domain function in VSV recombinants

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