Makoto Nakashima

Affiliation and department：

Research field (1)： Molecular biology

Research keywords (4)：神経免疫 , エピジェネティクス , HTLV-1 , 血液悪性腫瘍

Research theme for competitive and other funds (6)：

2025 - 2028 ウイルス因子と宿主トランスクリプトームの融合による超高精度HTLV-1関連疾患発症予測法および革新的発症予防法の開発
2025 - 2028 HTLV-1関連脊髄症の自己免疫仮説の実証に基づく新規治療法開発
2025 - 2028 HAM脊髄の空間トランスクリプトーム解析による新規神経障害機構の解明と制御法開発
2024 - 2027 スーパーエンハンサー領域のゲノムループ構造形成によるCD30過剰発現機構の解析
2022 - 2024 CD30によるROS-DSBを介したゲノム不安定性とATL病態進展機構の解析

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Papers (37)：

Makoto Nakashima, Kaho Nagai, Naoki Takao, Natsumi Araya, Yuuta Kuze, Jun Mizuike, Shu Tosaka, Satoko Aratani, Naoko Yagishita, Erika Horibe, et al. Chromatin remodeling enhances MAP3K8 expression in HAM: a key pathogenesis for therapeutic intervention. Nature communications. 2025. 16. 1. 9874-9874
Kenzo Sakurai, Yumi Ashikawa, Yoichiro Imaoka, Kumi Ohshima, Fumiaki Sano, Ayako Arai, Naoko Yagishita, Natsumi Araya, Makoto Nakashima, Erika Horibe, et al. A Case of Adult T-Cell Leukemia Following Satralizumab Treatment for Neuromyelitis Optica Spectrum Disorder. Internal medicine (Tokyo, Japan). 2025
Natsumi Araya, Makoto Yamagishi, Makoto Nakashima, Naomi Asahara, Kazuhiro Kiyohara, Satoko Aratani, Naoko Yagishita, Erika Horibe, Izumi Ishizaki, Toshiki Watanabe, et al. Virus-induced RGMa expression drives neurodegeneration in HTLV-1-associated myelopathy. JCI insight. 2025. 10. 11
Masumichi Saito, Tomoo Sato, Hiroo Hasegawa, Kenichiro Tanabe, Hazuka Yoshida-Furihata, Erika Horibe, Ariella Coler-Reilly, Naomi Nojiri, Shunsuke Yamauchi, Makoto Nakashima, et al. Clonality analysis of HTLV-1-infected cells enhances prognostic precision in smoldering adult T-cell leukemia/lymphoma. Haematologica. 2025
Shigeo Fuji, Masahito Tokunaga, Atae Utsunomiya, Junya Makiyama, Youko Suehiro, Ki-Ryang Koh, Makoto Nakashima, Yoshihisa Yamano, Kaoru Uchimaru. Improving outcome prediction in indolent ATL by subdividing intermediate risk into low- and high-intermediate groups. Annals of hematology. 2025. 104. 4. 2429-2436

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MISC (43)：

Araya N, Yamagishi M, Nakashima M, Asahara N, Kiyohara K, Aratani S, Yagishita N, Sato T, Uchimaru K, Yamano Y. Virus-induced RGMa is a key mediator of Neuronal Damage and Therapeutic Target in HAM. HTLV conference 2024. 2024
Sugata K, Tan BJY, Takanori M, Hossain MB, Rajib SA, Reda O, Tokunaga M, Nomura T, Masuda T, Nakashima M, et al. Integrated single cell analysis of HTLV-1 specific CD8 T cells in peripheral blood and cerebrospinal fluid from HAM/TSP patients. HTLV conference 2024. 2024
Nakashima M, Nagai K, Takao N, Araya N, Kuze Y, Suzuki Y, Uchimaru K, Yamagishi M, Yamano Y. Integrated multi-omics analyses to explore a novel inflammatory-inducing factor in HAM/TSP. HTLV conference 2024. 2024
松原千哲, 松岡賢市, 近藤歌穂, 藤原加奈子, 寺尾俊紀, 植田裕子, 松村彰文, 守山喬史, 村上裕之, 近藤匠, et al. 臍帯血移植後にHTLV-1感染T細胞の多クローン性増殖を伴って発症した肺合併症に対しCCR4抗体が著効した一例. 日本血液学会学術集会抄録(Web). 2023. 85th
新谷奈津美, 山岸誠, 清原和裕, 浅原尚美, 中島誠, 荒谷聡子, 荒谷聡子, 八木下尚子, 内丸薫, 佐藤知雄, et al. Neuronal Cell Damage by HTLV-1 infected cell in Patients with HAM/TSP. 日本HTLV-1学会学術集会. 2023. 9th

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Professional career (1)：

博士(医科学)

Awards (1)：

2025/08 - 第37回日本神経免疫学会学術集会学会賞 HTLV-1関連脊髄症におけるクロマチン構造異常を介した炎症促進機序の解明と分子標的治療法の開発

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