Research field (1)：
Pharmaceuticals - health and biochemistry
Research theme for competitive and other funds (4)：
2022 - 2025 NLRP3インフラマソーム阻害作用を持つ天然物を活用した創薬研究への展開
2019 - 2022 Research on drug development utilizing natural products with both anti-NLRP3 inflammasome and anti-fibrosis properties
2015 - 2018 Search for the target molecule of the licorice component inhibiting NLRP3 inflammasome and development into drug discovery research
2005 - 2009 Enhancement of Th1 and antitumor immunity by Ag85B and Peptide-25.
Papers (13)：
Fumitake Usui-Kawanishi, Koudai Kani, Tadayoshi Karasawa, Hiroe Honda, Nobuyuki Takayama, Masafumi Takahashi, Kiyoshi Takatsu, Yoshinori Nagai. Isoliquiritigenin inhibits NLRP3 inflammasome activation with CAPS mutations by suppressing caspase-1 activation and mutated NLRP3 aggregation. Genes to cells : devoted to molecular & cellular mechanisms. 2024
Yuki Tada, Kaichi Kasai, Nana Makiuchi, Naoya Igarashi, Koudai Kani, Shun Takano, Hiroe Honda, Tsutomu Yanagibashi, Yasuharu Watanabe, Fumitake Usui-Kawanishi, et al. Roles of Macrophages in Advanced Liver Fibrosis, Identified Using a Newly Established Mouse Model of Diet-Induced Non-Alcoholic Steatohepatitis. International journal of molecular sciences. 2022. 23. 21
Riko Ishibashi, Yukihiro Furusawa, Hiroe Honda, Yasuharu Watanabe, Shiho Fujisaka, Miyu Nishikawa, Shinichi Ikushiro, Shin Kurihara, Yoshiaki Tabuchi, Kazuyuki Tobe, et al. Isoliquiritigenin Attenuates Adipose Tissue Inflammation and Metabolic Syndrome by Modifying Gut Bacteria Composition in Mice. Molecular Nutrition & Food Research. 2022. 66. 10. 2101119-2101119
Masaru Ogasawara, Shino Yamasaki-Yashiki, Masahiro Hamada, Tomomi Yamaguchi-Miyamoto, Toru Kawasuji, Hiroe Honda, Tsutomu Yanagibashi, Masashi Ikutani, Yasuharu Watanabe, Ryota Fujimoto, et al. Betulin Attenuates TGF-β1- and PGE<sub>2</sub>-Mediated Inhibition of NK Cell Activity to Suppress Tumor Progression and Metastasis in Mice. Biological and Pharmaceutical Bulletin. 2022. 45. 3. 339-353
Watanabe Y, Nagai Y, Honda H, Okamoto N, Yanagibashi T, Ogasawara M, Yamamoto S, Imamura R, Takasaki I, Hara H, et al. Bidirectional crosstalk between neutrophils and adipocytes promotes adipose tissue inflammation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019. 33. 11. 11821-11835
Hidemasa NAGAI, Hiroe HONDA, Masayuki HAYASHI, The Drug Formulation, Study Group, in Toyama, Pharmaceutical Research Association. Development of Design Space in Twin-screw Type Granulation. ANNUAL REPORT OF TOYAMA PREFECTURAL INSTITUTE FOR PHARMACEUTICAL RESEARCH. 2023. 50. 19-24
Takeharu MINAMITANI, Hiroe HONDA, Tsutomu YANAGIBASHI, Yasuharu WATANABE, Rieko KOJIMA, Yukihiko AIKAWA and the Biological Analysis Group in Toyama Pharmaceutical Research Association. Analysis of blood concentrations of antibody drugs using LC-MS/MS. ANNUAL REPORT OF TOYAMA PREFECTURAL INSTITUTE FOR PHARMACEUTICAL RESEARCH. 2023. 50. 25-32
Rieko KOJIMA, Hideo OGISO, Hiroe HONDA, Tomomi MIYAMOTO, The Biological Analysis Group in Toyama Pharmaceutical Research Association. Characterization and similarity comparison of biopharmaceuticals. ANNUAL REPORT OF TOYAMA PREFECTURAL INSTITUTE FOR PHARMACEUTICAL RESEARCH. 2022. 49. 25-34
MIYAMOTO T, MATSUNAGA T, HONDA H, YANAGIBASHI T, OGASAWARA M, TAKAYAMA N, AIKAWA Y, KAWASHIRI C, The Biological, Study Group, et al. Quality evaluation of biopharmaceuticals- Examination of Comparability of biosimilar -. 2019. 46. 24-27
