Rchr
J-GLOBAL ID:201801006775293078
Update date: Feb. 14, 2024
Takuji Ohyama
オオヤマ タクジ | Takuji Ohyama
Affiliation and department:
Job title:
Professor
Homepage URL (1):
https://takujioyama1970.wordpress.com/
Research field (1):
Structural biochemistry
Research keywords (3):
Nuclear receptor
, DNA replication and repair
, X-ray Crystallography
Research theme for competitive and other funds (1):
- 2006 - 2010 Structural basis of functional coupling between transcription and cellular metabolism
Papers (72):
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Akihiro Honda, Shotaro Kamata, Makoto Akahane, Yui Machida, Kie Uchii, Yui Shiiyama, Yuki Habu, Saeka Miyawaki, Chihiro Kaneko, Takuji Oyama, et al. Functional and Structural Insights into Human PPARα/δ/γ Subtype Selectivity of Bezafibrate, Fenofibric Acid, and Pemafibrate. 2022. 23. 9. 4726
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Zengwei Liao, Takuji Oyama, Yumi Kitagawa, Katsuo Katayanagi, Kosuke Morikawa, Masayuki Oda. Pivotal role of a conserved histidine in Escherichia coli ribonuclease HI as proposed by X-ray crystallography. Acta Crystallographica Section D Structural Biology. 2022. 78. 3. 390-398
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Takuji Oyama, Kazuki Takiguchi, Hiroyuki Miyachi. Crystal structures of the ligand-binding domain of human peroxisome proliferator-activated receptor δ in complexes with phenylpropanoic acid derivatives and a pyridine carboxylic acid derivative. Acta crystallographica. Section F, Structural biology communications. 2022. 78. Pt 2. 81-87
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Keisuke Oki, Mariko Nagata, Takeshi Yamagami, Tomoyuki Numata, Sonoko Ishino, Takuji Oyama, Yoshizumi Ishino. Family D DNA polymerase interacts with GINS to promote CMG-helicase in the archaeal replisome. NUCLEIC ACIDS RESEARCH. 2021. 50. 7. 3601-3615
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Oyama T, Kamata S, Ishii I, Miyachi H. Crystal structures of the human peroxisome proliferator-activated receptor (PPAR)α ligand-binding domain in complexes with a series of phenylpropanoic acid derivatives generated by a ligand-exchange soaking method. BIOLOGICAL & PHARMACEUTICAL BULLETIN. 2021. 44. 9. 1202-1209
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MISC (23):
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津中康央, 津中康央, 藤原芳江, 大山拓次, 広瀬進, 森川耿右. FACTを介したクロマチンリモデリングの分子機構. 日本生化学会大会(Web). 2016. 89回. [2P-276]
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津中康央, 津中康央, 藤原芳江, 大山拓次, 広瀬進, 森川耿右. FACTを介したクロマチンリモデリングの分子機構. 日本分子生物学会年会プログラム・要旨集(Web). 2016. 89回. [2P-276]
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大橋雅生, 蒲生佳奈恵, 田中雄大, 紅山容子, 脇稔, 松浦信康, 槇島誠, 大山拓次, 松野研司, 天田雅文, et al. 新規PPARγアンタゴニスト/インバースアゴニストの創製. 日本薬学会年会要旨集(CD-ROM). 2014. 134th
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尾木野弘実, 石野園子, 真柳浩太, 大山拓次, 白井剛, 森川耿右, HAUGLAND, Gyri Teien, BIRKELAND Nils-Kare, 神田大輔, et al. 好熱性アーキアThermoplasma acidophilum における複製ヘリカーゼの分岐進化した活性化メカニズム. 日本分子生物学会年会プログラム・要旨集(Web). 2013. 36th. 2P-0128 (WEB ONLY)
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大橋雅生, 大山拓次, 和久剛, 片岡健, 八代正和, 許南浩, 宮地弘幸. 水溶性向上を指向したα-ベンジルフェニルプロピオン酸型PPARγ選択的パーシャルアゴニストの創製. メディシナルケミストリーシンポジウム講演要旨集. 2012. 30th. 73
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Books (1):
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Glutame receptors and synpse associated proteins
日本結晶学会誌 2014
Lectures and oral presentations (5):
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Toward high-throughput crystal structure determination of PPAR ligand-binding domain in complex with insoluble ligands
(Symposium in the 142th Annual Meeting of the Parmaceutical Society of Japan 2022)
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プレスリリース:アーキア(古細菌)のDNA合成酵素が鋳型DNAの二本鎖を解く機能に貢献!〜アーキア(古細菌)がどのように DNA を複製するのかを解明〜
(2021)
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Crystal structure of the PPAR delta binding domain in complex with the partial agonist JK122
(The Regular Meeting of The Japanese Biochemical Society, Kanto Branch 2013)
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Crystal structure of the cytoplasmic dynein motor domain
(Annual Meeting of the Crystallographic Society of Japan 2011 2011)
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Molecular mechanism of DNA replication and repair based on three-dimensional structure: focusing on the clamp-loading complex
(Symposium in the 6th Annual Meeting of Protein Science Socity of Japan 2006)
Professional career (1):
Work history (8):
- 2015/04/01 - Faculty of Life and Environmental Sciences, University of Yamanashi Associate Professor
- 2012/04/01 - 2015/03/31 Faculty of Life and Environmental Sciences, University of Yamanashi Department of Biotechnology Assitant Professor
- 2011/04/01 - Institute for Protein Research, Osaka University Laboratory of Protein Crystallography Specially Appointed Researcher
- 2008/10/01 - 2011/03/31 Institute for Protein Research, Osaka University Laboratory of Protein Organic Chemistry Specially Appointed Researcher
- 2005/10/01 - 2008/09/30 Institute for Protein Research, Osaka University Biomolecular Recognition (Takara-Bio) Endowed Division Assitant Professor
- 2005/04/01 - 2005/09/30 Biomolecular Engineering Research Institute Department of Structural Biology Senior Researcher
- 2001/04/01 - 2005/03/31 Biomolecular Engineering Research Institute Department of Structural Biology Researcher
- 1999/04/01 - 2001/03/31 Biomolecular Engineering Research Institute Department of Structural Biology Post Doctral Fellow
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Committee career (1):
- 2016/08/01 - 2018/07/31 独立行政法人日本学術振興会 特別研究員等審査会専門委員、卓越研究員候補者選考委員会書面審査員及び国際事業委員会書面審査員・書面評価員
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