Research theme for competitive and other funds (3)：
2013 - 2016 新規選択的エストロゲン受容体モジュレーターによる子宮筋腫治療薬開発
2011 - 2013 Uterine leiomyoma and AMPK/mTOR signal transduction pathway- a new therapeutic strategy.
2010 - 2011 子宮筋腫細胞増殖・線維化における、低酸素細胞内シグナル伝達機構解析
Papers (34)：
Eiji Hishinuma, Muneaki Shimada, Naomi Matsukawa, Yoshiko Shima, Bin Li, Ikuko N. Motoike, Yusuke Shibuya, Tatsuya Hagihara, Shogo Shigeta, Hideki Tokunaga, et al. Identification of predictive biomarkers for endometrial cancer diagnosis and treatment response monitoring using plasma metabolome profiling. Cancer & Metabolism. 2023. 11. 1
Eiji Hishinuma, Muneaki Shimada, Naomi Matsukawa, Bin Li, Ikuko N Motoike, Tatsuya Hagihara, Shogo Shigeta, Hideki Tokunaga, Daisuke Saigusa, Kengo Kinoshita, et al. Identification of predictive biomarkers for diagnosis and radiation sensitivity of uterine cervical cancer using wide-targeted metabolomics. The journal of obstetrics and gynaecology research. 2023. 49. 8. 2109-2117
Eiji Hishinuma, Muneaki Shimada, Naomi Matsukawa, Bin Li, Ikuko N. Motoike, Tatsuya Hagihara, Shogo Shigeta, Hideki Tokunaga, Daisuke Saigusa, Kengo Kinoshita, et al. Identification of predictive biomarkers for diagnosis and radiation sensitivity of uterine cervical cancer using wide-targeted metabolomics. Journal of Obstetrics and Gynaecology Research. 2023
Takamichi Minato, Shin Ito, Bin Li, Haruna Fujimori, Mai Mochizuki, Kazunori Yamaguchi, Keiichi Tamai, Muneaki Shimada, Hideki Tokunaga, Shogo Shigeta, et al. Liquid biopsy with droplet digital PCR targeted to specific mutations in plasma cell-free tumor DNA can detect ovarian cancer recurrence earlier than CA125. Gynecologic Oncology Reports. 2021. 38. 100847-100847
Eiji Hishinuma, Muneaki Shimada, Naomi Matsukawa, Daisuke Saigusa, Bin Li, Kei Kudo, Keita Tsuji, Shogo Shigeta, Hideki Tokunaga, Kazuki Kumada, et al. Wide-Targeted Metabolome Analysis Identifies Potential Biomarkers for Prognosis Prediction of Epithelial Ovarian Cancer. Toxins. 2021. 13. 7
Yusuke Shibuya, Hideki Tokunaga, Bin Li, Jun Yasuda, Nobuo Yaegashi. Identification of Somatic Genetic Alterations in Ovarian Clear Cell Carcinoma with Next Generation Sequencing. REPRODUCTIVE SCIENCES. 2018. 25. 92A-92A
Establishment and management a clinical biobank
(2023)
Establishment and management a clinical biobank
(2022)
Clinical biobank
(2022)
Clinical Biobank in INGEM
(Collaborative Seminar by Tohoku University and CEA, France Toward the Next Generation Medicine 2018)
Investigate the Inhibitory Effect of SS5020-A Selective Estrogen Receptor Modulator on UterineLeiomyomas
(63rd Society for Reproductive Investigation 2016)
