Masatoshi Ohga

オオガマサトシ | Masatoshi Ohga

Affiliation and department：
Job title： Lecturer

Research field (3)： Animals: biochemistry, physiology, behavioral science , Laboratory animal science , Zoological sciences

Research keywords (2)： Round spermatid injection (ROSI) , 個体形成能

Research theme for competitive and other funds (14)：

2023 - 2027 Improving Developmental Potential of ROSI-derived Zygotes via Elimination of Inherited Epigenome from Round Spermatids
2024 - 2026 受精卵の代謝による発生制御とその応用を目指して
2024 - 2025 マウス1細胞期胚におけるセリン代謝による発生制御機構とその機能の解明
2023 - 2025 マウス円形精子細胞注入胚のエピゲノム改変による出産成績改善の試み
2023 - 2024 着床前初期胚発生期に生じた代謝記憶の次世代への継承

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Papers (32)：

Masatoshi Ooga. Chromatin structure in totipotent mouse early preimplantation embryos. The Journal of reproduction and development. 2024
Yasuyuki Kikuchi, Daiyu Ito, Sayaka Wakayama, Masatoshi Ooga, Teruhiko Wakayama. Time-lapse observation of mouse preimplantation embryos using a simple closed glass capillary method. Scientific reports. 2023. 13. 1. 19893-19893
Masatoshi Ooga, Yasuyuki Kikuchi, Daiyu Ito, Kousuke Kazama, Rei Inoue, Mizuki Sakamoto, Sayaka Wakayama, Teruhiko Wakayama. Aberrant histone methylation in mouse early preimplantation embryos derived from round spermatid injection. Biochemical and Biophysical Research Communications. 2023
Li Ly Yang, Daiyu Ito, Natsuki Ushigome, Sayaka Wakayama, Masatoshi Ooga, Teruhiko Wakayama. A novel, simplified method to prepare and preserve freeze-dried mouse sperm in plastic microtubes. The Journal of reproduction and development. 2023. 69. 4. 198-205
Akihiko Sakashita, Masatoshi Ooga, Kai Otsuka, So Maezawa, Chikara Takeuchi, Sayaka Wakayama, Teruhiko Wakayama, Satoshi H Namekawa. Polycomb protein SCML2 mediates paternal epigenetic inheritance through sperm chromatin. Nucleic Acids Research. 2023

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MISC (28)：

ITO Daiyu, WAKAYAMA Sayaka, EMURA Rina, OOGA Masatoshi, WAKAYAMA Teruhiko. Mouse offspring obtained from freeze dried spermatozoa after transportation via postcard. The Journal of Reproduction and Development Supplement. 2021. 114. OR-43-OR-43
EMURA Rina, WAKAYAMA Sayaka, ITO Daiyu, OOGA Masatoshi, WAKAYAMA Teruhiko. Effect of sperm pre-incubation period on the quality of freeze-dried spermatozoa. The Journal of Reproduction and Development Supplement. 2021. 114. P-86-P-86
USHIGOME Natsuki, WAKAYAMA Sayaka, ITO Daiyu, OOGA Masatoshi, WAKAYAMA Teruhiko. Production of offspring from non-frozen vacuum dried spermatozoa. The Journal of Reproduction and Development Supplement. 2021. 114. P-87-P-87
INOUE Rei, KIKUCHI Yasuyuki, WAKAYAMA Sayaka, WAKAYAMA Teruhiko, OOGA Masatoshi. Evaluation of the developmental potential of early mouse preimplantation embryos using chromatin looseness measured by live imaging. The Journal of Reproduction and Development Supplement. 2021. 114. P-47-P-47
YANG Li, ITO Daiyu, OOGA Masatoshi, WAKAYAMA Sayaka, WAKAYAMA Teruhiko. A novel and economic mothod for sperm freeze-drying using 1.5mL microcentrifuge tubes. The Journal of Reproduction and Development Supplement. 2021. 114. P-24-P-24

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Lectures and oral presentations (8)：

円形精子細胞由来雄性前核に異常なヒストン修飾を引き起こすヒストン変異体の探索
(日本生殖発生医学会第15回学術集会 2020)
マウス1細胞期胚のクロマチン構造の"緩み"におけるParental asymmetryの形成機構について
(日本生殖発生医学会第15回学術集会 2020)
マウスROSI胚の雄性前核におけるエピジェネティックな異常とTSA処理が及ぼす影響
(日本生殖発生医学会第15回学術集会 2020)
Mechanisms of the establishment for parental asymmetric chromatin structure in mouse zygotes
(The second international conference on cell reprogramming and reproductive biotechnology 2019)
Identification and correction of epigenetic abnormalities in male pronuclei of mouse ROSI-zygote
(The second international conference on cell reprogrammingand reproductive biotechnology 2019)

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Education (3)：

2009 - 2012 東京大学 Graduate school of frontier sciences Department of integrated bioscience
2005 - 2007 The University of Tokyo Graduate School of Frontier Sciences
2001 - 2005 Meiji University School of Agriculture Department of Agricultural Chemistry

Professional career (1)：

Work history (8)：

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Awards (6)：

2023/09 - Society of Reproduction and Development Study of Chromatin Structure in Mouse Zygotes
2020/03 - 日本生殖発生医学会学術奨励賞マウス1細胞期胚のクロマチン構造の"緩み”におけるParental asymmetryの形成機構について
2016/09 - 日本繁殖生物学会 Journal of Reproduction and Development Outstanding Paper Award 2015 Japan
2016/02 - 第一回核移植研究会 John Gurdon Poster Award Involvement of Chd9 in loosened chromatin structure in growing oocytes
2014/08 - 日本繁殖生物学会優秀発表賞(口頭発表部門 ) Analysis of chromatin structure in mouse preimplantation embryos by fluorescent recovery after photobleaching (FRAP)

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Association Membership(s) (1)：

日本繁殖生物学会

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