Kujirai Tomoya

Affiliation and department：

Research field (1)： Genetics

Research keywords (7)： Biochemistry , Cryo-EM , X-ray crystallography , Transcription , Gene regulation , Nucleosome , Chromatin

Research theme for competitive and other funds (7)：

2022 - 2025 クロマチン構造における自然免疫制御機構の解明
2020 - 2025 Structural basis of higher-order complexes connecting transcription and its related functions
2020 - 2025 転写と共役したヌクレオソーム再構築の分子メカニズムの解明
2020 - 2024 RNAポリメラーゼを中心に形成される中核的複合体の構造基盤
2020 - 2022 Elucidation of recognition and regulation of chromatin by innate immune DNA sensor cGAS

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Papers (50)：

Takayuki Hoshii, Sota Kikuchi, Tomoya Kujirai, Takeshi Masuda, Tomoko Ito, Satoshi Yasuda, Makoto Matsumoto, Bahityar Rahmutulla, Masaki Fukuyo, Takeshi Murata, et al. BOD1L mediates chromatin binding and non-canonical function of H3K4 methyltransferase SETD1A. Nucleic acids research. 2024
Tomoaki Kimura, Seiya Hirai, Tomoya Kujirai, Risa Fujita, Mitsuo Ogasawara, Haruhiko Ehara, Shun-Ichi Sekine, Yoshimasa Takizawa, Hitoshi Kurumizaka. Cryo-EM structure and biochemical analyses of the nucleosome containing the cancer-associated histone H3 mutation E97K. Genes to cells : devoted to molecular & cellular mechanisms. 2024
Yuki Yamanashi, Shinpei Takamaru, Atsushi Okabe, Satoshi Kaito, Yuto Azumaya, Yugo Kamimura, Kenzo Yamatsugu, Tomoya Kujirai, Hitoshi Kurumizaka, Atsushi Iwama, et al. Chemical catalyst manipulating cancer epigenome and transcription. 2024
Tamiko Nozaki, Mayu Onoda, Misuzu Habazaki, Yuma Takeuchi, Hisashi Ishida, Yuko Sato, Tomoya Kujirai, Kayo Hanada, Kenzo Yamatsugu, Hitoshi Kurumizaka, et al. Logics for Developing Regioselective Histone Acetylating Catalysts. 2024
Naoki Goto, Kazuma Suke, Nao Yonezawa, Hidenori Nishihara, Tetsuya Handa, Yuko Sato, Tomoya Kujirai, Hitoshi Kurumizaka, Kazuo Yamagata, Hiroshi Kimura. ISWI chromatin remodeling complexes recruit NSD2 and H3K36me2 in pericentromeric heterochromatin. Journal of Cell Biology. 2024. 223. 8

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MISC (4)：

越後谷健太, 越後谷健太, 鯨井智也, 滝沢由政, 増本博司, 胡桃坂仁志, 胡桃坂仁志. Biochemical and structural analyses of the chromatin regulation by DEK. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
鯨井智也, 滝沢由政, 胡桃坂仁志. 【イメージング時代の構造生命科学細胞の動態、膜のないオルガネラ、分子の構造変化をトランススケールに観る】(第1章)近年の技術革新と解かれた構造クライオ電子顕微鏡によるクロマチンダイナミクス研究. 実験医学. 2020. 38. 5. 692-696
鯨井智也, ZIERHUT Christian, 滝沢由政, KIM Ryan, 根岸瑠美, 粉間信樹, 粉間信樹, 平井誠也, 平井誠也, 船引宏則, et al. cGAS-ヌクレオソーム複合体構造から明らかになったヌクレオソームによるcGAS不活性化のメカニズム. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
NEGISHI Lumi, TANAKA Hiroki, HIRANO Rina, KUJIRAI Tomoya, KURUMIZAKA Hitoshi. Identification of proteins that interact with nucleosomes by Quantitative Proteomics. 生物物理(Web). 2019. 59. Supplement 1-2

Professional career (1)：

博士(理学) (早稲田大学)

Work history (4)：

2018/04 - 現在 The University of Tokyo Institute for Quantitative Biosciences Research Associate
2015/04 - 2018/03 Waseda University Graduate School of Advanced Science and Engineering, Department of Electrical Engineering and Bioscience Doctoral course
2013/04 - 2015/03 Waseda University Graduate School of Advanced Science and Engineering, Department of Electrical Engineering and Bioscience Master course
2009/04 - 2013/03 Waseda University Faculty of Advanced Science and Engineering, Department of Electrical Engineering and Bioscience

Awards (5)：

2022/04 - The Minister of Education, Culture, Sports, Science and Technology The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology The Young Scientists’ Award
2019/09 - The Japanese Biochemical Society Young Investigator Award
2019/05 - The Japanese Society for Epigenetics JSE young investigator award
2018/09 - The Japanese Biochemical Society JB Award
2016/09 - 第89回日本生化学会大会若手優秀発表賞

Association Membership(s) (4)：

THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE CRYSTALLOGRAPHIC SOCIETY OF JAPAN , THE JAPANESE SOCIETY FOR EPIGENETICS , THE JAPANESE BIOCHEMICAL SOCIETY

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