Naohiko Koshikawa

コシカワナオヒコ | Naohiko Koshikawa

Affiliation and department：
Job title：教授

Research field (4)： Experimental pathology , Pathobiochemistry , Tumor diagnostics and therapeutics , Tumor biology

Research keywords (8)： Carcinogenesis , 生活習慣病 , Reverse phase protein array (RPPA) , Clinical cancer diagnostics and therapeutics , cancer invasion and metastasis , Proteolysis , Extracellular matrix (ECM) , Matrix metalloproteinases (MMPs)

Research theme for competitive and other funds (20)：

2021 - 2024 新規ラミニン融合遺伝子による扁平上皮癌の集団浸潤の分子機序の解明
2022 - 2023 Integrated analysis and regulation of cellular diversity
2017 - 2022 Integrated analysis and regulation of cellular diversity
2017 - 2022 Analysis of the molecular mechanism for formation and breakdown of biotissues by mathematical modeling
2020 - 2022 Liquid biopsyによる腫瘍特異的蛋白質分解断片をバイオマーカーとした早期膵癌診断法の開発

Show all

Papers (123)：

Shinya Sato, Masatoshi Nakagawa, Takeshi Terashima, Soichiro Morinaga, Yohei Miyagi, Eisaku Yoshida, Toru Yoshimura, Motoharu Seiki, Shuichi Kaneko, Makoto Ueno, et al. EphA2 Proteolytic Fragment as a Sensitive Diagnostic Biomarker for Very Early-stage Pancreatic Ductal Carcinoma. Cancer research communications. 2023. 3. 9. 1862-1874
Kazuki Ikeda, Ryo Kaneko, Eiki Tsukamoto, Nobuaki Funahashi, Naohiko Koshikawa. Proteolytic cleavage of membrane proteins by membrane type-1 MMP regulates cancer malignant progression. Cancer science. 2023. 114. 2. 348-356
Mitsuyuki Koizumi, Shinya Sato, Mitsuyo Yoshihara, Yoshiyasu Nakamura, Hideyuki Terao, Yoichiro Okubo, Kota Washimi, Emi Yoshioka, Tomoyuki Yokose, Takeshi Kishida, et al. Chronological Change in EPHA2 Protein Expression Is Associated With Recurrence of Bladder Cancer. Anticancer research. 2022. 42. 12. 5783-5794
Takashi Karashima, Susumu Umemoto, Takeshi Kishida, Kimito Osaka, Masatoshi Nakagawa, Eisaku Yoshida, Toru Yoshimura, Masahiko Sakaguchi, Hiroyuki Nishimoto, Mami Tai, et al. Clinical evaluation of urine laminin-γ2 monomer as a potent biomarker for non-muscle invasive bladder cancer. Cancer Medicine. 2022. 12. 3. 2453-2462
Mizuki Yamamoto, Jin Gohda, Ayako Kobayashi, Keiko Tomita, Youko Hirayama, Naohiko Koshikawa, Motoharu Seiki, Kentaro Semba, Tetsu Akiyama, Yasushi Kawaguchi, et al. Metalloproteinase-Dependent and TMPRSS2-Independent Cell Surface Entry Pathway of SARS-CoV-2 Requires the Furin Cleavage Site and the S2 Domain of Spike Protein. mBio. 2022. 13. 4. e0051922

ｍore...

MISC (37)：

兼子崚, 舟橋伸昭, 吉村徹, 山下太郎, 越川直彦. ラミニンγ2単鎖をバイオマーカーとした肝発がん,遠隔転移の予測を可能とする新たな診断法. 電気泳動. 2023. 67. 2. 59-64
室井敦, 榎本将士, 森竜樹, 石渡道徳, 星野大輔, 鈴木貴, 越川直彦. 組織・臓器の構築と制御の統合的理解を目指した細胞ダイバーシティー研究数理モデルを用いたがんの悪性化進展制御の解明. 日本生化学会大会プログラム・講演要旨集. 2019. 92回. [2S12a-06]
Tatsuki Mori, Masashi Enomoto, Atsushi Muroi, Naohiko Koshikawa, Takashi Suzuki. Modeling of tumor progression signaling pathway via EphA2 and EGFR. CANCER SCIENCE. 2018. 109. 860-860
青木光希子, 古賀佳織, 宮崎健, 濱崎慎, 越川直彦, 尾山大明, 秦裕子, 鍋島一樹. CD73はEmmprinと複合体を形成し線維芽細胞からのMMP-2産生に関与する. 日本結合組織学会学術大会プログラム・抄録集. 2017. 49回. 120-120
Hirofumi Kiyokawa, Hiroshi Yasuda, Chiaki Okuse, Nobuyuki Matsumoto, Toru Yoshimura, Eisaku Yoshida, Masatoshi Nakagawa, Motoharu Seiki, Naohiko Koshikawa, Fumio Itoh. SERUM MONOMERIC LAMININ-gamma 2 AS A NOVEL BIOMARKER FOR HEPATOCELLULAR CARCINOMA. GASTROENTEROLOGY. 2017. 152. 5. S298-S298

ｍore...

Patents (5)：

EphA2 N末端フラグメント抗体
がんの予後判定および診断方法
がんの検査方法及び検査用キット
がんの検査方法及び検査用キット
泌尿器科がんの検査方法及び検査用キット

Education (2)：

1990 - 1995 横浜市立大学大学院総合理学研究科
1986 - 1990 Yokohama City University

Work history (9)：

2020/06 - 現在 Kanagawa Cancer Center, Research Institute Clinical Oncoproteomics Guest Researcher
2020/06 - 現在 Tokyo Institute of Technology School of Life Science and Technology
2014/06 - 現在 The University of Tokyo The Institute of Medical Science
2014/04 - 2020/05 Kanagawa Cancer Center, Research Institute
2008/01 - 2014/03 The University of Tokyo Graduate School of Frontier Sciences Department of Medical Genome Sciences

Show all

Awards (3)：

2019/02 - 公益財団法人高松宮妃癌研究基金高松宮妃がん研究基金・助成金
2005/09 - 日本癌学会研究奨励賞
2000/06 - 日本がん転移学会研究奨励賞

Association Membership(s) (6)：

American Society for Matrix Biology (ASMB) , American Association for Cancer Research (AACR) , Japanese Association for Molecular Target Therapy of Cancer , The Japanese Biochemical Society , The Japanese Association for Metastasis Researc , Japanese Cancer Association (JCA)

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page