Hayakawa Koji

ハヤカワコウジ | Hayakawa Koji

Affiliation and department：

Research field (5)： Genomics , Cell biology , Genetics , Veterinary medicine , Genomics

Research keywords (10)： Epigenetics , Histone modifications , ゲノム進化 , O-GlcNAcylation , DNA methylation , metabolite , 栄養膜細胞 , Stem cells , germ cell-specific , Nutrino-genetics

Research theme for competitive and other funds (9)：

2023 - 2028 修飾ヒストンーノックダウン(MH-KD)法による治療抵抗性がん細胞の標的治療法の確立
2022 - 2026 Analysis of Molecular Mechanisms of Gestational Diabetes Mellitus by Histone O-GlcNAcylation and Establishment of Therapeutic Basis
2022 - 2024 新学術領域「グライコエピジェネティクス」の創生に向けた基盤研究
2020 - 2022 Study of nuclear-cytoplasmic incompatibility for the interspecies cloning.
2020 - 2022 Studies on molecular biology of intractable cancers focused on the interaction of epigenetics with autophagy

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Papers (29)：

Kenta Nishitani, Koji Hayakawa, Satoshi Tanaka. Epidermal growth factor represses differentiation of mouse trophoblast stem cells into spongiotrophoblast cells via epidermal growth factor receptor. Biochemical and Biophysical Research Communications. 2023. 657. 100-107
Kenta Nishitani, Koji Hayakawa, Masayuki Minatomoto, Keisuke Tanaka, Hidehiko Ogawa, Hirotatsu Kojima, Satoshi Tanaka. N-Oleoyldopamine promotes the differentiation of mouse trophoblast stem cells into parietal trophoblast giant cells. Biochemical and biophysical research communications. 2022. 636. Pt 1. 205-212
Koji Hayakawa, Satoshi Tanaka. Oocyte-specific linker histone H1foo interacts with Esrrb to induce chromatin decondensation at specific gene loci. Biochemical and Biophysical Research Communications. 2021. 561. 165-171
Protein Phosphatase 6 Promotes Neurite Outgrowth by Promoting mTORC2 Activity in N2a Cells. The Journal of Biochemistry. 2021. in press
Transcriptome analysis using patient iPSC-derived skeletal myocytes: Bet1L as a new molecule possibly linked to neuromuscular degeneration in ALS. Experimental Neurology. 2021. in press

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MISC (13)：

Investigating the epigenetic mechanisms of trophoblast giant cells. Research Features. 2018. 130. 31-33
廣澤瑞子, 早川晃司, 田中智, 塩田邦郎. O-グリコシル化. 生体の科学. 2018. 69. 5. 416-417
廣澤瑞子, 早川晃司, 田中智, 堂前直, 新井大祐, 塩田邦郎. 胎生動物出現の鍵 : 糖による新たなエピジェネティック修飾を発見「哺乳類に特有な病気の原因解明、治療開発に栄養学的観点から期待」. 東京大学大学院農学生命科学研究科プレスリリース. 2016
R. Tani, K. Hayakawa, S. Tanaka, K. Shiota. Linker histone variant H1T targets rDNA repeats. MOLECULAR BIOLOGY OF THE CELL. 2014. 25
C. Yoneda, K. Hayakawa, M. Hirosawa, S. Tanaka, K. Shiota. The influence of glucose concentration on the pluripotency of mouse embryonic stem cells. MOLECULAR BIOLOGY OF THE CELL. 2014. 25

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Patents (6)：

ナルコレプシーまたは摂食障害の治療剤
うつ治療剤
オレキシンニューロンの誘導法
高血糖によるエピゲノム異常の抑制のための方法及び組成物
糖感知エピゲノムバイオマーカー

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Books (3)：

薬理学・毒性学実験
文永堂出版 2023 ISBN:9784830032868
Epigenetic Methods in Neuroscience Research
Humana Press 2016
The Guide to Investigation of Mouse Pregnancy
Academic Press 2013

Lectures and oral presentations (31)：

Identification of nutrient metabolites capable of altering the epigenetic status at specific loci
(Experimental Biology 2019 2019)
Identification of nutrient metabolites capable of altering the epigenetic status at specific loci.
(2018)
Nucleosomes of polyploid trophoblast giant cells mostly consist of histone variants and form an unstable chromatin structure.
(4th World Congress of Reproductive Biology 2018)
エピジェネティック調節に関わる栄養代謝中間体の探索
(第12回日本エピジェネティクス研究会年会 2018)
ヒストンH2A O-GlcNAc修飾による哺乳類特有DNA修復機構
(第11回日本エピジェネティクス研究会年会 2017)

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Professional career (1)：

博士 (農学) (東京大学)

Work history (4)：

2023/04 - 現在 Okayama University of Science Faculty of Veterinary Medicine Associate Professor
2019/06 - 2023/03 Okayama University of Science Faculty of Veterinary Medicine Lecturer
2012/04 - 2019/05 The University of Tokyo Graduate School of Agricultural and Life Sciences Animal Resource Sciences
2010/04 - 2012/03 The University of Tokyo Graduate School of Agricultural and Life Sciences Animal Resource Sciences

Awards (4)：

2022/03 - Okayama University of Science President's Special Prize
2015/03 - 公益財団法人ロッテ財団ロッテ重光学術賞エピジェネティクス情報を利用した栄養素の選択
2013/11 - 東京大学優駿会ヤンソン賞創薬と再生医療を目指した幹細胞からの神経細胞の再生
2011/09 - 日本繁殖生物学会第104回日本繁殖生物学会年会最優秀発表賞卵特異的ヒストンH1fooはDNAメチル化プロフィール形成に関与する

Association Membership(s) (6)：

日本生化学会 , The Japanese Society for Regenerative Medicine , The Japanese Society of Toxicology , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , The Japanese Society for Epigenetics , SOCIETY FOR REPRODUCTION AND DEVELOPMENT

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