Yuki Toda

Research field (2)： Hematology and oncology , Pharmaceuticals - health and biochemistry

Research keywords (3)：がん転移 , がん微小環境 , 低酸素

Research theme for competitive and other funds (4)：

2023 - 2027 Identification of factor to induce lactic acidosis in pre-metastatic niche
2020 - 2023 Hypoxic adaptation of myeloma stem cells by secreting miRNA throuhg exosomes
2019 - 2022 Development of exosome-capturing antibody-conjugated nucleic acid medicines against multiple myeloma
2014 - 2016 エクソソームのがん細胞指向性解析に基づく高選択的薬物送達法の開発

Papers (22)：

Daiki Shimizu, Miku Ishibashi, Tadaaki Yamada, Yuki Toda, Shigekuni Hosogi, Eishi Ashihara. POLD1 Is Required for Cell Cycle Progression by Overcoming DNA Damage in Malignant Pleural Mesothelioma. Cancer genomics & proteomics. 2024. 21. 2. 158-165
Yusuke Sano, Naoko Kuwabara, Saori Nakagawa, Yuki Toda, Shigekuni Hosogi, Shinji Sato, Eishi Ashihara. Hypoxia-adapted Multiple Myeloma Stem Cells Resist γδ-T-Cell-mediated Killing by Modulating the Mevalonate Pathway. Anticancer research. 2023. 43. 2. 547-555
Toma Matsui, Yuki Toda, Haruka Sato, Rina Itagaki, Kazuya Konishi, Anna Moshnikova, Oleg A Andreev, Shigekuni Hosogi, Yana K Reshetnyak, Eishi Ashihara. Targeting acidic pre-metastatic niche in lungs by pH low insertion peptide and its utility for anti-metastatic therapy. Frontiers in oncology. 2023. 13. 1258442-1258442
Yuki Sugiyama, Seikou Nakamura, Yuichi Tokuda, Masakazu Nakano, Yasunao Hattori, Hiroki Nishiguchi, Yuki Toda, Shigekuni Hosogi, Masayuki Yamashita, Kei Tashiro, et al. 7,8-Dihydroxy-3-(4′-hydroxyphenyl)coumarin inhibits invasion and migration of osteosarcoma cells. Biochemical and Biophysical Research Communications. 2023. 638. 200-209
Emi Soma, Asako Yamayoshi, Yuki Toda, Yuji Mishima, Shigekuni Hosogi, Eishi Ashihara. Successful Incorporation of Exosome-Capturing Antibody-siRNA Complexes into Multiple Myeloma Cells and Suppression of Targeted mRNA Transcripts. Cancers. 2022. 14. 3. 566-566

ｍore...

MISC (2)：

芦原英司, 今吉菜月, Yoshioka Makoto, 中田晋, Chauhan Jay, 戸田侑紀, Fletcher Steven, Strovel Jeffrey, 高田和幸. 新規治療薬基礎新規ブロモドメイン阻害剤CG13250の多発性骨髄腫に対する抗腫瘍効果. International Journal of Myeloma. 2017. 7. 1. 41-41
Natsuki Imayoshi, Makoto Yoshioka, Susumu Nakata, Jay Chauhan, Yoko Kado, Yuki Toda, Steven Fletcher, Jeffrey Strovel, Kazuyuki Takata, Eishi Ashihara. A Novel BRD4 Inhibitor CA2 Suppresses MM Cell Proliferation in an Orthotopic Myeloma Mouse Model. BLOOD. 2016. 128. 22

Awards (2)：

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