Rchr
J-GLOBAL ID：201801007270516567   Update date: Feb. 01, 2024

Yuko Hirota

ヒロタ ユウコ | Yuko Hirota
Affiliation and department：
Kyushu University

About Kyushu University


Research field  (1)： Pharmaceuticals - health and biochemistry
Research keywords  (2)： autophagy ,  lysosome
Research theme for competitive and other funds  (9)：
  • 2017 - 2022 Assessment of the impact of the disturbance in endo-and-xeno environment on the next-generation: study on the mechanism for sexual immaturity and developmental disorders and the preventive method
  • 2020 - 2022 リソソーム膜タンパク質LAPTM4βによる多剤耐性獲得機構の解明
  • 2018 - 2018 リソソーム膜タンパク質LAPTM4αによる多剤耐性獲得およびその基質特異性に関する研究
  • 2017 - 2017 リソソーム膜タンパク質による新規多剤耐性獲得機構の解明
  • 2015 - 2017 Lysosomal membrane protein LAPTM4a functions in multiple drug resistance.
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Papers (24)：
  • Yuu Miyauchi, Akane Kimura, Madoka Sawai, Keiko Fujimoto, Yuko Hirota, Yoshitaka Tanaka, Shinji Takechi, Peter I. Mackenzie, Yuji Ishii. Use of a Baculovirus-Mammalian Cell Expression-System for Expression of Drug-Metabolizing Enzymes: Optimization of Infection With a Focus on Cytochrome P450 3A4. Frontiers in Pharmacology. 2022. 13
  • Hong-Bin Chen, Jorge Carlos Pineda Garcia, Shinako Arizono, Tomoki Takeda, Ren-Shi Li, Yukiko Hattori, Hiroe Sano, Yuu Miyauchi, Yuko Hirota, Yoshitaka Tanaka, et al. DAPL1 is a novel regulator of testosterone production in Leydig cells of mouse testis. Scientific reports. 2021. 11. 1. 18532-18532
  • Yuko Hirota, Masaharu Hayashi, Yuu Miyauchi, Yuji Ishii, Yoshitaka Tanaka, Keiko Fujimoto. LAPTM4α is targeted from the Golgi to late endosomes/lysosomes in a manner dependent on the E3 ubiquitin ligase Nedd4-1 and ESCRT proteins. Biochemical and biophysical research communications. 2021. 556. 9-15
  • Yuu Miyauchi, Ken Kurohara, Akane Kimura, Madoka Esaki, Keiko Fujimoto, Yuko Hirota, Shinji Takechi, Peter I. Mackenzie, Yuji Ishii, Yoshitaka Tanaka. The carboxyl-terminal di-lysine motif is essential for catalytic activity of UDP-glucuronosyltransferase 1A9. Drug Metabolism and Pharmacokinetics. 2020. 35. 5. 466-474
  • Keiko Fujimoto, Sanae Nakashima, Shotaro Uchida, Riham N.S. Amen, Yuji Ishii, Yuko Hirota, Yoshitaka Tanaka. HM1.24/BST-2 is constitutively poly-ubiquitinated at the N-terminal amino acid in the cytoplasmic domain. Biochemistry and Biophysics Reports. 2020. 23. 100784-100784
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MISC (4)：
  • Sora Kimura, Yuu Miyauchi, Yuko Hirota, Yoshitaka Tanaka, Peter I. Mackenzie, Hideyuki Yamada, Yuji Ishii. MECHANISM FOR THE RETENTION OF UDP-GLUCURONOSYLTRANSFERASE 2B7 IN THE ENDOPLASMIC RETICULUM: THE ROLE OF THE LUMINAL DOMAIN. DRUG METABOLISM REVIEWS. 2015. 47. 62-62
  • Yuko Hirota, Yoshimasa Aoki, Tomotake Kanki. Mitophagy: Selective degradation of mitochondria by autophagy. Seikagaku. 2011. 83. 2. 126-130
  • Yuko Hirota, Yoshitaka Tanaka. A small GTPase, human Rab32, is required for the formation of autophagic vacuoles under basal conditions. AUTOPHAGY. 2009. 5. 6. 900-900
  • IKEDA Kazuhiko, SANO Koichi, HIRAYAMA Masahiro, HIROTA Yuko, TANAKA Yoshitaka. A Novel in vitro Screening System for Detecting Drug-Induced Phospholipidosis. Annual Meeting of the Japanese Society of Toxicology. 2008. 35. 0. 279-279
Books (1)：
  • Autophagy - A Double-Edged Sword - Cell Survival or Death? "Rab GTPases in Autophagy"
    InTech 2013
Lectures and oral presentations  (39)：
  • ESCRT非依存的分解経路によるLAPTM4αの細胞内動態
    (第74回日本細胞生物学会大会 2022)
  • Death associated protein-like 1 (DAPL1) の特性検討:細胞内局在およびテストステロン産生調節作用
    (日本薬学会 第142年会 2022)
  • Death-associated protein-like 1 (DAPL1) in regulating testosterone production: study using Dapl1-null mice and testis-derived I-10 tumor Leydig cells
    (24th North American ISSX Meeting 2021 2021)
  • ESCRTタンパク質Hrsによるリソソーム膜タンパク質LAPTMαの細胞内輸送制御機構
    (第73回日本細胞生物学会大会 2021)
  • 新規シトクロムP450 3A4 発現系の構築:バキュロウイルスを用いた COS-1細胞における過剰発現
    (日本薬学会 第141年回 2021)
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Education (3)：
  • 2005 - 2008 Kyushu University Graduate School of Pharmaceutical Sciences
  • 2003 - 2005 Kyushu University Graduate School of Pharmaceutical Sciences
  • 1999 - 2003 Kyushu University School of Pharmaceutical Sciences
Professional career (1)：
  • 博士(薬学)
Work history (3)：
  • 2013/07 - 現在 Kyushu University Faculty of Pharmaceutical Sciences
  • 2013/01 - 2013/06 Niigata University Graduate School of Medical and Dental Sciences
  • 2010/04 - 2012/12 Kyushu University Faculty of Medical Sciences
Committee career (4)：
  • 2022/04 - 現在 九州大学 薬学研究院等ハラスメント等防止委員会委員
  • 2020/04 - 2021/06 九州大学 毒劇物管理委員
  • 2015/10 - 2021/03 九州大学 動物実験委員会委員
  • 2013/07 - 2017/03 九州大学 毒劇物管理委員
Awards (1)：
  • 2014/12 - 第14回日本ミトコンドリア学会 ベストプレゼンテーション賞
Association Membership(s) (3)：
THE JAPANESE SOCIETY OF MITOCHONDRIAL RESEARCH AND MEDICINE ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  JAPAN SOCIETY FOR CELL BIOLOGY
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