Rchr

J-GLOBAL ID：201801007452437948 Update date: Oct. 20, 2024

KITAYAMA JOJI

キタヤマジョウジ | KITAYAMA JOJI

Affiliation and department：

Research field (1)： Digestive surgery

Research keywords (2)： cancer immunotherapy , peritoneal metastasis

Research theme for competitive and other funds (51)：

2023 - 2026 体組成変化と大腸癌肝転移の転移機構の解明と新規治療戦略の開発
2023 - 2026 Development of novel therapy targeting microRNA for peritoneal dissemination and elucidation of its immunological mechanism
2023 - 2025 Development of novel cancer diagnosis system using innovative ionization mass spectrometry using body fluid samples
2022 - 2025 Role of neutrophil extracellular traps in the pathophysiology of colorectal cancer
2022 - 2025 化学放射線療法耐性直腸癌に対するフェロトーシス誘導療法の開発

2022 - 2025 Role of neutrophil extracellular traps on pathophysiology of diabetes-associated cancer

2021 - 2024 Oncological significance of vagotomy in upper gastrointestinal surgery

2021 - 2024 Role of trogositosis in tumor immune escape

2021 - 2024 Significance of neutrophil extracellular traps in the formation of pre-metastatic niches by exosomes

2020 - 2023 Novel method to prevent peritoneal recurrence using nuclear medicine

2020 - 2023 Development of intraperitoneal immunotherapy for peritoneal metastasis

2020 - 2022 Integrated understanding of peritoneal dissemination for drug delivery based on multi-scale reaction-diffusion model

2019 - 2022 The involvement of Neutrophil extracellular traps (NETs) in the development of peritoneal metastasis in terms of the interaction with host immunity

2019 - 2022 Novel radioimmunotherapy for rectal cancer based on the tumor metabolism

2018 - 2021 Role of smooth muscle cells in invasion and metastasis of scirrhous gastric cancer

2018 - 2020 Intrathoracic duct chemotherapy targeted to metastatic abdominal lymph nodes

2017 - 2020 Intraperitoineal exosome as a novel target for peritoneal metastasis

2017 - 2020 Neutrophil extracellular traps in the development of peritoneal metastasis

2017 - 2020 Radiation and immune checkpoint inhibition for the treatment of advanced rectal cancer with distant micrometastasis

2017 - 2020 Study for therapeutic strategy of pancreatic cancer using microRNA expresssion profiles

2016 - 2019 Analysis of regulatory mechanism of inflammatory cytokine by miRNAs and development to novel treatment.

2015 - 2018 Establishment of the novel bio-marker for early detection and monitoring of gastric cancer with peritoneal dissemination

2014 - 2017 Development of new treatments of peritoneal disorders using multi-layered, in situ cross-likable hydrogels

2012 - 2015 Establishment of radioimmunotherapy for advanced rectal cancer; Induction of efficient abscopal effect

2012 - 2015 Distribution analysis of intraperitoneally administrated nanomicellar drugsin peritoneal metastasis

2012 - 2014 Role of autophagy in immunoescape of solid tumor

2012 - 2014 Cancer stem cell for peritoneal metastasis in abdominal cavity

2011 - 2013 Development of cisplutium binding hialulonic acid gel as a novel intraperitoneal chemotherapeutic agent for peritoneal dissemination of gastric cancer

2009 - 2011 がんの発育・放射線化学療法抵抗性に関与する脂肪由来アディポカインの機能解析

2009 - 2011 Analysis of the PI3K pathway in colon cancer and new strategy of Molecular target-based drugs.

2008 - 2010 Paclitaxel combined with hyarulonic acid as the new drug for peritoneal dissemination of gastric cancer.

2005 - 2008 Treatment strategy for colorectal cancer targeted to the tumor vessel

2006 - 2007 植物由来イソプレノイドの抗腫瘍効果および抗血管新生作用についての検討

2004 - 2006 Novel strategy of anti-cancer therapy targeted the bioactive phospholipids.

2004 - 2005 磁気マイクロビーズを用いた胃癌腹膜播腫治療法の開発

2003 - 2004 外科疾患における血管内皮前駆細胞の動態の検討

2001 - 2003 Synthetic analysis of metastasis related molecules from clinical point of view.

2001 - 2002 The new establishment of the detection for metastatic sentinel lymph nodes by using radio-labelled specific monoclonal antibody of the cancer

2000 - 2002 癌の血行性転移と血小板型(HPA)との相関性についての臨床的検討

2000 - 2001 The mechanism analysis and practical application of apoptosis induct of metastasis related gene.

1999 - 2001 Development of a New Stragegy for Cancer Treatment by Targeting Tumor Vascular Endothelium Using Monoclonal Antibodies

2000 - 2000 腫瘍抽出RNAの導入樹状細胞を用いた抗腫瘍免疫療法の開発

1999 - 2000 Establishment of the anti-tumor immunotherapy using dendritic cells transfected with tumor extracted RNA

1999 - 2000 ShearStress存在下における癌細胞着床現象の動的解析

1999 - 2000 癌浸潤関連物質に対する抗体を用いた新たなターゲッティング療法の試み

1999 - 1999 がんのリンパ節転移における癌細胞着床機構の動的解析

1998 - 1999 Expression of chemokines in gastrointestinal cancer

1996 - 1999 Integrated mutation analysis in colorectal cancer

1996 - 1998 Basic study of polynucleotide vaccine for tumor immunotherapy

1994 - 1995 THE BASIC AND CLINICAL STUDY OF METASTASIS IN ESOPHAGEAL CANCER--THE CORRELATION OF EXPRESSION OF ADHESION MOLECULES WITH METASTASIS--

1993 - 1995 Detection of gene mutation by laser spectroscopic analysis for cancer cell line

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Papers (601)：

Yuki Kaneko, Hideyuki Ohzawa, Yuki Kimura, Rei Takahashi, Misaki Matsumiya, Kohei Tamura, Yurie Futoh, Hideyo Miyato, Shin Saito, Hironori Yamaguchi, et al. Intraperitoneal administration of adeno-associated virus encoding microRNA-29b for the treatment of peritoneal metastasis. Cancer gene therapy. 2024
Kohei Tamura, Natsuka Kimura, Hideyuki Ohzawa, Hideyo Miyato, Naohiro Sata, Takahiro Koyanagi, Yasushi Saga, Yuji Takei, Hiroyuki Fujiwara, Ryozo Nagai, et al. Optimizing Timing of Intraperitoneal Chemotherapy to Enhance Intravenous Carboplatin Concentration. Cancers. 2024. 16. 16. 2841-2841
Takehiro Kagaya, Atsushi Miki, Jun Watanabe, Rihito Kanamaru, Shiro Matsumoto, Kentaro Kurashina, Shin Saito, Takumi Teratani, Yoshinori Hosoya, Yasunaru Sakuma, et al. Preoperative osteopenia is associated with prognosis in patients after resection of esophageal cancer. World Journal of Surgery. 2024
津久井秀則, 堀江久永, 村橋賢, 利府数馬, 本間祐子, 東條峰之, 佐田友藍, 森和亮, 太白健一, 太田学, et al. 当院における直腸癌術前化学放射線療法施行症例に対する側方郭清の適応. 日本大腸肛門病学会雑誌. 2024. 77. 6. 386-386
Takashi Ishida, Atsushi Miki, Yasunaru Sakuma, Jun Watanabe, Kazuhiro Endo, Hideki Sasanuma, Takumi Teratani, Joji Kitayama, Naohiro Sata. Preoperative Bone Loss Predicts Decreased Survival Associated with Microvascular Invasion after Resection of Hepatocellular Carcinoma. Cancers. 2024. 16. 11. 2087-2087

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MISC (331)：

Yurie Futoh, Hideyo Miyato, Misaki Matsumiya, Rei Takahashi, Yuki Kaneko, Kazuya Takahashi, Yuki Kimura, Hiroko Hayakawa, Hideyuki Ohzawa, Naohiro Sata, et al. Effects of vagus nerve signals on the development of peritoneal metastasis of murine gastric cancer. CANCER RESEARCH. 2023. 83. 7
山口博紀, 山口博紀, 大澤英之, 大澤英之, 知念崇, 金丸理人, 倉科憲太郎, 斎藤心, 細谷好則, 佐田尚宏, et al. 高齢者におけるがん薬物療法. 日本成人病(生活習慣病)学会会誌. 2022. 47
風當ゆりえ, 風當ゆりえ, 北山丈二, 北山丈二, 金子勇貴, 金子勇貴, 高橋和也, 高橋和也, 木村有希, 木村有希, et al. 大腸癌患者の術後末梢血中低比重好中球と予後の関連性. 日本大腸肛門病学会雑誌(Web). 2022. 75. 9
齋藤晶, 松宮美沙希, 高橋礼, 風當ゆりえ, 金子勇貴, 田村昂平, 高橋和也, 木村有希, 宮戸秀世, 大澤英之, et al. Significance of neutrophil extracellular traps (NETs) in tumor microenvironment of colon cancer with diabetes mellitus. 日本消化器癌発生学会総会プログラム・抄録集. 2022. 33rd
風當ゆりえ, 風當ゆりえ, 宮戸秀世, 宮戸秀世, 松宮美沙希, 高橋礼, 金子勇貴, 高橋和也, 木村有希, 松宮美沙希, et al. Phenotypic change of intraperitoneal macrophage by peritoneal metastasis. 日本消化器癌発生学会総会プログラム・抄録集. 2022. 33rd

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Lectures and oral presentations (1,163)：

膵内多発腫瘤の1例
(膵臓 2021)
Flow cytometryを用いた胃癌患者腹腔内遊離癌細胞・免疫細胞の解析
(日本消化器外科学会総会 2021)
Stage IV胃癌に対するConversion surgeryの課題と展望 IP-PTX+SOX療法に奏功を認めた腹膜播種陽性胃癌症例に対するconversoin surgeryの適応と成績
(日本消化器外科学会総会 2021)
コロナ感染症対策下のおける当科の臨床実習について
(医学教育 2021)
自治医科大学附属病院における、初期臨床研修医に対する外科研修
(医学教育 2021)

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Professional career (1)：

医学博士 (東京大学)

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