Rchr
J-GLOBAL ID:201801007885084594   Update date: Apr. 24, 2024

Ohigashi Izumi

Ohigashi Izumi
Affiliation and department:
Research field  (1): Immunology
Research theme for competitive and other funds  (8):
  • 2022 - 2025 自己免疫疾患とガンの病態に関与するケモカインCCL21の発現制御メカニズムの研究
  • 2021 - 2024 膵β細胞特異的Prss53の分子メカニズム
  • 2017 - 2020 胸腺上皮細胞分岐分子メカニズムの研究
  • 2016 - 2020 胸腺における「正の選択」の本質を問う
  • 2015 - 2017 Molecular mechanism of the development of thymic epithelial cells
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Papers (71):
  • Ohigashi Izumi, White Andrea, Yang Mei-Ting, Fujimori Sayumi, Tanaka Yu, Jacques Alison, Kiyonari Hiroshi, Matsushita Yosuke, Turan Sevilay, Kelly Michael, et al. Developmental conversion of thymocyte-attracting cells into self-antigen-displaying cells in embryonic thymus medulla epithelium. eLife. 2024. Vol.12. RP92552-RP92552
  • Ryonosuke Fujie, Kaoru Kurowarabe, Yuki Yamada, Kakeru Fujiwara, Hayata Nakatani, Kenta Tsutsumi, Ryota Hayashi, Hinami Kawahata, Megumi Miyamoto, Madoka Ozawa, et al. Endogenous CCL21-Ser deficiency reduces B16-F10 melanoma growth by enhanced antitumor immunity. Heliyon. 2023. Vol.9. No.8
  • Lucas B, White AJ, Klein F, Veiga-Villauriz C, Handel A, Bacon A, Cosway EJ, James KD, Parnell SM, Ohigashi Izumi, et al. Embryonic keratin19+ progenitors generate multiple functionally distinct progeny to maintain epithelial diversity in the adult thymus medulla. Nature Communications. 2023. Vol.14. No.1. 2066-2066
  • Izumi Ohigashi, Mami Matsuda-Lennikov, Yousuke Takahama. Large-Scale Isolation of Mouse Thymic Epithelial Cells. Methods in molecular biology (Clifton, N.J.). 2023. 2580. 189-197
  • Yang Zhang, Laura Garcia-Ibanez, Carolin Ulbricht, Laurence S. C. Lok, Jeremy A. Pike, Jennifer Mueller-Winkler, Thomas W. Dennison, John R. Ferdinand, Cameron J. M. Burnett, Juan C. Yam-Puc, et al. Recycling of memory B cells between germinal center and lymph node subcapsular sinus supports affinity maturation to antigenic drift. Nature Communications. 2022. 13. 1
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MISC (18):
  • Fujimori Sayumi, Ohigashi Izumi. Diversity and differentiation pathways of medullary thymic epithelial cells. Clinical Immunology & Allergology. 2024. Vol.81. No.4
  • Fujimori Sayumi, Ohigashi Izumi. The role of thymic epithelium in thymus development and age-related thymic involution. The Journal of Medical Investigation : JMI. 2024. Vol.71. No.1,2. 29-39
  • Matsui Naoko, Ohigashi Izumi, Izumi Yuishin. 重症筋無力症と胸腺摘出. 脳神経内科. 2023. Vol.98. No.6. 823-828
  • Ohigashi Izumi. 胸腺プロテアソームとTCRレパトア選択. Clinical Immunology & Allergology. 2021. Vol.76. No.5. 567-572
  • Fujimori Sayumi, Ohigashi Izumi. 胸腺上皮細胞の動態:胎生期での発生,成体での維持,加齢に伴う退縮. Inflammation & Immunology. 2021. Vol.29. No.6. 491-495
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Books (3):
  • Large-scale isolation of mouse thymic epithelial cells
    2022
  • 免疫生物学(原書第9版) 監訳 笹月健彦,吉開泰信
    Nankodo 2019
  • Thymocyte-mTEC cross talk for self-tolerance in T cells.
    Elsevier 2016
Lectures and oral presentations  (104):
  • ケモカインCCL21を発現する胎仔期の胸腺髄質上皮細胞は自己抗原発現髄質上皮細胞への分化活性を有する
    (第46回日本分子生物学会年会 2023)
  • Role of β-catenin in mouse thymic epithelial cells for postnatal thymic development
    (The 18th International Symposium of the Institute Network for Biomedical Sciences 2023)
  • ケモカインCCL21を発現する胸腺髄質上皮細胞は自己抗原発現髄質上皮細胞への分化活性を有する
    (第32回 Kyoto T Cell Conference 2023)
  • Role of β-catenin in thymic epithelial cells for postnatal thymic development and involution
    (ThymOz International Conference on T Cells: ThymOz 2023 2023)
  • Developmental conversion of thymocyte-attracting cells into self-antigen-displaying cells in thymus medulla epithelium
    (ThymOz International Conference on T Cells: ThymOz 2023 2023)
more...
Awards (2):
  • 2019/05/20 - FEBS Letters FEBS Letters Poster Award Trans-omics impact of thymoproteasome in cortical thymic epithelial cells
  • 2013/11/07 - Tokushima University 若手研究者学長表彰受賞 胸腺上皮細胞亜集団の分化・分岐機構の研究
Association Membership(s) (1):
Japanese Society for Immunology
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