Okada Masashi

オカダマサシ | Okada Masashi

Research field (1)： Tumor biology

Research keywords (6)： p53 , c-Jun N-terminal kinase (JNK) , inositol phospholipids metabolic enzymes , drug repositioning , drug resistance , cancer stem cells

Research theme for competitive and other funds (5)：

2020 - 2023 酸化的リン酸化を標的とした新規がん幹細胞標的治療戦略の開発
2016 - 2018 Taking advantage of a pitfall in glioma cancer stem cell epigenetics to develop novel therapies directed to cancer stem cells
2015 - 2017 An attempt to answer the cardinal question --- why do cancer cells have such a sweet tooth? --- through glioma stem cell research
2008 - 2011 Functional role of lipid second messenger metabolizing enzyme in cell cycle and stress response
2003 - 2006 細胞核におけるイノシトールリン脂質情報伝達系の制御機構と生理的意義の解明

Papers (115)：

Shuhei Suzuki, Chifumi Kitanaka, Masashi Okada. Melanocortin Receptor Agonist Bremelanotide Induces Cell Death and Growth Inhibition in Glioblastoma Cells via Suppression of Survivin Expression. Anticancer research. 2024. 44. 9. 3875-3883
Yuta Mitobe, Shuhei Suzuki, Kazuki Nakamura, Yurika Nakagawa-Saito, Senri Takenouchi, Keita Togashi, Asuka Sugai, Yukihiko Sonoda, Chifumi Kitanaka, Masashi Okada. CEP-1347 Boosts Chk2-Mediated p53 Activation by Ionizing Radiation to Inhibit the Growth of Malignant Brain Tumor Cells. International journal of molecular sciences. 2024. 25. 17
Yurika Nakagawa-Saito, Yuta Mitobe, Keita Togashi, Shuhei Suzuki, Asuka Sugai, Senri Takenouchi, Kazuki Nakamura, Yukihiko Sonoda, Chifumi Kitanaka, Masashi Okada. The MDM2-p53 Axis Represents a Therapeutic Vulnerability Unique to Glioma Stem Cells. International journal of molecular sciences. 2024. 25. 7
Keita Togashi, Shuhei Suzuki, Yuta Mitobe, Yurika Nakagawa-Saito, Asuka Sugai, Senri Takenouchi, Masahiko Sugimoto, Chifumi Kitanaka, Masashi Okada. CEP-1347 Dually Targets MDM4 and PKC to Activate p53 and Inhibit the Growth of Uveal Melanoma Cells. Cancers. 2023. 16. 1
Yuta Mitobe, Shuhei Suzuki, Yurika Nakagawa-Saito, Keita Togashi, Asuka Sugai, Yukihiko Sonoda, Chifumi Kitanaka, Masashi Okada. Antagonizing MDM2 Overexpression Induced by MDM4 Inhibitor CEP-1347 Effectively Reactivates Wild-Type p53 in Malignant Brain Tumor Cells. Cancers. 2023. 15. 17

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MISC (45)：

山本雅大, 冨樫敬太, 鈴木修平, 佐野町友美, 清野静香, 岡田雅司, 北中千史. Sleeping Beautyトランスポゾン法を用いたマウス肝発がん実験. 山形医学. 2019. 37. 2. 76-76
Okada Masashi, Suzuki Shuhei, Seino Manabu, Takeda Hiroyuki, Kitanaka Chifumi. The novel JNK inhibitor AS602801 inhibits cancer stem cells in vitro and in vivo. CANCER SCIENCE. 2018. 109. 269
岡田雅司, 鈴木修平, 倉元謙太, 武田弘幸, 北中千史. がん幹細胞におけるJNK経路の機能解析. 生命科学系学会合同年次大会. 2017. 2017年度. [1P-0950]
岡田雅司, 鈴木修平, 清野学, 武田弘幸, 北中千史. 新規JNK阻害薬であるAS602801はがん幹細胞を抑制する. 日本癌学会総会記事. 2017. 76回. P-1197
鈴木修平, 鈴木修平, 吉岡孝志, 岡田雅司. JNKシグナル経路を標的としたがん幹細胞の治療戦略. 月刊細胞. 2017. 49. 3. 136-138-138

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Patents (1)：

ガン抑制薬及び抗腫瘍剤、腫瘍再発防止剤、腫瘍発生予防剤

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