Research theme for competitive and other funds (3)：
2021 - 2024 LPA受容体シグナルを介するがん細胞の抗がん剤・放射線感受性調節機構の解明
2020 - 2022 Mechanism elucidation of bystander effects focusing on DNA repair in radioresistant chondrosarcoma cells
2017 - 2018 細胞周期分布と修復動態に着目した放射線誘発バイスタンダー効果の解析
Papers (16)：
Hiroko Ikeda, Miwa Takai, Narumi Yashiro, Yuka Amano, Koki Hara, Mao Yamamoto, Toshifumi Tsujiuchi. Regulation of cellular responses to X-ray irradiation through the activation of lysophosphatidic acid (LPA) receptor-3 (LPA3) and LPA2 in osteosarcoma cells. Pathology - Research and Practice. 2024. 257. 155293-155293
Nho Cong Luong, Hidemasa Kawamura, Hiroko Ikeda, Reiko T. Roppongi, Atsushi Shibata, Jiaxuan Hu, Jinmeng G. Jiang, David S. Yu, Kathryn D. Held. ATR signaling controls the bystander responses of human chondrosarcoma cells by promoting RAD51-dependent DNA repair. International Journal of Radiation Biology. 2024. 1-12
Hiroko Ikeda, Miwa Takai, Toshifumi Tsujiuchi. Lysophosphatidic acid (LPA) receptor-mediated signaling and cellular responses to anticancer drugs and radiation of cancer cells. Advances in Biological Regulation. 2024. 92. 101029-101029
Polina Malatesta, Konstantinos Kyriakidis, Megumi Hada, Hiroko Ikeda, Akihisa Takahashi, Premkumar B. Saganti, Alexandros G. Georgakilas, Ioannis Michalopoulos. Differential Gene Expression in Human Fibroblasts Simultaneously Exposed to Ionizing Radiation and Simulated Microgravity. Biomolecules. 2024. 14. 1. 88
Aya Okuda, Miwa Takai, Rio Kurisu, Miyu Takamoto, Hiroko Ikeda, Toshifumi Tsujiuchi. Roles of lysophosphatidic acid (LPA) receptor-2 (LPA 2 ) in the regulation of cellular responses induced by X-ray irradiation and hydrogen peroxide in pancreatic cancer cells. International Journal of Radiation Biology. 2023. 99. 12. 1925-1933
Ikeda H, Yokota Y, Funayama T, Takahashi A, Kanai T, Nakano T, Kobayashi Y. Analysis of Gamma-ray Induced Bystander Effect between Human Lung Normal and Cancer Cells. QST Takasaki Annual Report 2015. 2016. 111
Differential gene expression in human fibroblasts using a Simulator of the environments on the Moon and Mars with Neutron-irradiation and Gravity change (SwiNG)
(ISRN2024 2024)
Effects of fractionated X-ray Irradiation on acquired radiation resistance and maintenance of osteosarcoma cells
(2023)
DIFFERENTIAL GENE EXPRESSION IN HUMAN FIBROBLASTS SIMULTANEOUSLY EXPOSED TORADIATION AND SIMULATED MICROGRAVITY
(2023 NASA Human Research Program Investigators’ Workshop 2023)
CHROMOSOME ABERRATIONS IN HUMAN CELLS INDUCED BY SIMULTANEOUSLY EXPOSED TO PARTIAL GRAVITY AND LOW DOSE-RATE NEUTRONS
(NASA HRP IWS meeting 2023 2023)
Chromosome aberration induction by simulation environment of outer space, Moon and Mars
(2022)
2012 - 2017 Gunma University Graduate School of Medicine PhD Course of Medical Sciences
2010 - 2012 Gunma University Graduate School of Medicine Master Course of Biomedical Sciences
2006 - 2010 Kindai University Faculty of Science and Engineering Department of Life Science
Professional career (1)：
Ph.D. (Medicine) (Gunma University)
Work history (2)：
2020/04 - 現在 Kindai University Faculty of Science and Engineering, Department of Life Science Assistant professor
2017/04 - 2020/03 Gunma University Initiative for Advanced Research International Open Laboratory (Dr. Held lab, Harvard Medical School / MGH) Postdoctoral researcher
2017/09 - Japanese Society for Biological Sciences in Space Young Investigator Award
2012/11 - Atomic Energy Society of Japan, Kanto-Koetsu Branch (11th Young Researcher’s Presentation and Discussion Meeting) Award for Emerging Technology
Association Membership(s) (6)：
YOUNG RADIATION BIOLOGISTS' ASSOCIATION OF JAPAN
, THE JAPAN MICROBEAM BIOLOGY RESEARCH ASSOCIATION
, THE JAPANESE SOCIETY FOR BIOLOGICAL SCIENCES IN SPACE
, THE JAPANESE RADIATION RESEARCH SOCIETY
, 日本量子医科学会
, 日本癌学会
