Rchr
J-GLOBAL ID：201801008514787998
Update date: Nov. 15, 2024
Kodama Tatsuhiko
コダマ タツヒコ | Kodama Tatsuhiko
Affiliation and department：
Job title：
Cancer-Metabolism Project Leader/Professor emeritus
Homepage URL (1)：
https://ganwit.jhocc.jp/
Research field (1)：
Molecular biology
Research theme for competitive and other funds (41)：
- 2012 - 2015 Elucidation of the pathogenesis of kidney disease via epigenetic responses against hypoxia
- 2009 - 2012 Histone demethylase Jmjd1a as a regulator of glycolipid metabolism
- 2009 - 2011 Elucidation of the pathophysiology of chronic kidney disease by comprehensive analysis of the hypoxia-responsive transcriptional network
- 2004 - 2005 Molecule target search and development of new anti-rejection therapy in the transcriptome analysis of an organ transplantation
- 2003 - 2004 Activation of Arterial Wall Cells during Atherogenesis : A study using a in vitor co-culture model system
- 2001 - 2003 Genomic analysis of mutational genetic events in the genes involved in gastroenterological cancer progression.
- 2001 - 2002 Transcriptome Analysis of Atherosclerosis
- 2000 - 2002 Development of a gene set and monoclonal antibodies for the diagnosis of hepatocellular carcinoma.
- 1997 - 2001 動脈硬化の分子機構
- 1999 - 2000 The Analysis of Proteolytic Enzymes for SREBP and Its Application to Drug Discovery
- 1998 - 2000 Identification of tumor suppressor genes involved in multi-step gastrointestinal carcinogenesis
- 1999 - 1999 癌細胞染色体欠失領域からの癌抑制遺伝子の同定と新規遺伝子ZAP1の機能解析
- 1998 - 1999 Development of cell handling system under optical microscope
- 1997 - 1999 Development of a rapid scanning method for quantitative and qualitative variation throughout the genome.
- 1998 - 1998 癌細胞染色体欠失領域に存在する癌抑制遺伝子の同定と機能解析
- 1997 - 1998 Transcriptional regulation of cholesterol metabolism
- 1996 - 1998 Pathological Significance of Macrophage Scavenger Receptors
- 1997 - 1997 次世代医用生体工学のための生体内における熱・物質・電磁波の輸送・伝播に関する研究
- 1997 - 1997 癌抑制遺伝子座のゲノム構造解析:ゲノムシークエンシングによる発癌機構の解明
- 1997 - 1997 A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
- 1996 - 1997 A role for macrophage scavenger receptors in altherosclerosis and susceptibility to infection
- 1995 - 1997 Analysis of HCV derived RNA polymerase expressed in mammalian cell live
- 1996 - 1996 癌抑制遺伝子座のゲノム構造解析:ゲノムシークエンシングによる発癌機構の解明
- 1996 - 1996 Macrophage scavenger receptors and atherosclerosis
- 1995 - 1995 心血管系の発生分化におけるエンドヤリンの意義と関連遺伝子ヒエラルキーの解明
- 1995 - 1995 Scavenger receptor deficient mice and macrophage function
- 1994 - 1995 ESTABLISHMENT OF AN ANIMAL MODEL FOR CONGENITAL CRANIOFACIAL DISEASES BY GENE TARGETING AND DEVELOPMENT OF THEIR GENETIC DIAGNOSIS.
- 1994 - 1995 Structure and function of macrophage scavenger receptors
- 1994 - 1995 Structure and function of macrophage scavenger receptors
- 1994 - 1995 ESTABLISHMENT OF MICE DEFICTENT IN A VASOACTIVE PEPTIDE BY GENE TARGETING AND THEIR APPLICATION TO PATHOPHYSIOLOGICAL ANALYSIS
- 1993 - 1995 Generation of Animal Models for Diabetes by Transgenic and Gene Targeting Technology
- 1994 - 1994 心筋細胞の発生分化及び肥大におけるエンドセリンの意義-エンドセリン遺伝子標的欠損マウスを用いた検討
- 1993 - 1994 A Study on the Association between Polymorphism in Dopamine D_4 Receptor Gene and Psychiatric Diseases
- 1993 - 1994 Application of gene targeting to the study of atherosclerosis
- 1993 - 1993 インターロイキン-2受容体α鎖遺伝子の転写後の発現調節機構の解明
- 1993 - 1993 血管内皮、平滑筋細胞,マクロファージにおけるスカベンジャー受容体の発現
- 1992 - 1993 Mouse genetics of macrophage scavenger receptors and atherosclerosis
- 1991 - 1993 Cancer therapy by way of inhibition of farnesylation of ras proteins
- 1992 - 1992 発生工学的手法によるエンドセリン遺伝子欠損マウスの作製とその生理機能の解析
- 1991 - 1992 Molecular biology of macrophage scavenger receptors and modified LDL;
- 1990 - 1991 Regulation of Macrophage Scavenger Receptor and Atherosclerosis
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Papers (369)：
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Toshifumi Tatsumi, Songji Zhao, Akitomo Kasahara, Miho Aoki, Ken-ichi Nishijima, Naoyuki Ukon, Tatsuhiko Kodama, Kazuhiro Takahashi, Akira Sugiyama, Kohshin Washiyama, et al. In vivo-stable bis-iminobiotin for targeted radionuclide delivery with the mutant streptavidin. Bioorganic & Medicinal Chemistry Letters. 2024. 129803-129803
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Ryo Ito, Shiyu Xie, Myagmar Tumenjargal, Yuto Sugahara, Chaoran Yang, Hiroki Takahashi, Makoto Arai, Shin-Ichi Inoue, Aoi Uchida, Kenji Nakano, et al. Mitochondrial biogenesis in white adipose tissue mediated by JMJD1A-PGC-1 axis limits age-related metabolic disease. iScience. 2024. 27. 4. 109398-109398
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Jean-Charles Fruchar, Jamila Fruchart-Najib, Shizuya Yamashita, Peter Libby, Koutaro Yokote, Tatsuhiko Kodama, Yohei Tomita, Paul M. Ridker, Michel P. Herman, Alberto Zambo. Lessons from PROMINENT and prospects for pemafibrate. Cardiovascular Diabetology. 2024. in press
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Ryuichi Nakahara, Sho Aki, Maki Sugaya, Haruka Hirose, Miki Kato, Keisuke Maeda, Daichi M Sakamoto, Yasuhiro Kojima, Miyuki Nishida, Ritsuko Ando, et al. Hypoxia activates SREBP2 through Golgi disassembly in bone marrow-derived monocytes for enhanced tumor growth. The EMBO journal. 2023. e114032
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Juri Sakata, Toshifumi Tatsumi, Akira Sugiyama, Akihiro Shimizu, Yuya Inagaki, Hiroto Katoh, Takefumi Yamashita, Kazuki Takahashi, Sho Aki, Yudai Kaneko, et al. Antibody-mimetic drug conjugate with efficient internalization activity using anti-HER2 VHH and duocarmycin. Protein Expression and Purification. 2023. 106375-106375
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MISC (92)：
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川村猛, 中村有子, 近岡洋子, 中山綾, 福田暁子, 紅露拓, 辻嘉代子, WEI Feifei, 長岡孝治, 田中浩揮, et al. Neoantigen discovery by immunopeptidomics for mRNA cancer vaccines. 日本プロテオーム学会大会プログラム・抄録集. 2024. 2024 (Web)
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高橋和希, 巽俊文, 石井正純, 田中十志也, 児玉龍彦, 杉山暁, 杉山暁, 山次健三, 金井求. Functional-protein-Drug Conjugates with Photoresponsive Self-inactivation Mechanisms. 日本薬学会年会要旨集(Web). 2023. 143rd
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坂田樹里, 巽俊文, 山次健三, 児玉龍彦, 金井求, 徳山英利, 杉山暁. Antibody Mimetic Drug Conjugateによるがん治療法開発. 日本抗体学会学術大会プログラム・抄録集(Web). 2023. 2nd
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山次健三, 高橋和希, 加藤洋人, 山下雄史, 安藝翔, 巽俊文, 金子雄大, 川村猛, 三浦麻衣, 石井正純, et al. Antibody-Mimetic Drug Conjugate: AMDC comprised of modified streptavidin and bisiminobiotin, and its use in near-infrared phototherapy. メディシナルケミストリーシンポジウム講演要旨集. 2022. 39th (CD-ROM)
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高橋和希, 杉山暁, 巽俊文, 児玉龍彦, 山次健三, 金井求. Near-infrared photoimmunotherapy using symmetric silicon phthalocyanine. 日本薬学会年会要旨集(Web). 2020. 140th
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Education (3)：
- 1984 - 東京大学医学博士
- 1971 - 1977 The University of Tokyo Faculty of Medicine School of Medicine
- - 1971 東京教育大学付属駒場高等学校
Professional career (1)：
Work history (11)：
- 2018 - 現在 The University of Tokyo Research Center for Advanced Science and Technology
- 2004 - 2018 The University of Tokyo Research Center for Advanced Science and Technology
- 2011 - 2017 The University of Tokyo Radioisotope Center
- 2002 - 2004 The University of Tokyo Research Center for Advanced Science and Technology
- 1996 - 2002 The University of Tokyo Research Center for Advanced Science and Technology
- 1989 - 1996 The University of Tokyo Faculty of Medicine
- 1985 - 1989 Massachusetts Institute of Technology
- 1984 - 1985 The University of Tokyo Faculty of Medicine
- 1980 - 1984 The University of Tokyo Faculty of Medicine
- 1979 - 1980 都立駒込病院 感染症科 医師
- 1977 - 1979 The University of Tokyo Faculty of Medicine University Hospital
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Awards (2)：
- 1998 - ベーリンガーインゲルハイム社 ベルツ賞35周年記念賞
- 1997 - 読売新聞社テクノフォーラム ゴールド・メダル賞
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