Research field (4):
Molecular biology
, Chemical biology
, Pharmaceuticals - chemistry and drug development
, Biochemistry
Research keywords (4):
スクリーニング
, バイオイメージング
, 蛍光イメージング
, レドックス
Research theme for competitive and other funds (1):
2018 - 2022 Development of GSTP1 fluorescent probes for the elucidation of the function of GSTP1 in cancer cells.
Papers (25):
Kouichi Yanagi, Toru Komatsu, Yuuta Fujikawa, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Tasuku Ueno, Kenjiro Hanaoka, Yasuteru Urano. Development of pathway-oriented screening to identify compounds to control 2-methylglyoxal metabolism in tumor cells. Communications Chemistry. 2023. 6. 1
Yuuta Fujikawa, Kenta Terakado, Sayaka Nezu, Kota Noritsugu, Yuki Maemoto, Akihiro Ito, Hideshi Inoue. Improving reactivity of naphthalimide-based GST probe by imparting TPP cation: Development and application for live cell imaging. Bioorganic & medicinal chemistry letters. 2022. 80. 129109-129109
Yuuta Fujikawa, Masaya Mori, Minami Tsukada, Seiya Miyahara, Honoka Sato-Fukushima, Eita Watanabe, Yuko Murakami-Tonami, Hideshi Inoue. Pi-class Glutathione S-transferase (GSTP1)-selective fluorescent probes for multicolour imaging with various cancer-associated enzymes. Chembiochem : a European journal of chemical biology. 2022
Kodai Watanabe, Yuuta Fujikawa, Yuko Murakami-Tonami, Masaya Mori, Megumi Sakata, Hideshi Inoue. Design and synthesis of versatile GSTP1-specific fluorogenic substrates for the highly sensitive detection of GSTP1 activity in living cells. Talanta. 2022. 251. 123796-123796
Kazue Inaba, Kana Ebihara, Miki Senda, Ryunosuke Yoshino, Chisako Sakuma, Kotaro Koiwai, Daisuke Takaya, Chiduru Watanabe, Akira Watanabe, Yusuke Kawashima, et al. Molecular action of larvicidal flavonoids on ecdysteroidogenic glutathione S-transferase Noppera-bo in Aedes aegypti. BMC biology. 2022. 20. 1. 43-43
海老原佳奈, 稲葉和恵, 千田美紀, 安孫子ユミ, 佐久間知佐子, 小祝孝太郎, 高谷大輔, 渡邉千鶴, 今村理世, 岡部隆義, et al. Mode of action of new compounds against glutathione S-transferase Noppera-bo from Aedes aegypti. 日本農芸化学会大会講演要旨集(Web). 2023. 2023
2008/10 - Lipid Peroxidation2008 Young Investigator Award Design and synthesis of the fluorescence probes for Glutathione S-Transferase(GST) and application for activity imaging in live cells
THE JAPANESE CANCER ASSOCIATION
, SOCIETY FOR FREE RADICAL RESEARCH JAPAN
, JAPANESE SOCIETY FOR CHEMICAL BIOLOGY
, THE PHARMACEUTICAL SOCIETY OF JAPAN